Bypass of the duodenum improves insulin resistance much more rapidly than sleeve gastrectomy

Garrido‐Sánchez, Lourdes; Murri, Mora; Rivas-Becerra, Jose; Ocaña-Wilhelmi, Luis; Cohen, Ricardo; Garcı́a-Fuentes, Eduardo; Tinahones, Francisco J.

doi:10.1016/j.soard.2011.03.010

Cited by 56 publications

(40 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31 Furthermore, reduction of diabetes has been found to occur more frequently among patients who underwent gastric bypass surgery that excluded the duodenum from the nutrient pathway and changed the bowel metabolism, thus reducing insulin resistance faster. 32 Therefore, the significant decrease in antidiabetic drug use observed in our study might be related to the surgical technique used on most subjects (91%).…”

Section: Antidiabetic Drugsmentioning

confidence: 68%

Medication and nutritional supplement use before and after bariatric surgery

Backes

Lopes²,

Tetelbom

et al. 2016

Sao Paulo Med. J.

View full text Add to dashboard Cite

CONTEXT AND OBJECTIVE: Bariatric surgery has been an effective alternative treatment for morbid obesity and has resulted in decreased mortality, better control over comorbidities and reduced use of drugs. The objective of this study was to analyze the impact of bariatric surgery on medication drug and nutritional supplement use. DESIGN AND SETTING: Longitudinal study of before-and-after type, on 69 morbidly obese patients in a public hospital in Porto Alegre. METHODS: Through interviews, the presence of comorbidities and use of drugs with and without prescription were evaluated. RESULTS: Among the 69 patients interviewed, 85.5% had comorbidities in the preoperative period, with an average of 2.3 (± 1.5) per patient. The main comorbidities reported were hypertension, diabetes and dyslipidemia. 84.1% of the patients were using prescribed drugs in the preoperative period. The mean drug use per patient was 4.8, which decreased to 4.4 after the procedure. The surgery enabled significant reduction in use of most antidiabetic (84%), antilipemic (77%) and antihypertensive drugs (49.5%). On the other hand, there was a significant increase in use of multivitamins and drugs for disorders of the gastrointestinal tract. The dosages of most of the drugs that continued to be prescribed after surgery were decreased, but not significantly. CONCLUSION: After bariatric surgery, there were increases in the use of vitamins, gastric antisecretory drugs and antianemic drugs. Nevertheless, there was an overall reduction in drug use during this period, caused by suspension of drugs or dose reduction. RESUMO CONTEXTO E OBJETIVO:A cirurgia bariátrica tem sido uma alternativa efetiva de tratamento para a obesidade mórbida, resultando na diminuição da mortalidade, melhor controle das comorbidades e redução no uso de medicamentos. O objetivo deste estudo foi analisar o impacto da cirurgia bariátrica sobre a utilização de medicamentos e suplementos nutricionais. TIPO DE ESTUDO E LOCAL: Estudo longitudinal do tipo antes e depois com 69 pacientes obesos mórbi-dos em um hospital público de Porto Alegre. MÉTODOS: Nas entrevistas, foram avaliados a presença de comorbidades e o uso de medicamentos com e sem prescrição médica. RESULTADOS: De 69 pacientes entrevistados, 85,5% apresentaram comorbidades no período pré-cirúrgi-co, média de 2,3 (± 1,5) por paciente. As principais comorbidades relatadas foram hipertensão, diabetes e dislipidemias. 84,1% dos pacientes estavam em uso de medicamentos sob prescrição médica, no período pré-cirúrgico. A média de uso de medicamentos por paciente foi de 4,8, reduzindo para 4,4 após o procedimento. A cirurgia proporcionou diminuição significativa do uso da maioria dos antidiabéticos (84%), antilipêmicos (77%) e anti-hipertensivos (49,5%). Por outro lado, observou-se aumento significativo na utilização de multivitamínicos e medicamentos para desordens do trato gastrointestinal. A maior parte dos medicamentos que continuaram sendo prescritos após a cirurgia teve sua dose reduzida, no entanto, esta redução nã...

show abstract

Section: Antidiabetic Drugsmentioning

confidence: 68%

Medication and nutritional supplement use before and after bariatric surgery

Backes

Lopes²,

Tetelbom

et al. 2016

Sao Paulo Med. J.

View full text Add to dashboard Cite

show abstract

“…Apart from a reduction in nutrient absorption, BS improves or resolves many obesity-related co-morbidities [12][13][14]. Interestingly, the improvement in carbohydrate metabolism occurs even before significant weight loss could intervene.…”

mentioning

confidence: 99%

“…Interestingly, the improvement in carbohydrate metabolism occurs even before significant weight loss could intervene. Thus, other mechanisms must be participating, apart from weight reduction, which explain early metabolic improvement after surgery [13][14][15][16][17]. There are several different bariatric procedures such as Roux-en-Y gastric bypass (RYGB), biliopancreatic diversion (BPD), sleeve gastrectomy (SG), and adjustable gastric banding.…”

mentioning

confidence: 99%

Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery

Clemente‐Postigo

Roca-Rodríguez

Camargo

et al. 2015

Surgery for Obesity and Related Diseases

View full text Add to dashboard Cite

“…In a study with diabetic obese patients who underwent sleeve gastrectomy or BPD, Garrido-Sanchez et al [6] observed immediate postoperative insulin resistance changes in patients in whom the duodenum was bypassed. In patients with sleeve gastrectomy, similar changes were observed only 1 month after surgery [6].…”

Section: Discussionmentioning

confidence: 99%