C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol

Kazumi, Tsutomu; Kawaguchi, Akira T.; Hirano, Tsutomu; Yoshino, Gen

doi:10.1016/s0026-0495(03)00184-7

Cited by 103 publications

(75 citation statements)

References 40 publications

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“…9 However, this might be explained by the higher mean BMI in CC and GC genotypes. In this study, BMI was positively correlated with CRP level (R ¼ 0.199, Po0.001) in line with earlier reports, 23,24 and this was seen also when adjusting for À174 G/C genotype (R ¼ 0.186, Po0.001). In addition, the correlation between À174 G/C genotype and CRP level (R ¼ À0.109, P ¼ 0.02) was not present after adjustment for BMI (R ¼ À0.09, P ¼ 0.06).…”

Section: Study Populationsupporting

confidence: 93%

“…10,32 In this study, there was no correlation between serum IL-6 levels and the À174 G/C genotype. An association between the À174 C allele and low circulating levels of IL-6 has been shown in some 11,23,33,34 but not all 31,35 studies. There are several possible reasons that the association between the À174 G/C genotype and circulating IL-6 is variable.…”

Section: Discussionmentioning

confidence: 99%

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A common polymorphism in the interleukin-6 gene promoter is associated with overweight

et al. 2004

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OBJECTIVE:Human body fat mass is to a large extent genetically determined, but little is known about the susceptibility genes for common obesity. Interleukin-6 (IL-6) suppresses body fat mass in rodents, and IL-6 treatment increases energy expenditure in both rodents and humans. The À174 G/C single-nucleotide polymorphism (SNP) in the IL-6 gene promoter is common in many populations, and À174 C-containing promoters have been found to be weaker enhancers of transcription. Moreover, a SNP at position À572 in the IL-6 promoter has recently been reported to affect transcription. The objective was to investigate the association between the IL-6 gene promoter SNPs and obesity. DESIGN: Trans-sectional association study of IL-6 gene promoter SNPs and indices of obesity. SUBJECTS: Two study populations, the larger one consisting of hypertensive individuals (mean age 57 y, 73% males, n ¼ 485) and the other consisting of 20 y younger nonobese healthy females (n ¼ 74). MEASUREMENTS: Genotyping for the À174 IL-6 G/C and the À572 G/C SNPs, body mass index (BMI), serum leptin levels, serum IL-6 levels, C-reactive protein, fasting blood glucose and various blood lipids. RESULTS: The common À174 C allele (f C ¼ 0.46), but not any À572 allele, was associated with higher BMI and higher serum leptin levels in both study populations. In the larger population, there were significant odds ratios for the association of CC (2.13) and GC (1.76) genotypes with overweight (BMI425 kg/m 2 ). Moreover, as the C allele was common, it accounted for a significant population-attributable risk of overweight (12%; CI 2-21%), although its average effect was modest in this sample. CONCLUSION: Genetically determined individual differences in production of IL-6 may be relevant for the regulation of body fat mass.

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Section: Study Populationsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

A common polymorphism in the interleukin-6 gene promoter is associated with overweight

et al. 2004

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“…Our results confirm previous reports demonstrating direct relationships with apolipoprotein B 15,17 and inverse relationships with apolipoprotein AI, 17,54 although the evidence is inconsistent. 15,54 In the current study, the relationship with apolipoprotein B remained significant in multiple regression after controlling for the effect of body fat, triglycerides, and HRT use. However, neither apolipoprotein was consistently associated with CRP after controlling for genetic factors.…”

Section: Greenfield Et Al C-reactive Protein and Obesity 3025supporting

confidence: 87%

Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences

et al. 2004

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Background-C-reactive protein (CRP) values predict atherothrombotic cardiovascular disease and type 2 diabetes mellitus. Associations between CRP and obesity, predominantly assessed anthropometrically, may partly explain these observations. Previous studies have been unable to control for genetic influences on CRP and obesity. The aim of this study was to examine the relationship between CRP and accurately measured body fat, lipids, apolipoproteins, blood pressure, and environmental and behavioral factors, independent of genetic influences. Methods and Results-One

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“…The fourth new finding of this investigation relates to the role of hyperleptinemia in causing chronic low-grade inflammation and secretions of pro-inflammatory CVD markers [21,28,34,42]. Although a positive relationship between hyperleptinemia and high levels of IL-6 and CRP have been observed in obese patients, experimental evidence that peripheral actions of leptin on targets in the periphery engenders these relationships is scarce.…”

Section: Discussionmentioning

confidence: 99%

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

Dube¹,

Torto²,

Kalra³

2008

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Low-grade systemic inflammation, as indicated by increased circulating levels of inflammatory markers CRP and IL-6, is linked to increased risks for cardiovascular diseases (CVD) and diabetes mellitus in obese subjects. Whereas hyperleptinemia in obesity are associated with increased CRP and IL-6 release, the hypothalamic versus peripheral site of leptin action has not been ascertained. The effects of increased leptin supply selectively in the hypothalamus by gene therapy on proinflammatory CRP and IL-6 levels and on markers of diabetes in the circulation of ob/ob mice displaying either age-related or dietary obesity were assessed. A recombinant adeno-associated viral vector encoding either green fluorescent protein (control) or leptin gene was injected intracerebroventricularly. Five weeks later, one-half of each of the vector groups was switched to high-fat diet consumption and the other half continued to consume regular low-fat chow diet. Body weight and visceral white adipose tissue were drastically reduced and hyperinsulinemia and hyperglycemia were abrogated by leptin gene therapy, independent of the dietary fat content. The elevated plasma CRP and IL-6 levels seen in obese ob/ob mice receiving the control vector, regardless of the fat content of the diet, were markedly suppressed by increased hypothalamic leptin in both groups. The results show for the first time that leptin deficiency elevates and reinstatement of leptin selectively in the hypothalamus suppresses the release of pro-inflammatory biomarkers, a response likely to alleviate CVD associated with obesity.

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C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol

Cited by 103 publications

References 40 publications

A common polymorphism in the interleukin-6 gene promoter is associated with overweight

A common polymorphism in the interleukin-6 gene promoter is associated with overweight

Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences

Increased leptin expression selectively in the hypothalamus suppresses inflammatory markers CRP and IL-6 in leptin-deficient diabetic obese mice

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