2024
DOI: 10.1101/2024.11.19.24317595
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c-Triadem: A constrained, explainable deep learning model to identify novel biomarkers in Alzheimer’s disease

Sherlyn Jemimah,
Ferial Abuhantash,
Aamna AlShehhi

Abstract: Alzheimers disease (AD) is a neurodegenerative disorder that requires early diagnosis for effective management. However, issues with currently available diagnostic biomarkers preclude early diagnosis, necessitating the development of alternative biomarkers and methods, such as blood-based diagnostics. We propose c-Triadem (constrained triple-input Alzheimers disease model), a novel deep neural network to identify potential blood-based biomarkers for AD and predict mild cognitive impairment (MCI) and AD with hi… Show more

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