C 60 -fullerenes for delivery of docetaxel to breast cancer cells: A promising approach for enhanced efficacy and better pharmacokinetic profile

Raza, Kaisar; Thotakura, Nagarani; Kumar, Pramod; Joshi, Mayank; Bhushan, Shashi; Bhatia, Amit; Kumar, Vipin; Malik, Ruchi; Sharma, Gajanand; Guru, Santosh Kumar; Katare, Om Prakash

doi:10.1016/j.ijpharm.2015.09.016

Cited by 121 publications

(65 citation statements)

References 39 publications

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“…Active tumor targeting has been realized through conjugation or decoration of specific ligands for drug-loaded particles. [34][35][36][37][38] However, such approaches are limited by many …”

Section: Discussionmentioning

confidence: 99%

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Zhang¹,

Wu²,

Zhang³

et al. 2017

IJN

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Purpose Polymeric micelles are attractive nanocarriers for tumor-targeted delivery of paclitaxel (PTX). High antitumor efficacy and low toxicity require that PTX mainly accumulated in tumors with little drug exposure to normal tissues. However, many PTX-loaded micelle formulations suffer from low stability, fast drug release, and lack of tumor-targeting capability in the circulation. To overcome these challenges, we developed a micellar formulation that consists of sodium cholate (NaC) and monomethoxy poly (ethylene glycol)- block -poly ( d , l -lactide) (mPEG-PDLLA). Methods PTX-loaded NaC-mPEG-PDLLA micelles (PTX-CMs) and PTX-loaded mPEG-PDLLA micelles (PTX-Ms) were formulated, and their characteristics, particle size, surface morphology, release behavior in vitro, pharmacokinetics and in vivo biodistributions were researched. In vitro and in vivo tumor inhibition effects were systematically investigated. Furthermore, the hemolysis and acute toxicity of PTX-CMs were also evaluated. Results The size of PTX-CMs was 53.61±0.75 nm and the ζ-potential was −19.73±0.68 mV. PTX was released much slower from PTX-CMs than PTX-Ms in vitro. Compared with PTX-Ms, the cellular uptake of PTX-CMs was significantly reduced in macrophages and significantly increased in human cancer cells, and therefore, PTX-CMs showed strong growth inhibitory effects on human cancer cells. In vivo, the plasma AUC 0−t of PTX-CMs was 1.8-fold higher than that of PTX-Ms, and 5.2-fold higher than that of Taxol. The biodistribution study indicated that more PTX-CMs were accumulated in tumor than PTX-Ms and Taxol. Furthermore, the significant antitumor efficacy of PTX-CMs was observed in mice bearing BEL-7402 hepatocellular carcinoma and A549 lung carcinoma. Results from drug safety assessment studies including acute toxicity and hemolysis test revealed that the PTX-CMs were safe for in vivo applications. Conclusion These results strongly revealed that NaC-mPEG-PDLLA micelles can tumor-target delivery of PTX and enhance drug penetration in tumor, suggesting that NaC-mPEG-PDLLA micelles are promising nanocarrier systems for anticancer drugs delivery.

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Section: Discussionmentioning

confidence: 99%

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Zhang¹,

Wu²,

Zhang³

et al. 2017

IJN

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“…This would allow for reducing the drugs dosage, their concentrations on sites that are not of interest, and the side effects associated with chemotherapy and hormonal therapy [15,16]. In this regard, carbon nanomaterials with potential uses for the administration of drugs against cancer and breast cancer are being analyzed [17,22,23,[29][30][31]; they are considered as advantageous systems to control drug release in the organism and increase the efficiency of treatments and reduce their toxicity [17,32,33]. However, carbon nanomaterials have some disadvantages including their lack of solubility and low reproduction rate through their chemical functionalization and structural characterization.…”

Section: Drug Releasementioning

confidence: 99%

“…Recent studies in nanomedicine concluded that fullerenes, CNTs, and graphene have favorable properties for the carriage, targeted, and controlled delivery of chemotherapeutical drugs including taxol (paclitaxel), docetaxel (DTX), doxorubicin (DOX), and others [22,29,31,32,44,[50][51][52][53]. Raza et al [22] reported that the system conformed by the fullerene C 60 and DTX (C 60 /DXT) is able to improve up to 4.2 times the bioavailability of DTX and decreases the clearance of DTX by 50%.…”

Section: Drug Releasementioning

confidence: 99%

“…Raza et al [22] reported that the system conformed by the fullerene C 60 and DTX (C 60 /DXT) is able to improve up to 4.2 times the bioavailability of DTX and decreases the clearance of DTX by 50%. In addition, C 60 /DXT system showed an effective controlled release of ∼84.32% of DTX during a period of 120 hours, as well as compatibility with erythrocytes.…”

Section: Drug Releasementioning

confidence: 99%

“…Many properties of carbon nanomaterials, such as size, shape, surface structure and charge, chemical composition, aggregation and/or agglomeration, and solubility, can greatly influence their interactions with biomolecules and cells. For example, carbon nanomaterials have been employed to produce exceptional images of tumor sites [20,21], impressive potential as high-efficiency delivery transporters for drugs and/or biomolecules into cells [20,22,23]. Therefore, the main emphasis of this article focuses on the discussion of carbon nanomaterials and their current applications in the identification, diagnosis, and treatment of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

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Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non‐small cell lung cancer patients

et al. 2019

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Background: Topoisomerase 2-alpha (TOP2A) is an enzyme that controls topologic changes in DNA during transcription and replication. ERCC1 is an enzyme that takes part in DNA repair processes. The purpose of this study was to assess the predictive role of particular single nucleotide polymorphisms (SNPs) in the promoter regions of TOP2A and ERCC1 genes in non-small cell lung cancer patients (NSCLC) treated with chemotherapy. Materials and methods: We enrolled 113 NSCLC patients treated in the first line with platinum-based chemotherapy. Effectiveness was available for 71 patients.

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C 60 -fullerenes for delivery of docetaxel to breast cancer cells: A promising approach for enhanced efficacy and better pharmacokinetic profile

Cited by 121 publications

References 39 publications

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel

Carbon Nanomaterials for Breast Cancer Treatment

Promoter polymorphisms of TOP2A and ERCC1 genes as predictive factors for chemotherapy in non‐small cell lung cancer patients

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