c-MYB and c-MYC activation during the colon adenoma-adenocarcinoma sequence: Relationship with spontaneous apoptosis

Greco, C.; Alvino, S; Lapenta, R.; Grassi, Antonio; Stigliano, V.; Assissi, D.; Buglioni, Simonetta; Mottolese, Marcella; Casale, V.

doi:10.1016/s1590-8658(00)80699-4

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2022

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“…Furthermore, DDX46 silencing in esophageal squamous cell carcinoma, cutaneous squamous cell carcinoma and gastric cancer cells also restrains their proliferative capacity (Chen et al, 2021;Li et al, 2016;Lin et al, 2020). Our breast and colon cancers (Greco et al, 2001;Malaterre et al, 2007;Zorbas et al, 1999). Overexpression of c-Myb has been demonstrated to serve an important role on the proliferation and migration of breast cancer cells (Dúcka et al, 2021;Jia et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

The role of DDX46 in breast cancer proliferation and invasiveness: A potential therapeutic target

Song

Hua

et al. 2022

Cell Biology International

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DDX46, a member of DEAD-box (DDX) proteins, is associated with various cancers, while its involvement in the pathogenesis of breast cancer hasn't been reported so far. The study demonstrated the overexpression of DDX46 in human breast cancer cells and tissue samples, and correlated with high histological grade and lymph node metastasis. Downregulation of DDX46 in the breast cancer cell lines inhibited their proliferation and invasiveness in vitro. Furthermore, the growth of MDA-MB-231 xenografts was suppressed in nude mice by DDX46 knockingdown. Taken together, our findings suggest that DDX46 is an oncogenic factor in human breast cancer, and a potential therapeutic target.

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