c-kit Immunocytochemical Staining in the Cytologic Diagnosis of Metastatic Gastrointestinal Stromal Tumor

Cheuk, Wah; Lee, King-Chung; Chan, John K. C.

doi:10.1159/000328547

Cited by 26 publications

(22 citation statements)

References 11 publications

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“…Li et al (17) also found that mitoses in the resected malignant GISTs were seldom seen in FNAC smear. Besides, in the present and previous (14,15,19) studies malignant GISTs had no significant pleomorphism in the cytologic smears. The assessment of malignant potential is difficult based on cytomorphologic features alone and predictions about potential aggressiveness should be best reserved for gross and histologic examination of the resected specimen.…”

Section: Discussionsupporting

confidence: 61%

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Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Kwon¹,

Koh²,

Lee³

et al. 2002

J Korean Med Sci

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Recently the origin of gastrointestinal stromal tumors (GISTs) is thought be the interstitial cells of Cajal or primitive stem cells. This study was performed to evaluate the roles of fine needle aspiration cytology (FNAC), cell block preparation, and immunohistochemistry in the diagnosis of GISTs. Nine cases of GIST in which FNAC was performed were included in this study. Cytologically, the tumor cells characteristically occurred in closely packed cohesive tissue fragments with high cellular density often in bloody background. The tumor cells often formed fascicles with parallel, side-by-side arrangements of the nuclei. Histologically, GISTs were highly cellular spindle or epithelioid tumor with basophilic appearance. Immunohistochemically, GISTs were c-kit positive in all of nine cases, CD34 positive in seven, focally SMA positive in two, and S-100 and GFAP negative in all. Both histologic and cell block sections showed the same histologic and immunohistochemical features. Cytomorphologically GISTs show a broad morphologic spectrum but rarely a significant nuclear pleomorphism and the assessment of malignant potential is difficult based on cytology alone. However, in the appropriate clinical and radiologic setting, a confident diagnosis of primary or metastatic GIST can be established by FNAC, cell block, and immunohistochemistry.

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Section: Discussionsupporting

confidence: 61%

“…Although there have been only a few case reports and series of cases published (14)(15)(16)(17)(18)(19), every diagnosis was not supported by c-kit immunostain (18,19), cytohistologic correlation (16), and histologic diagnoses (16,18). Most of the cases were not correlated with follow-up data (14,17,18).…”

Section: Introductionmentioning

confidence: 99%

Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Kwon¹,

Koh²,

Lee³

et al. 2002

J Korean Med Sci

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“…18,19 Conversely, to our knowledge, none of the prior cytologic studies of LMS excluded the diagnosis of GIST by demonstrating c-kit negativity, a nearly universal finding in LMS. 26,27 A few exceptional c-kit-positive LMS cases were encountered in the current study, all of which demonstrated at most focal staining.…”

Section: Figure 2 (Continued)mentioning

confidence: 81%

“…4,14 Despite these difficulties, it is clinically important to make the distinction, 4 both because of differences in metastatic pattern and prognosis 15 and because of the recent development of tyrosine kinase inhibitors, which have the potential to target the specific molecular defect in GIST. 3,16,17 Because this differential diagnosis is challenging and important, and because of what we believe to be the paucity of prior reports, 18,19 we describe herein our experience with the cytologic diagnosis of GIST.…”

Section: Results Cytologic Samples Of Gists Typically Showed Irregulmentioning

confidence: 98%

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Cytologic diagnosis of gastrointestinal stromal tumor with emphasis on the differential diagnosis with leiomyosarcoma

Wieczorek

Faquin

Rubin

et al. 2001

Cancer

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Beacon of light! A new type of probe called an allosteric molecular beacon (aMB) has been designed for highly sensitive detection of nucleic acids, proteins, and small molecules. The aMB is designed in such way that target binding will activate its binding affinity to streptavidin microbeads for probe signal enrichment, noise reduction, and signal readout, which enables ultrasensitive target detection in complex biological samples (see scheme).

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2011

Soft Tissue Tumors

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c-kit Immunocytochemical Staining in the Cytologic Diagnosis of Metastatic Gastrointestinal Stromal Tumor

Cited by 26 publications

References 11 publications

Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Fine Needle Aspiration Cytology (FNAC) of Gastrointestinal Stromal Tumor: An Emphasis on Diagnostic Role of FNAC, Cell Block, and Immunohistochemistry

Cytologic diagnosis of gastrointestinal stromal tumor with emphasis on the differential diagnosis with leiomyosarcoma

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