BysR, a LysR-type Pleiotropic Regulator, Controls Production of Occidiofungin by Activating the LuxR-type transcriptional regulator AmbR1 in Burkholderia sp. JP2-270
Abstract:Occidiofungin is a highly effective antifungal glycopeptide produced by certain Burkholderia strains. The ocf gene cluster directing occidiofungin biosynthesis is regulated by cluster-specific regulators encoded by ambR homolog(s) within the same gene cluster, while it remains unknown to what extent occidiofungin biosynthesis is connected with the core regulation network. Here, we report that a LysR-type regulator BysR acts as a pleotropical regulator, and is essential for occidiofungin biosynthesis by directl… Show more
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