C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia

Fernandes, Andreia; Tábuas‐Pereira, Miguel; Duro, Diana; Lima, Marisa; Gens, Helena; Santiago, Beatriz; Durães, João; Almeida, Maria Rosário; Leitão, Maria João; Baldeiras, Inês; Santana, Isabel

doi:10.1016/j.exger.2020.111004

Cited by 23 publications

(18 citation statements)

References 56 publications

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“…Since the criterion in previous studies was dementia, the results of those studies could be different from ours [ 7 , 8 ]. This possibility is supported by some findings suggesting that CRP levels could be different in different stages of disease [ 33 ]. In addition, variations across different cohorts could provide an explanation.…”

Section: Discussionsupporting

confidence: 55%

Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea

et al. 2021

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Background: Both cardiovascular health (CVH) and inflammation associated with cognition, and inflammation also associated with cardiovascular health. However, related information in the Korean population is limited. The objective of our study was to confirm the influence of inflammation on the association between CVH and cognition in cross-sectional design. Methods: Data were obtained from the Cardiovascular and Metabolic Diseases Etiology Research Center baseline study. Participants who completed fasting serum analysis, questionnaires, and cognitive function tests were included in the analysis, whereas those with a history of autoimmune disease were excluded. CVH in Ambulatory Care Research Team health index metrics, including smoking, physical activity, healthy diet, obesity, history of hypertension, and diabetes, were used to assess CVH. Cognitive function was evaluated with the Korean version of the Mini-Mental State Estimation for Dementia Screening (MMSE-DS). Inflammatory status was assessed based on a high-sensitivity C-reactive protein (hs-CRP) test. Results: Among 2,622 total participants (mean age 57.2 years; 1,792 women), 13%, 58%, and 29% had poor, intermediate, or ideal CVH, respectively. Logistic regression analysis demonstrated that CVH was significantly associated with cognitive function only in women. Stratified analysis stated that cognitive impairment due to CVH doesn't have an association with hs-CRP level. When conducted same analyses for each CVH component, the only E p u b a h e a d o f p r i n t 2 component affecting the association was hypertension history in men.Conclusions: Overall, CVH is not significantly associated with cognitive decline in the middle-aged Korean population. Also, the modifying role of inflammation was not significant in CVH and cognition.

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Section: Discussionsupporting

confidence: 55%

Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea

et al. 2021

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“…A recent publication from Berger and colleagues evaluated the proteomic changes in the CSF of AD Neuroimaging Initiative (ADNI) samples by applying linear regression models adjusted by age, sex, APOE4 copy number, and linear models to adjust by AD clinical status or CSF levels of Aβ or tau. The authors observed that increasing APOE4 copy number was related to decreased CSF levels of C-reactive protein (a classical inflammatory marker), which correlated with cognitive impairment and AD progression [ 203 , 204 ]. The study by Cruchaga and colleagues examined the correlation between CSF and plasma apoE levels in 641 AD patients and controls, in which they found a very low correlation [ 205 ].…”

Section: Distribution Of Apoe In the Brain Cerebrospinal Fluid And Bloodmentioning

confidence: 99%

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Fernández-Calle

Konings

Frontiñán-Rubio

et al. 2022

Mol Neurodegeneration

115

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ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's disease (AD). Neuroinflammation has become the third hallmark of AD, together with Amyloid-β plaques and neurofibrillary tangles of hyperphosphorylated aggregated tau protein. This review aims to broadly and extensively describe the differential aspects concerning apoE. Starting from the evolution of apoE to how APOE's single-nucleotide polymorphisms affect its structure, function, and involvement during health and disease. This review reflects on how APOE's polymorphisms impact critical aspects of AD pathology, such as the neuroinflammatory response, particularly the effect of APOE on astrocytic and microglial function and microglial dynamics, synaptic function, amyloid-β load, tau pathology, autophagy, and cell–cell communication. We discuss influential factors affecting AD pathology combined with the APOE genotype, such as sex, age, diet, physical exercise, current therapies and clinical trials in the AD field. The impact of the APOE genotype in other neurodegenerative diseases characterized by overt inflammation, e.g., alpha- synucleinopathies and Parkinson's disease, traumatic brain injury, stroke, amyotrophic lateral sclerosis, and multiple sclerosis, is also addressed. Therefore, this review gathers the most relevant findings related to the APOE genotype up to date and its implications on AD and CNS pathologies to provide a deeper understanding of the knowledge in the APOE field.

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“…The association with CRP was stronger in MCR cases with memory impairment [16] . On the other hand, several studies have associated CRP and IL-6 levels to presence of MCI and risk of conversion to dementia [35] , [36] , [37] .…”

Section: Discussionmentioning

confidence: 99%

Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey

Groeger

Ayers²,

Barzilai³

et al. 2022

Cerebral Circulation - Cognition and Behavior

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C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia

Cited by 23 publications

References 56 publications

Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea

Exploring the associations between cardiovascular health measured with the CANHEART model and early cognitive impairment in a middle-aged population in Korea

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Inflammatory biomarkers and motoric cognitive risk syndrome: Multicohort survey

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