Butein impairs the protumorigenic activity of malignant pleural mesothelioma cells

Cioce, Mario; Canino, Claudia; Pulito, Claudio; Muti, Paola; Strano, Sabrina; Blandino, Giovanni

doi:10.4161/cc.11.1.18474

Cited by 30 publications

(36 citation statements)

References 61 publications

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“…Butein has long been studied in various disease model systems including cancer [3-7,9,11,13,14,18,20-22,24]. Recent researches have revealed that butein inhibited breast cancer cell proliferation, migration and invasion in different types of breast cancer cells [8,13,14].…”

Section: Discussionmentioning

confidence: 99%

“…Butein inhibited skin carcinogenesis in female CD-1 mice by inhibiting epidermal 12-lipoxygenage activity, while not affecting PKC activation [2]. Butein also induced apoptotic cell death in colon adenocarcinoma cells [9], leukemic cells [6,10], lymphoma cells [11], multiple myeloma cells [12], breast cancer cells [13,14], osteosarcoma cells [15], hepatocellular carcinoma cells [16,17], prostate cancer cells [18,19], uveal melanoma cells [20], neuroblastoma cells [21], and malignant pleural mesothelioma cells [22]. In addition, butein inhibited cell migration and invasion in hepatocellular carcinoma cells [23], bladder cancer cells [24] and pancreatic and breast cancer cells [8].…”

Section: Introductionmentioning

confidence: 99%

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Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species

Cho

Woo

2014

J Exp Clin Cancer Res

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BackgroundButein has various functions in human diseases including cancer. While anti-cancer effects of butein have been revealed, it is urgent to understand a unique role of butein against cancer. In this study, we demonstrate that butein inhibition of reactive oxygen species (ROS) production results in suppression of breast cancer growth.MethodsDifferent breast cancer cell lines were treated with butein and then subjected to cell viability and apoptosis assays. Butein-sensitive or -resistant breast cancer cells were injected into mammary fat pads of immunocompromised mice and then butein was injected. Breast cancer cells were categorized on the basis of butein sensitivity.ResultsButein reduced viabilities of different breast cancer cells, while not affecting those of HER2-positive (HER2+) HCC-1419, SKBR-3 and HCC-2218 breast cancer cells. Butein reduction of ROS levels was correlated with apoptotic cell death. Furthermore, butein reduction of ROS level led to inhibitions of AKT phosphorylation. N-acetyl-L-cysteine (NAC), a free radical scavenger, also reduced ROS production and AKT phosphorylation, resulting in apoptotic cell death. In contrast, inhibitory effects of both butein and NAC on ROS production and AKT phosphorylation were not detected in butein-resistant HER2+ HCC-1419, SKBR-3 and HCC-2218 cells. In the in vivo tumor growth assays, butein inhibited tumor growth of butein-sensitive HER2+ BT-474 cells, while not affecting that of butein-resistant HER2+ HCC-1419 cells. Moreover, butein inhibition of ROS production and AKT phosphorylation was confirmed by in vivo tumor growth assays.ConclusionsOur study first reveals that butein causes breast cancer cell death by the reduction of ROS production. Therefore, our finding provides better knowledge for butein effect on breast cancer and also suggests its treatment option.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Butein suppresses breast cancer growth by reducing a production of intracellular reactive oxygen species

Cho

Woo

2014

J Exp Clin Cancer Res

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“…Butein is promising natural chalcone flavonoid. It has been shown that butein displays anticancer abilities against varying human cancer cells [3][4][5][6][7][8]. In this study, the anticancer activities of butein were demonstrated in colorectal cancer model in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 91%

“…Butein (3,4,2 0 ,4 0 -tetrahydroxychalcon) is a chalcone flavonoid. Butein has been shown to display anticancer activities against various human cancer cells, including colorectal carcinoma [3], leukemia [4], melanoma [5], breast carcinoma [6], hepatoma [7], and malignant pleural mesothelioma [8]. In addition to anticancer ability, butein is an anti-adipogenic compound [9].…”

Section: Introductionmentioning

confidence: 99%