C-reactive protein and its relation to high blood pressure in overweight or obese children and adolescents

Abstract

OBJECTIVE To investigate the association between C-reactive protein (CRP) and high blood pressure (BP) in overweight or obese children and adolescents. METHODS Cross-sectional study with 184 overweight or obese children and adolescents aged from two to 18 years old, from April, 2009 to April, 2010. The classification of nutritional status used the body mass index (BMI). Based on the Centers for Disease Control and Prevention curve, individuals were classified as: overweight (BMI between the 85th-95th percentiles), obesity (BMI between 95th-97th percentiles) and severe obesity (BMI >97th percentile). Abnormal values were considered for systolic BP (SBP) and/or diastolic (DBP) if ≥90th percentile of the BP curve recommended for children and adolescents in the V Brazilian Guidelines on Hypertension, for waist circumference (WC) if ≥90th percentile of the curve established by the National Cholesterol Education Program, and for high sensitive CRP (hs-CRP) if >3mg/dL. To evaluate the association of inadequate values of CRP and the studied groups, chi-square test and analysis of variance were applied, using the Statistical Package for the Social Sciences version 17.0 and adopting a significance level of 5%. RESULTS Among the evaluated sample, 66.3% were female, 63.5%, non-white, 64.1% had severe obesity, 78.3% had altered WC and 70.6% presented high BP. There was a significant association of CRP high levels with altered WC and BMI ≥97th percentile. In adolescents, high CRP was related to high SBP. CRP mean values were higher in individuals with elevated SBP. CONCLUSIONS Inadequate values of hs-CRP were associated with severe obesity and high SBP in the studied population. These markers can be used to identify children and adolescents at higher risk for developing atherosclerosis.

Obesity and Diabetes Mellitus Adversely Affect Outcomes after Cardiac Surgery in Children's Hospitals

“…[13][14][15][16][17] In addition, recent clinical investigations continue to provide insight into the proinflammatory mechanisms of disease and morbidities in obesity and diabetes mellitus in children and adults. [18][19][20] Obesity-related morbidities and healthcare costs are increasing 7 while congenital heart surgery outcomes continue to improve. Although this study did not demonstrate a difference in survival after cardiac surgery in those with obesity and/or diabetes mellitus, we did find that these patients had more morbidity and increased hospital utilization than those without obesity and/or diabetes mellitus.…”

Is the Childhood Primary Hypertension Causes Target Organ Damage?

“…26 hsCRP seviyelerinin de diğer faktörlerden bağımsız olarak hipertansif hastalarda yükseldiği gösterilmiştir. [27][28][29] Çalışmamızda hsCRP ve Lp(a) değerleri evre 2 hipertansiyonlu grupta anlamlı olarak daha yüksek bulundu. Tüm hasta grubunda inflamasyon parametreleri yüksek olan hastaların fonksiyonel olarak KVS değişikliklerinin diğer gruba göre daha fazla olduğu saptandı.…”

Pathophysiology of hypertension in obese children: a systematic review

“…C-reactive protein (CRP) is an inflammatory marker and is considered a marker for atherosclerosis. Although two studies found a significant association between CRP and blood pressure in obese children, independently of BMI (62,63), one study did not (64).…”