In 2021, climate change fuelled heatwaves, cold spells, forest fires and flooding, causing suffering and avoidable deaths worldwide. The heat dome that developed over the US Pacific Northwest and western Canada at the end of June was so intense that the occurrence of such an event would be almost impossible in the absence of human-caused climate change 1 . The heatwave caused more than 1,000 excess deaths and a 69-fold increase in emergency department visits, compared with the same period in 2019. Critical infrastructure was affected and high intertidal temperatures combined with low tides resulted in the death of over a million shellfish, affecting livelihoods, food security and recreation 2 . In July, heavy rainfall caused severe flooding that resulted in at least 184 deaths in Germany and 38 in Belgium, as well as considerable infrastructure damage 3 . The likelihood of this extreme rainfall event was increased by climate change. Other extreme events in 2021 included wildfires in Algeria, California, Greece and Turkey; and flooding in Australia, Japan and China. No inhabited continent was unaffected. Similar to the COVID-19 pandemic, these extreme events affected all of society and highlighted particularly vulnerable populations and regions as well as the wide range of interconnections within and across communities.