C-reactive protein concentration as a prognostic factor for inflammation in the management of odontogenic infections

Mirochnik, Roman; Araida, S.; Yaffe, Victoria; El-Naaj, Imad Abu

doi:10.1016/j.bjoms.2017.10.006

Cited by 16 publications

(7 citation statements)

References 8 publications

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“…He observed a strong co-relation between the CRP levels and clinical parameters to the severity of infection 3. Similar results were observed by Singh TW et al,Mirochnik R et al and Stathopoulos P et al in their clinical studies where CRP was an effective indicator of hospital stay, severity of infection 4,5,6.…”

supporting

confidence: 75%

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Beena¹,

Thomas²,

Bhargava³

et al. 2021

ijocd

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Purpose: The aim of this study was to evaluate the role of C-reactive protein (CRP), Total Leukocyte Count(TLC) and Erythrocyte Sedimentation Rate (ESR) levels as diagnostic and prognostic indicators in patientsdiagnosed with maxillofacial odontogenic infections.Materials and Methods: A prospective study was done among 30 patients with maxillofacial odontogenicinfections. Blood samples were collected at 3 intervals to detect the level of the study parameters followedby incision and drainage for all the patients under Local anesthesia.Results: The mean CRP, TLC and ESR levels gradually reduced on 5th post-operative day as compared today 1 and 3 suggestive of resolution of the infectious state.Conclusion: We conclude that CRP is required only in selective cases of maxillofacial infection wheremonitoring under intensive care will be required, else TLC alone is sufficient to indicate the presence ofinfection along with adequate medical and surgical care.

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supporting

confidence: 75%

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Beena¹,

Thomas²,

Bhargava³

et al. 2021

ijocd

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“…This nding is in contrast to previous studies that have demonstrated a relationship between CRP levels and factors such as the length of hospitalization, the number of spaces involved, and the rate of reoperation in OMSI patients. 15,17,27 In our study cohort, 82.6% of patients had abnormal CRP levels. This high prevalence can be attributed to the fact that CRP is a highly sensitive and responsive indicator of acute infection.…”

Section: Discussionmentioning

confidence: 63%

When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

Liu,

Zhu,

Qin

et al. 2023

Preprint

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Objective: Patients with mild oral and maxillofacial space infection (OMSI) usually need only antimicrobial therapy. However, surgical intervention is eventually needed after using antibiotics for a period. The objective of this study was to explore the risk factors for drug therapy failure in OMSI. Subjects and methods: A retrospective case‒control study was designed. From August 2020 to September 2022, patients at Shanghai Jiao Tong University Affiliated Ninth People's Hospital who were diagnosed with OMSI were retrospectively reviewed. The outcome variable was surgical intervention after the use of antibiotics. We collected common biological factors, including demographic characteristics, routine blood test results, C-reactive protein (CRP) levels and composite indicators, such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). The χ2 test and binary logistic regression were used to examine the association between biological factors and the outcome variable. Results: Forty-six patients were included in this study. Further surgical intervention was needed in 20 patients (43.5%). The NLR showed a significant association with further surgical drainage (p=0.01). A binary logistic regression equation was found by using stepwise regression based on the Akaike information criterion (R2=0.443), which was associated with sex (odds ratio [OR], 0.216; p=0.092), NLR (OR, 1.258; p=0.045), red blood cell (RBC) count (OR, 4.372; p=0.103) and monocyte (MONO) count (OR, 9.528, p=0.023). Receiver operating characteristic analysis produced an area under the curve for NLR of 0.725 (p=0.01) and for the binary logistic regression model of 0.8365 (p<0.001). Conclusion: Surgical interventions are needed in some mild OMSI patients when antimicrobial therapy fails to stop the formation of abscesses. The binary logistic regression model shows that NLR can be used as an ideal prognostic factor to predict the outcome of antimicrobial therapy and the possibility of requiring surgical intervention. Statement of clinical relevance: Using simple, inexpensive, and easily achieved biological parameters (such as routine blood test results) and composite indicators calculated by them (such as NLR) to predict whether surgical intervention is needed in the future provides a reference for clinical doctors and enables more cost-effective and efficient diagnosis and treatment.

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“… 40 The significant increase in the CRP level of the diabetic control group might be due to inflammation of the pancreas. 41 This suggests a chronic hyperglycaemia which has been reported to increase the circulating inflammatory biomarkers. 42 The significant decrease in CRP level of the extract treated diabetic rats suggests that the extract ameliorated inflammation and prevent secondary complications via reduction of CRP level.…”

Section: Discussionmentioning

confidence: 97%

Chromatographic fractions from Chrysophyllum albidum stem bark boost antioxidant enzyme activity and ameliorate some markers of diabetes complications

Yusuf

Yakubu²,

Akanji³

2021

Journal of Traditional and Complementary Medicine

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Background and aim Diabetes, with hyperglycaemia as hallmark, is a global crisis that reduces the antioxidant status and produces complications when poorly managed. The development of complications can be indicated by inflammation, lipid peroxidation and the accumulation of glycation adducts. Thus, the attenuation of hyperglycaemia and boosting of antioxidants status is key in ameliorating markers of diabetes complications. This work evaluated the potency of Chrysophyllum albidum stem bark on some markers of diabetes complications. Experimental procedure A total of 100 female rats (180.80 ± 8.50 g) were assigned into ten groups of ten animals each; control received 1.0 ml of distilled water while those in groups DC, RD, F1, F3, F4, F5, F7, F9, F10 were induced into diabetes by intraperitoneal administration of 120 mg/kg body weight of alloxan and were orally administered distilled water, glibenclamide, 2.5 mg/kg of the chromatographic fractions 1, 3, 4, 5, 7, 9, and 10 respectively, once daily for 14 days. F7 was profiled for its bioactive constituents and the pancreas histology of the rats were examined. Results Chromatographic fractions F5 and F7 significantly decreased fasting blood glucose, glycosylated haemoglobin, C-reactive protein, total cholesterol, triglycerides, atherogenic index, malondialdehyde while insulin, high density lipoprotein, catalase, superoxide dismutase activities significantly increased. Fraction F7 revealed eight compounds and restored the distorted pancreas. Conclusion Fraction F7 ameliorated the markers of diabetes complications considered in this study better than F5, restored the compromised pancreas and can be explored as lead candidate for production of drug for the management of diabetes.

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C-reactive protein concentration as a prognostic factor for inflammation in the management of odontogenic infections

Cited by 16 publications

References 8 publications

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

Role of C-reactive Protein, Total Leukocyte count and Erythrocyte Sedimentation Rate as a Diagnostic and Prognostic Indicator in Maxillofacial Infections

When is surgical intervention needed in oral and maxillofacial space infection patients? A retrospective case control study in 46 patients

Chromatographic fractions from Chrysophyllum albidum stem bark boost antioxidant enzyme activity and ameliorate some markers of diabetes complications

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