C-peptide Improves Hyperglycemia-induced Endothelial Redox Balance by Preventing Mitochondrial Oxidative Stress and Enhancing NADPH Synthesis

Abstract

C-peptide improves hyperglycemia-induced endothelial redox balance by preventing mitochondrial oxidative stress and enhancing NADPH synthesis Himani Vejandla C-peptide, a by-product of insulin biosynthesis, has been shown to ameliorate diabetes-induced renal impairment. Yet, the mechanisms underlying this protective benefit remain unclear. Our studies have shown that C-peptide improved renal LIST OF ABBREVIATIONS AGE Advanced Glycation End-products AMDCC American Models of Diabetic Complications consortium cAMP Cyclic Adenosine Mono Phosphate CAT Catalase