C Orrelation of Thyroid Dysfunction With Insulin Resistance in Obese Women

Abstract

Thyroid dysfunction will be associated with insulin resistance in obese women were common. METHODS: In this cross-sectional study, a total of fifty female subjects with age group of 30-60 years, a whose body mass index was above 30 kg/m 2 were studied for 16 months between July 2013 to November 2014 who were attending general medicine OPD in Siddartha Medical College, Tumkur were studied. Subjects with known disease or disorder of endocrine systems or who were receiving medications like, thyroid hormones preparations, Lithium, Amiodarone or corticosteroids were excluded. Blood samples were assed for T3, T4, TSH, FBS, Fasting Insulin and HOMA IR was calculated. RESULTS: The mean age of the patients was 31.4±7.32 years. Among these subjects TSH analysis revealed that 26% were having subclinical hypothyroidism (SH). We found that 46% (remaining) of these SH subjects are having insulin resistance while 24% of patients with normal thyroid function are having insulin resistance as estimated by HOMA IR. P-value=0.6 and the odds ratio is 0.667, with a 95% confidence interval extending from 0.19 to 2.09. The observed difference in insulin resistance was not statistically between the subjects with SH and normal obese subjects. CONCLUSION: Insulin resistance co exists with thyroid-hypo function in 46% of obese patients it is necessary to do routinely thyroid profile and insulin resistance in all the patients.