Bystander effects induced by the interaction between urothelial cancer cells and irradiated adipose tissue-derived stromal cells in urothelial carcinoma

Kawasaki, Mikiko; Nagase, Kei; Aoki, Shigehisa; Udo, Kazuma; Tobu, Shohei; Rikitake-Yamamoto, Mihoko; Kubota, Masaya; Narita, Takayuki; Noguchi, Mitsuru

doi:10.1007/s13577-022-00668-7

Cited by 1 publication

(1 citation statement)

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“…For more than two decades, accumulating evidence has shown that these effects are the results of a dynamic and integrated process that is initiated by irradiated cells and transmitted to the neighboring cells [ 5 ]. In vitro and in vivo studies on RIBE have been carried out with high and low LET radiation [ 6 , 7 , 8 ], normal and tumor cells [ 9 , 10 ], and regular two-dimensional (2D) monolayer cell systems and three-dimensional (3D) tissue systems [ 11 ]. Changes observed in the bystander cells included reduced clonogenic survival, increased sister-chromatid exchange, micronuclei formation, apoptosis, and alteration of gene expression and RNA-transcript level.…”

Section: Non-target Effectsmentioning

confidence: 99%

Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams

Zhang

2022

Biology

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Although direct damage to nuclear DNA is considered as the major contributing event that leads to radiation-induced effects, accumulating evidence in the past two decades has shown that non-target events, in which cells are not directly irradiated but receive signals from the irradiated cells, or cells irradiated at extranuclear targets, may also contribute to the biological consequences of exposure to ionizing radiation. With a beam diameter at the micrometer or sub-micrometer level, microbeams can precisely deliver radiation, without damaging the surrounding area, or deposit the radiation energy at specific sub-cellular locations within a cell. Such unique features cannot be achieved by other kinds of radiation settings, hence making a microbeam irradiator useful in studies of a radiation-induced bystander effect (RIBE) and cytoplasmic irradiation. Here, studies on RIBE and different responses to cytoplasmic irradiation using microbeams are summarized. Possible mechanisms related to the bystander effect, which include gap-junction intercellular communications and soluble signal molecules as well as factors involved in cytoplasmic irradiation-induced events, are also discussed.

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Section: Non-target Effectsmentioning

confidence: 99%

Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams

Zhang

2022

Biology

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show abstract

Bystander effects induced by the interaction between urothelial cancer cells and irradiated adipose tissue-derived stromal cells in urothelial carcinoma

Cited by 1 publication

References 39 publications

Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams

Radiation-Induced Bystander Effect and Cytoplasmic Irradiation Studies with Microbeams

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