C-Type Particles in Cells From T-Cell Lymphoma/Leukaemia After 5-7 Days' Culture

Total lipid extracts of peripheral blood cells from patients with chronic leukaemias were analysed for relative values of saturation of the eighteen carbon chain length fatty acids (C 18 FA). The results are expressed as saturation index (C 18 S:C 18 U) of the saturated C 18 FA (stearic acid) over the unsaturated C 18 FA (oleic, linoleic and linolenic acids). The saturation indices of the white blood cells (WBC) and the red blood cells (RBC) in specimens from 14 patients with chronic granulocytic leukaemia (CGL) and 17 patients with chronic lymphocytic leukaemias (CLL) were significantly and consistently lower than control specimens. It is proposed that the relative increase in the unsaturated oleic acid could prove to be a chemical marker of malignancy reflecting a deficient cellular control of the process of stearic acid desaturation. The theoretical implications of the implied increase in membrane fluidity for the cells are discussed.

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Reduction in the stearic to oleic acid ratio in leukaemic cells ? A possible chemical marker of malignancy

Apostolov

Barker

Catovsky

et al. 1985

Blut

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Adult T-cell lymphoma/leukemia in a Caribbean patient: Cytogenetic, immunologic, and ultrastructural findings

Brito‐Babapulle

Matutes

Hegde

et al. 1984

Cancer Genetics and Cytogenetics

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C-Type Particles in Cells From T-Cell Lymphoma/Leukaemia After 5-7 Days' Culture

Cited by 2 publications

References 5 publications

Reduction in the stearic to oleic acid ratio in leukaemic cells ? A possible chemical marker of malignancy

Reduction in the stearic to oleic acid ratio in leukaemic cells ? A possible chemical marker of malignancy

Adult T-cell lymphoma/leukemia in a Caribbean patient: Cytogenetic, immunologic, and ultrastructural findings

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