BVDV Npro protein mediates the BVDV induced immunosuppression through interaction with cellular S100A9 protein

Darweesh, Mahmoud; Rajput, Mrigendra; Braun, L. J.; Rohila, Jai S.; Chase, Christopher

doi:10.1016/j.micpath.2018.05.047

Cited by 23 publications

(23 citation statements)

References 64 publications

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“…Another study indicated that PMNC infected with Ncp or Cp released unknown factor(s) in the culture media that could be of cellular or viral origin [52,55]. Previously, secreted Erns viral glycoprotein played an important role in lymphocyte apoptosis induced by BVDV and CSFV [19].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Bovine Viral Diarrhea Virus (BVDV) Strains and the Corresponding Infected-Macrophages’ Supernatant on Macrophage Inflammatory Function and Lymphocyte Apoptosis

Abdelsalam

Rajput

Elmowalid

et al. 2020

Viruses

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Bovine viral diarrhea virus (BVDV) is an important viral disease of cattle that causes immune dysfunction. Macrophages are the key cells for the initiation of the innate immunity and play an important role in viral pathogenesis. In this in vitro study, we studied the effect of the supernatant of BVDV-infected macrophage on immune dysfunction. We infected bovine monocyte-derived macrophages (MDM) with high or low virulence strains of BVDV. The supernatant recovered from BVDV-infected MDM was used to examine the functional activity and surface marker expression of normal macrophages as well as lymphocyte apoptosis. Supernatants from the highly virulent 1373-infected MDM reduced phagocytosis, bactericidal activity and downregulated MHC II and CD14 expression of macrophages. Supernatants from 1373-infected MDM induced apoptosis in MDBK cells, lymphocytes or BL-3 cells. By protein electrophoresis, several protein bands were unique for high-virulence, 1373-infected MDM supernatant. There was no significant difference in the apoptosis-related cytokine mRNA (IL-1beta, IL-6 and TNF-a) of infected MDM. These data suggest that BVDV has an indirect negative effect on macrophage functions that is strain-specific. Further studies are required to determine the identity and mechanism of action of these virulence factors present in the supernatant of the infected macrophages.

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Section: Discussionmentioning

confidence: 99%

The Effect of Bovine Viral Diarrhea Virus (BVDV) Strains and the Corresponding Infected-Macrophages’ Supernatant on Macrophage Inflammatory Function and Lymphocyte Apoptosis

Abdelsalam

Rajput

Elmowalid

et al. 2020

Viruses

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“…The pestivirus, bovine viral disease virus (BVDV), produces respiratory and gastrointestinal diseases in cattle worldwide [ 15 , 16 ], and is a well-known immunodepressive agent that frequently facilitates the occurrence of concomitant secondary infections in susceptible animals [ 16 , 17 ]. Ovine gammaherpesvirus-2 (OvHV-2) is the cause of sheep associated-malignant catarrhal fever (SA-MCF), a severe, lymphotropic, frequently fatal disease of cattle [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf

Headley

Müller

Oliveira

et al. 2020

Microbial Pathogenesis

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Diphtheric aspergillosis tracheitis is an uncommon syndrome described in human pathology, usually associated with immunosuppression in the affected individuals. Interestingly, no comparative/equivalent cases were found in domestic animals. This report describes the pathological and mycological findings associated with diphtheric aspergillosis tracheitis in an immunocompromised calf. The main pathological findings were diphtheric tracheitis and rhinitis, and necrotizing ruminitis associated with intralesional septate, acute branching fungal hyphae consistent with Aspergillus spp. Mycological culture and isolation confirmed the fungal hyphae as A. fumigatus due to characteristic features. Immunohistochemistry (IHC) assays identified intralesional antigens of bovine viral diarrhea virus (BVDV) and malignant catarrhal fever virus (MCFV) at the trachea and small intestine; IHC detected intralesional antigens of bovine alphaherpesvirus 1 (BoHV-1) only at the trachea. These findings confirmed the simultaneous occurrence of A. fumigatus with concomitant infections due to BVDV, MCFV, and BoHV-1 in this calf. Since ovine gammaherpesvirus-2 (OvHV-2) is the cause of MCF in Brail, it is likely that the intralesional MCFV antigens identified were those of OvHV-2. In this case, disseminated aspergillosis was probably associated with the undeveloped immunological status of the calf that was further impaired due to the combined immunodepressive effects of BVDV and BoHV-1 infections. Although BVDV and BoHV-1 are infectious disease pathogens frequently associated with the development of bovine respiratory disease (BRD) in feedlot and dairy cattle, the identification of intralesional OvHV-2-like antigens in several parts of the lungs suggest that this MCFV also played a role in the BRD-associated lesions identified in this calf.

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“…2b). The BVDV can induce immunosuppression, so BVDV infecting animals easily facilitate secondary infections by other pathogens Alkheraif et al 2017;Darweesh et al 2018). Virus isolation in this study was performed because it is commonly considered to be the gold standard for diagnosis of BVDV (Lanyon et al 2014a, b), and eight NCP and BVDV-1 strains as well as one CP and BVDV-2 strain were successfully isolated.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

Hou

Zhao

Wang

et al. 2018

Trop Anim Health Prod

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Bovine viral diarrhea virus (BVDV) is a worldwide spreading pestivirus affecting cattle and other ruminants; however, there have been few reports on epidemiologic investigation of BVDV in eastern China. In this study, bulk tank milk from 36 herds of dairy cattle in eastern China was submitted to serological investigations, 77.8% of herds was BVDV antibody positive. Individual animal status in two herds was further investigated collecting blood samples, the positive ratio was 49.74% and 24.64%, and the average positive ratio of calves, heifers, and lactating cows was 15.94%, 40.16%, and 41.7%, respectively. Moreover, clinical survey was carried out among 8170 dairy cattle from 36 herds, for diarrhea syndrome, respiratory problems and reproductive failure, and pathogens of all clinical cattle were further investigated. The results showed that BVDV was one of the main pathogen, which infected animals combining with various other viruses. Then, nine BVDV strains were isolated; phylogenetic analysis showed that BVDV subtypes currently circulating in eastern China were BVDV 1a and BVDV 1c. In addition, out of 377 cows tested, the 1.86% detected positive to the BVDV antigen. This study provided the foundation of further study on vaccination and control strategies of BVDV in eastern China.

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BVDV Npro protein mediates the BVDV induced immunosuppression through interaction with cellular S100A9 protein

Cited by 23 publications

References 64 publications

The Effect of Bovine Viral Diarrhea Virus (BVDV) Strains and the Corresponding Infected-Macrophages’ Supernatant on Macrophage Inflammatory Function and Lymphocyte Apoptosis

The Effect of Bovine Viral Diarrhea Virus (BVDV) Strains and the Corresponding Infected-Macrophages’ Supernatant on Macrophage Inflammatory Function and Lymphocyte Apoptosis

Diphtheric aspergillosis tracheitis with gastrointestinal dissemination secondary to viral infections in a dairy calf

Prevalence of bovine viral diarrhea virus in dairy cattle herds in eastern China

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