Butane-2,3-dionethiosemicarbazone: An oxime with antioxidant properties

Puntel, Gustavo Orione; Carvalho, Nélson Rodrigues de; Gubert, Priscila; Palma, Aline Schwertner; Corte, Cristiane Lenz Dalla; Ávila, Daiana Silva; Pereira, Maria Estér; Carratu, Vanessa Santana; Bresolin, Leandro; Rocha, João Batista Teixeira da; Soares, Félix Alexandre Antunes

doi:10.1016/j.cbi.2008.09.028

Cited by 35 publications

(24 citation statements)

References 42 publications

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“…This effect can be seen on the results obtained using the oxime, which reduced the levels of TBARS at the control levels, having the important role in the reversion of lipid peroxidation and in the protection of integrity and functioning of tissues and cells. Accordingly, in previous studies, Puntel et al (2009) demonstrated that the 2,3-dione thiosemicarbazone oxime was effective in preventing the lipid peroxidation induced by different inductors in tissues of mice, in studies in vitro and ex vivo. These authors demonstrated an important scavenging activity of this oxime, at nanomolar concentrations, against hydroxyl (OH•), nitric oxide (NO) and 1,1-diphenyl-2-picrylhydrazyl (DPPH•) radicals.…”

Section: Discussionmentioning

confidence: 99%

“…at 5 mg/kg body weight (10 ml/kg, dissolved in saline) . Thirty minutes after the injection of CdCl 2 , mice received a single subcutaneous (s.c.) administration of the butane-2,3-dionethiosemicarbazone oxime at 10 mg/kg (10 ml/kg, dissolved in dimethyl sulfoxide 10%) (Puntel et al, 2009).…”

Section: Exposurementioning

confidence: 99%

“…Puntel et al (2009) suggested, in an in vitro study, antioxidant and possible chelating properties of a new oxime, the butane-2,3-dione thiosemicarbazone oxime (Fig. 1).…”

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Effects of butane-2,3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Section: Exposurementioning

confidence: 99%

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Effects of butane-2,3-dione thiosemicarbazone oxime on testicular damage induced by cadmium in mice

et al. 2012

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“…Antioxidants have been suggested as adjunct to OP antidotes (28, Tables 2 to 4). One oxime has been reported to possess antioxidant property (29), but among the impressive volume of published articles, only two survival studies documented the benefi ts of antioxidants. Most of the studies were done on moderately or highly toxic compounds.…”

Section: Oxidative Stress and Use Of Antioxidants In Op Poisoningmentioning

confidence: 99%

Antioxidants in Organophosphorus Compounds Poisoning

Nurulain

Szegi

Tekes

et al. 2013

Archives of Industrial Hygiene and Toxicology

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Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the role of antioxidants in reducing the mortality and morbidity induced by OP compounds has scarcely been verifi ed, as well as their role as adjunct treatment compounds for both structurally and functionally different OP compounds. The present review of the literature was undertaken to establish the role of antioxidants in survival studies following acute exposure to OP compounds. The review found no substantial evidence that antioxidants demonstrate any positive effect following extremely toxic poisoning. However, for a more comprehensive and rational conclusion, further research needs to be conducted. Nurulain SM et al. ANTIOXIDANTS AND ORGANOPHOSPHORUS POISONING Arh Hig Rada Toksikol 2013;64:169-177 KEY WORDS: acute poisoning, oxidative stress, survival study Intoxication by organophosphorus compoundsThe history of organophosphorus compounds (OP) and their poisonous effect stretches throughout more than a century. These compounds manifest their toxicity by irreversibly inhibiting the enzyme acetylcholinesterase at the nerve synapse. Despite decades-long research, mortality caused by acute OP poisoning continues to be high (1), while no new standard therapies are being introduced. There are over 150 different types of synthesized OPs, though their generalized structure is much the same. Each OP has a unique profile of toxicity and behaviour. For instance, death due to dichlorvos poisoning occurs very rapidly, while dimethoate toxicity takes several hours to develop (2), even though both belong to the same OP class. From the standpoint of chemistry, OP c o m p o u n d s c o m p r i s e o rg a n o p h o s p h a t e s , organophosphonates and organophosphinates, each of which is further divided into sub-groups. Other classifi cations of OPs are based on the lethality of a compound. According to the classifi cation of the World Health Organisation (WHO) (3), Class Ia belongs to extremely toxic OPs, Ib are highly toxic, Class II comprises moderately toxic, whereas Class III consists of mildly toxic OP compounds. Some examples are shown in Table 1. In addition, there are also the deadly organophosphorus chemical weapons (OPWs), called nerve agents.Acute organophosphate insecticide poisoning manifests itself through three different phases of toxicity; namely, acute cholinergic crisis, which occurs from within a few minutes to twenty-four hours;Brought to you by |

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“…These compounds have antimicrobial, antioxidant, antitumor, anti-depressive, antiviral agents, and anticonvulsant properties [2][3][4][5][6][7] . Some oximation methods have been reported 8 .…”

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confidence: 99%