C 05 T cell epitope mapping ot the 65KD heat shock protein peptides in Behçet's disease and induction of eye lesions with the peptides in rats

Lehner, Tom; Pervin, K.; Childerstone, A.; Hasan, Adam; Direskineli, H.; Kasp, E; Whiston, Roy; Stanford,; Dumonde, D. C.; Shinnick, Thomas M.; Zee, Ruurd van der; Mizushima, Yutaka

doi:10.1016/s0248-8663(05)82252-0

Cited by 2 publications

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“…Four peptides derived from the Heat shock protein 65 (HSP65) sequence have been identified by T cell epitopes mapping, which stimulate specifically gd T cells from BD patients. These peptides showed significant homology with corresponding peptides derived from human HSP and may induce uveitis development (14)(15)(16). HSP65 and herpes simplex virus (HSV)-1, Streptococcus sanguis might have a common denominator, while cross-reaction leads to immunoreaction in individuals with hereditary susceptibility (16).…”

Section: Discussionmentioning

confidence: 99%

Case report and analysis: Behçet’s disease with lower extremity vein thrombosis and pseudoaneurysm

Wang

Zhang

et al. 2022

Front. Immunol.

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BackgroundBehçet’s disease (BD) is a unique autoimmune chronic systemic vasculitis that affects veins and arteries of all sizes. BD can lead to recurrent vascular events, especially venous thrombosis, with an incidence rate of 40%, or pseudoaneurysms formed under long-term inflammatory reaction or iatrogenic stimulation. BD-related risk factors promote endothelial dysfunction, platelet activation and overactivation of tissue factors leading to mural inflammatory thrombi. Thrombosis may be the first clinical manifestation of BD.Case presentationA 32-year-old man complaining of progressive swelling and pain in the right lower extremity for 30 days was initially diagnosed with “venous thrombosis of the right lower extremity,” using color Doppler ultrasonography. Patient underwent inferior vena cava filter placement combined with deep vein angioplasty of the right lower extremity and catheter-directed urokinase thrombolysis. Postoperative oral anticoagulant therapy was administered. However, the patient was readmitted 20 days later for pulsatile pain in the right groin. Prior medical history included 4 years of repeated oral and perineal ulcers, and 2 months of blurred vision. Abdominal computed tomography angiography (CTA) revealed rupture of the right common iliac artery (CIA) and left internal iliac artery (IIA), complicated by a pseudoaneurysm. Based on the clinical manifestations and other auxiliary examination results, the patient was re-diagnosed with “BD combined with deep venous thrombosis of the right lower extremity and an iliac artery pseudoaneurysm.” Stent implantation was performed for iliac artery pseudoaneurysm after symptoms were controlled with timely immunosuppressive therapy. After endovascular treatment, the patient underwent continued immunosuppressive therapy and dynamic reexaminations of abdominal CTA, which revealed that a small amount of contrast agent at the stent in the right CIA continued to flow into the cavity of the pseudoaneurysm; in addition, the size of the pseudoaneurysm was gradually increasing. Therefore, the patient underwent a second stent implantation for iliac artery pseudoaneurysm, and the condition improved further.ConclusionThe importance of early diagnosis of BD should be recognized, and the choice of interventional and surgical procedures should be carefully evaluated, as this may trigger further damage to vascular access in BD patients with aneurysm.

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Section: Discussionmentioning

confidence: 99%

Case report and analysis: Behçet’s disease with lower extremity vein thrombosis and pseudoaneurysm

Wang

Zhang

et al. 2022

Front. Immunol.

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“…Lehner et al [19] reported that uveitis could be induced in Lewis rats by 4 peptides derived from the sequence of the mycobacterial 65 kD hsp, which stimulate specifically TCR γδ lymphocyte from patients with BD and human 65 kD hsp derived peptides. Lehner groups' Lewis rats showed only single eye symptom.…”

Section: Animal Models Aiming To Elucidate the Immunopathogenesis mentioning

confidence: 99%

“…Heat shock protein (hsp) has also been implicated in the pathogenesis of several human and experimentally induced autoimmune diseases such as BD, both as target antigens and as intracellular chaperones involved in peptide binding to HLA antigens [ 18 ] ( Figure 1 ). Lehner et al [ 19 ] reported that uveitis could be induced in Lewis rats by 4 peptides derived from the sequence of the mycobacterial 65 kD hsp, which stimulate specifically TCR γδ lymphocyte from patients with BD and human 65 kD hsp derived peptides. Lehner groups' Lewis rats showed only single eye symptom.…”

Section: Animal Models Aiming To Elucidate the Immunopathogenesis mentioning

confidence: 99%

Animal Models in Behçet's Disease

Yıldırım

2012

Pathology Research International

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Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis, characterized by circulating immune complexes and complement activation, has gained increasing acceptance. To test and understand immunopathogenesis of Behçet's disease, animal models were developed based on enviromental pollutants, bacterial and human heat shock protein derived peptides, and virus injections. Using these animal models separately and/or concurrently allows for a more effective investigation into Behçet's disease. Animal models developed in the last 10 years aim at the development of efficient and safe treatment options.

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C 05 T cell epitope mapping ot the 65KD heat shock protein peptides in Behçet's disease and induction of eye lesions with the peptides in rats

Cited by 2 publications

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Case report and analysis: Behçet’s disease with lower extremity vein thrombosis and pseudoaneurysm

Case report and analysis: Behçet’s disease with lower extremity vein thrombosis and pseudoaneurysm

Animal Models in Behçet's Disease

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