Objective: The objective of the study was to evaluate incidence of C-shaped canals in mandibular second molars using Cone Beam Computed Tomography. Study Design: Cross Sectional, Descriptive study. Place and Duration: This study was undertaken in Department of Radiology, Rehman College of Dentistry, Peshawar, from 15th June 2022 till 15th December 2022. Methodology: Cone Beam Computed Tomography scans of 60 patients of both genders between 18 and 60 years of age were studied for the presence of C-shaped canals in mandibular 2nd molars. Results were analyzed with the help of SPSS version 21. Chi-square was applied for comparison of male and female groups. Results: Cone Beam Computed Tomography scans of 60 patients of both genders between 18 and 60 years of age were studied for the presence of C-shaped canals in mandibular 2nd molars. Results were analyzed with the help of SPSS (version 21). Chi-square was applied for comparison of male and female groups (p > 0.05). Conclusion: Incidence of C-shaped canal is high in patients with mandibular 2nd molars. Endodontists need to be vigilant for the existence of C-shaped canals and proper imaging of these canals is essential for successful endodontic treatment. Keywords: Root Canal Therapy, Molar, C-Shaped Canals, Pulp, Cone Beam Computed Tomography, Endodontic. How to Cite This: Rehman AZ, Alam S, Khan IA, Arbab KN, Khalid MD, Askar H. Incidence of C-shaped canals in mandibular second molars in patients Visiting Rehman College of Dentistry, Khyber Pakhtunkhwa (KPK), Pakistan. Isra Med J. 2023; 15(2): 70-73. DOI: https://doi.org/10.55282/imj.oa1373