C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population

Atisha‐Fregoso, Yemil; Lima, Guadalupe; Carrillo-Maravilla, Eduardo; Posadas-Sánchez, Rosalinda; Pérez-Hernández, Nonanzit; Baños-Peláez, Miguel; Iturralde-Chávez, Alejandra; Hernández-Díaz, Nora; Jakez‐Ocampo, Juan; Rodrı́guez-Pérez, José Manuel; Vargas‐Alarcón, Gilberto; Llórente, Luis; Romero-Díaz, Juanita

doi:10.1007/s10067-018-4059-5

Cited by 11 publications

(7 citation statements)

References 42 publications

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“…Some pro-inflammatory pathogens increased accompanied with the intestinal mucosal barrier compromised, which lead to more bacterial LPS transferring into lymph nodes and blood to stimulate the TOLL-like pathway of the host cells, and produce inflammatory cytokine (62). SLE patients generally used massive immunosuppressive agents and glucocorticoids during the active period, which could inhibit the immune system and might cause a large increase in opportunistic pathogens (63,64).…”

Section: Supportive Of a Role Formentioning

confidence: 99%

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus

et al. 2019

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Intestinal dysbiosis is implicated in Systemic Lupus Erythematosus (SLE). However, the evidence of gut microbiome changes in SLE is limited, and the association of changed gut microbiome with the activity of SLE, as well as its functional relevance with SLE still remains unknown. Here, we sequenced 16S rRNA amplicon on fecal samples from 40 SLE patients (19 active patients, 21 remissive patients), 20 disease controls (Rheumatoid Arthritis (RA) patients), and 22 healthy controls (HCs), and investigated the association of functional categories with taxonomic composition by Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt). We demonstrated SLE patients, particularly the active patients, had significant dysbiosis in gut microbiota with reduced bacterial diversity and biased community constitutions. Amongst the disordered microbiota, the genera Streptococcus, Campylobacter, Veillonella, the species anginosus and dispar, were positively correlated with lupus activity, while the genus Bifidobacterium was negatively associated with the disease activity. PICRUSt analysis showed metabolic pathways were different between SLE and HCs, and also between active and remissive SLE patients. Moreover, we revealed that a random forest model could distinguish SLE from RA and HCs (area under the curve (AUC) = 0.792), and another random forest model could well predict the activity of SLE patients (AUC = 0.811). In summary, SLE patients, especially the active patients, show an apparent dysbiosis in gut microbiota and its related metabolic pathways. Amongst the disordered microflora, four genera and two species are associated with lupus activity. Furthermore, the random forest models are able to diagnose SLE and predict disease activity.

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Section: Supportive Of a Role Formentioning

confidence: 99%

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus

et al. 2019

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“…The SNP is associated with serum CRP concentrations as suggested by previous studies [35]. The variant of CRP is associated with increased serum CRP levels while others are associated with decreased ones [37][38][39].…”

Section: Selection Of Snps Genotyped In This Studymentioning

confidence: 54%

Association Of Inflammation Gene Polymorphism With Increased Risk Of Metabolic Syndrome In Tatar Ethnic Group

2022

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Background and objective — Chronic low-grade inflammation plays an important role in pathophysiology of metabolic syndrome (MetS). The aim of our study was to determine the associations of polymorphic variants of inflammation genes with MetS and serum levels of high-sensitivity C-reactive protein (hsCRP) and tumor necrosis factor-α (TNF-α) in Tatar patients (Bashkortostan). Methods — In our case-control cross-sectional study, 271 MetS patients and 327 healthy Tatars were genotyped for the SNPs in CRP, TNFA, LTA, TNFRSF1B genes. Results — TNFRSF1B (rs1061624) was associated with the MetS [odds ratio (OR)=0.49, рADJ=0.0034] and TNF-α level (p=0.033). TNFA (rs1800629) was associated with TNF-α (p=0.015), albuminuria (p=0.013). CRP (rs2794521) was associated with fasting (p=0.0096) and postprandial (p=0.01) insulin, HOMA-IR (homeostasis model assessment of insulin resistance, p=0.0019), hsCRP (p=0.036), waist-hip ratio (WHR, p=0.007), body mass index (BMI, p=0.039). The participants having the C-C haplotype of CRP rs2794521-rs1130864 were more common among MetS patients (OR=1.99, p=0.032). T-T haplotype in CRP was associated with hsCRP (p=0.0043), low-density lipoprotein cholesterol (p=0.025), HOMA-IR (p=0.00029), glycated hemoglobin (p=0.006), postprandial (p=0.0006) and fasting insulin (p=0.00031), WHR (p=0.00012), BMI (p=0.00024). Conclusions — The data confirms that the variants of inflammation genes CRP, TNFA, TNFRSF1B are associated with levels of TNF-α, hsCRP. Novel association of TNFRSF1B (rs1061624) with MetS had been identified.

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“…It has been proposed that an alteration in CRP production occurs in SLE, which could induce high CRP levels. The altered levels of CRP in SLE could be related its physiopathology or to the presence of some genetic variants, such as −717 A > G (rs2794521), −409 G > A (rs3093062), +1444 C > T (rs1130864), and +1846 C > T (rs1205) in the CRP gene [ 50 ].…”

Section: Cardiovascular Disease Risk Factors In Slementioning

confidence: 99%

Nutritional Approaches to Modulate Cardiovascular Disease Risk in Systemic Lupus Erythematosus: A Literature Review

et al. 2023

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Systemic lupus erythematosus (SLE) is a chronic pathology characterized by a bimodal mortality pattern attributed to clinical disease activity and cardiovascular disease (CVD). A complex interaction between traditional CVD risk factors such as obesity, dyslipidemia, smoking, insulin resistance, metabolic syndrome, and hypertension, as well as the presence of non-traditional CVD risk factors such as hyperhomocysteinemia, pro-inflammatory cytokines, and C-reactive protein levels, has been suggested as a cause of the high prevalence of CVD in SLE patients. On the other hand, environmental factors, such as nutritional status, could influence the disease’s prognosis; several nutrients have immunomodulators, antioxidants, and anti-cardiometabolic risk properties which could reduce SLE severity and organ damage by decreasing the development of traditional and non-traditional CVD risk factors. Therefore, this critical literature review discusses the therapeutic potential of nutritional approaches that could modulate the development of the main comorbidities related to CVD risk in SLE patients.

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C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population

Cited by 11 publications

References 42 publications

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus

Disordered intestinal microbes are associated with the activity of Systemic Lupus Erythematosus

Association Of Inflammation Gene Polymorphism With Increased Risk Of Metabolic Syndrome In Tatar Ethnic Group

Nutritional Approaches to Modulate Cardiovascular Disease Risk in Systemic Lupus Erythematosus: A Literature Review

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