C/EBPα is indispensable for PML/RARα-mediated suppression of long non-coding RNA NEAT1 in acute promyelocytic leukemia cells

Tang, Doudou; Hu, Piao; Zhu, Dengqin; Luo, Yujiao; Chen, Mingjie; Zhang, Guangsen; Wang, Yewei

doi:10.18632/aging.203000

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…lncRNA NEAT1 is also involved in APL cell differentiation induced by ATRA. C/EBPα binds and transactivates NEAT1 whereas PML/RARα suppresses this process suggesting that PML/RARα could contribute to the pathogenesis of APL by suppressing C/EBPα targets (150).…”

Section: Crosstalk Between Other Nrs and Lncrnas In Cancermentioning

confidence: 99%

Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review)

Cantile,

Cerrone,

Di Bonito

et al. 2023

Int J Oncol

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Nuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR-mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR in a given cancer subtype is only one component of a larger transcriptional machinery that is controlled by multiple associated NRs and transcription factors. Additionally, their ability to regulate and to be regulated by molecules of non-coding RNAs, microRNAs as well as long non-coding RNAs, is opening new scenarios for understanding the role of NRs in cancer initiation and progression. In the present review, the authors aimed to outline the reciprocal interactions that exist between the main NRs and long non-coding RNAs in different tumor diseases, to suggest new diagnostic biomarkers as well as therapeutic strategies for these tumors.

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Section: Crosstalk Between Other Nrs and Lncrnas In Cancermentioning

confidence: 99%