C‐reactive protein gene polymorphisms (rs1205) in Asian Indian patients with Takayasu arteritis: Associations and phenotype correlations

Nair, Aswin; Goel, Ruchika; Hindhumati, Mohan; Shah, Krati; Chandana, Puneet; Jayaseelan, Visalakshi; Kabeerdoss, Jayakanthan; Joseph, George; Danda, Sumita; Danda, Debashish

doi:10.1111/1756-185x.13180

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…In addition, we made the interesting observation that the percentage of TT genotype increased with the severity of infantile sepsis, while the percentage of CT genotype decreased with the severity of infantile sepsis. The genotypes changes of CRP SNP rs1205 have also been previously reported in Takayasu arteritis patients [ 22 ].…”

Section: Discussionmentioning

confidence: 64%

“…To the best of our knowledge, this is the first genetic association study to report on the relationship between CRP gene SNPs and infantile sepsis risk. The rs1205 SNP encodes for a functional variant of CRP and is widely reported in many diseases, including psoriasis, colorectal cancer, Takayasu arteritis, and diabetes [ 19 – 22 ]. Our results showed that there was no difference between rs1205 in the CRP gene and sepsis, which is in agreement with most previous reports in other diseases.…”

Section: Discussionmentioning

confidence: 99%

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Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China

et al. 2018

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BackgroundC-reactive protein (CRP) is an important biomarker of sepsis. Several single-nucleotide polymorphisms (SNPs) in the CRP gene can determine plasma CRP levels and are risk factors in many diseases, such as cancer, arteritis, and diabetes. However, it is unknown whether polymorphisms in CRP are associated with susceptibility to and outcome of infantile sepsis. We explored the effect of these SNPs on CRP response in infantile sepsis, and compared genetic data on patients with sepsis.Material/MethodsA total of 49 infants with sepsis and 20 healthy infants were enrolled during hospitalization, and 3 SNPs in the CRP gene region (rs1205, rs2808530, and rs3091244) were genotyped and then analyzed for associations with CRP levels and sepsis.ResultsThe CRP means concentration results showed that mean CRP concentration was different in the 4 groups (healthy, sepsis, severe sepsis, and septic shock) and was positively correlated with the severity of infantile sepsis. There was also a difference in CRP SNP rs1205 between infants with septic shock and healthy infants, and between infants with septic shock and infants with sepsis. No differences were observed in SNP rs2808630 and SNP rs3091244.ConclusionsOur study suggests that rs1205 genetic variability in the CRP gene determines the CRP levels in sepsis of different severities, while SNP rs3091244 and SNP rs2808630 are not associated with sepsis. However, the results of the present study on SNP rs1205, rs3091244, and rs2808630 in the CRP gene should be interpreted with caution due to limited sample size and sample heterogeneity. Large-scale, well-designed studies are needed to validate our findings.

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China

et al. 2018

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“…A Tunisian CSU study showed there was a CRP high concentration remission after desloratadine therapy . Meanwhile, articles on the study of CRP gene polymorphisms indicate that CRP genetic variants (such as rs1800947, rs1205 and rs3093059) are associated with disease, including stroke, Takayasu arteritis and HBV‐related liver cancer . Thus, we investigate whether CRP gene polymorphisms influence drug therapy and disease risk.…”

Section: Discussionmentioning

confidence: 99%

C‐reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level

Yan

Chen

Peng

et al. 2019

Experimental Dermatology

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Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema, and nearly 35% patients respond poorly to non‐sedating H1 antihistamine treatment. CRP gene encodes the C‐reactive protein, which is involved in the pathogenesis of CSU. To investigate the impacts of CRP polymorphisms on the susceptibility and therapeutic efficacy in the South Han CSU patients, we enrolled 145 CSU patients in our study. After 4‐week non‐sedating H1 antihistamine monotherapy treatment, more than 50% reduction of the severity score is considered as effective, or else non‐effective. The CRP rs3093059T/C and rs2794521G/A genotypes of patients were determined by Sequenom MassARRAY. Functional studies including relative luciferase assay and β‐hexosaminidase assay were conducted in HEK293T cells or RBL‐2H3 cells to explore the function of variants. Forty (62.50%) CSU patients were effective when treated with mizolastine, and 55 (72.4%) patients were effective in the desloratadine group. We found that the patients carried with rs3093059TT genotype were significantly associated with good response (OR = 4.20, P = 0.015), had lower serum CRP, IL‐6 and TNF‐α levels than the CT/CC genotypes. In vitro, the rs3093059C allele exhibited significantly higher luciferase activity than wild allele (P < 0.001). From the β‐hexosaminidase assay, we observed the inhibiting degranulation effects by mizolastine and this effect is weakened when with a higher dose CRP in RBL‐2H3 cells. Our findings suggested that CSU patients carrying the rs3093059C allele may respond poorly to mizolastine with elevated serum CRP level.

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“…Based on genome-wide association studies (GWASs) relevant to CRP [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38], the SNPs that could affect serum level of CRP were selected and included in this investigation. We also included SNPs with a confirmed association with inflammatory disorders [39][40][41][42][43]. Finally, rs11265260, rs1205, rs12093699, rs1800947, rs2794520, rs1341665, rs3093059, rs3093068, rs3122012, rs7553007, and rs1130864 were assessed in this study.…”

Section: Selection Of Genetic Locimentioning

confidence: 99%

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients

Wang

Zhou

et al. 2020

Exp Clin Endocrinol Diabetes

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Purpose This study was aimed to discover the combined effects of single nucleotide polymorphisms (SNPs) within the C-reactive protein (CRP) gene and potential environmental factors on the risk and prognosis for diabetic foot osteomyelitis (DFO). Methods A total of 1734 diabetes mellitus patients, 681 with DFO and 1053 without DFO, were successfully recruited, as well as 1261 healthy control individuals. Participants data were recorded regarding age, gender, smoking and drinking history, body mass index (BMI), hypertension, cacosmia, and ulceration. A total of 11 SNPs within the CRP gene were designated for exploration, by logistic regression analyses, of how they might interact with environmental factors to affect susceptibility to DFO. Results Frequencies of smoking and drinking, and incidence of hypertension, cacosmia, or ulceration displayed marked differences (all P<0.05) between DFO and non-DFO patients. Furthermore, allele G of rs11265260 (A>G), allele G of rs1800947 (C>G), and allele T of rs3093059 (T>C) and rs1130864 (C>T) exhibited a trend to increase risk of DFO (all P<0.05). Allele G of rs11265260 (A>G), allele G of rs1800947 (C>G) and rs3093068 (G>C), and allele T of rs1130864 (C>T) were significant predictors of poor prognosis among DFO patients (P<0.05). In addition, genotypes of rs11265260 (i.e., GG and AG), rs1800947 (i.e., CG and GG), rs3093059 (i.e., TT) and rs113084 (i.e., CT and TT) amplified the influence of smoking, alcohol consumption, cacosmia, and ulceration on progression from non-DFO to DFO (all γ>1). Conclusion Genetic mutations within CRP functioned interactively with external factors to affect DFO risk.

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C‐reactive protein gene polymorphisms (rs1205) in Asian Indian patients with Takayasu arteritis: Associations and phenotype correlations

Abstract: T allele of rs1205 in CRP gene was less frequent in TA. CC genotype was associated with involvement of coronary arteries and ascending aorta. CC genotype was less commonly associated with blunted CRP response (CT + TT > CC).

Cited by 8 publications

References 30 publications

Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China

Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China

C‐reactive protein (CRP) rs3093059C predicts poor mizolastine response in chronic spontaneous urticaria patients with elevated serum CRP level

Combined Effects of Single Nucleotide Polymorphisms (SNPs) within C-reactive Protein (CRP) and Environmental Parameters on Risk and Prognosis for Diabetic Foot Osteomyelitis Patients

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