C-Type virus-like particles specifically localized in langerhans cells and related cells of skin and lymph nodes of patients with mycosis fungoides and Sezary’s syndrome

Loo, E. M. van der; Muijen, G.N.P. van; Vloten, W. A. van; Beens, W.; Scheffer, E.; Meijer, Chris J.L.M.

doi:10.1007/bf02889936

Cited by 82 publications

(4 citation statements)

References 25 publications

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“…MacKie originally launched this hypothesis in 1981 by proposing that CTCL arises from an initial viral infection of epidermal antigen presenting cells [57]. Mackie was inspired by observations of distinctive aggregates of epidermal dendritic cells and T cells in MF patients called Pautrier’s abscesses and also from reports of retrovirus-like particles observed in malignant CTCL T cell cultures [58]. Furthermore, viral antigens have the potential to induce loss of T cell receptor (TCR) diversity, which is a characteristic feature of CTCL [59,60].…”

Section: Infectious Etiologymentioning

confidence: 99%

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

Willerslev-Olsen

Krejsgaard

Lindahl

et al. 2013

Toxins

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In patients with cutaneous T-cell lymphoma (CTCL) bacterial infections constitute a major clinical problem caused by compromised skin barrier and a progressive immunodeficiency. Indeed, the majority of patients with advanced disease die from infections with bacteria, e.g., Staphylococcus aureus. Bacterial toxins such as staphylococcal enterotoxins (SE) have long been suspected to be involved in the pathogenesis in CTCL. Here, we review links between bacterial infections and CTCL with focus on earlier studies addressing a direct role of SE on malignant T cells and recent data indicating novel indirect mechanisms involving SE- and cytokine-driven cross-talk between malignant- and non-malignant T cells.

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Section: Infectious Etiologymentioning

confidence: 99%

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

Willerslev-Olsen

Krejsgaard

Lindahl

et al. 2013

Toxins

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“…In the 1990s, the hypothesis arose that retroviral infection of skin- and lymph node-resident Langerhans cells might be the triggering event in CTCL development [ 22 ]. Retrovirus-like particles were indeed found in these cells [ 23 ], and in 1980, the first publication was released describing the detection and isolation of the causative agent of human adult T-cell leukemia and lymphoma (ATL), HTLV, from MF patient’s PBMCs [ 24 ]. The HTLV etiology hypothesis was further strengthened by well-established significant clinical and histopathological similarities between CTCL and ATL and by several later discoveries.…”

Section: Infectious Agents Involved In the Etiopathogenesis Of Cutane...mentioning

confidence: 99%

The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics

Angelova,

Rommelaere,

Ungerechts

2024

Pathogens

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Cutaneous T-cell lymphoma (CTCL) is a devastating, potentially fatal T-lymphocyte malignancy affecting the skin. Despite all efforts, the etiology of this disease remains unknown. Infectious agents have long been suspected as factors or co-factors in CTCL pathogenesis. This review deals with the panel of bacterial and viral pathogens that have been investigated so far in an attempt to establish a potential link between infection/carriage and CTCL development. A special focus is given to a recently discovered human protoparvovirus, namely the cutavirus (CutaV), which has emerged as a plausible CTCL etiological agent. Available evidence in support of this hypothesis as well as alternative interpretations and uncertainties raised by some conflicting data are discussed. The complexity and multifacetedness of the Parvoviridae family of viruses are illustrated by presenting another protoparvovirus, the rat H-1 parvovirus (H-1PV). H-1PV belongs to the same genus as the CutaV but carries considerable potential for therapeutic applications in cutaneous lymphoma.

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“…Despite isolated case series of familial mycosis fungoides (10) and links to potential HLA alleles (11,12), there is no concrete evidence for genetic predisposition. Additionally, infectious agents such as viruses, viral particles (13)(14)(15), environmental, geographical (16) or occupational exposure (17) have been contemplated to be triggers for the rise of CTCL but a strong link has not been identified.…”

Section: Origin Of Malignant T Cells External Risk Factorsmentioning

confidence: 99%

Update on Biology of Cutaneous T-Cell Lymphoma

2020

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Cutaneous T cell lymphomas (CTCL) comprise of a heterogeneous group of non-Hodgkin lymphomas derived from skin-homing T cells. Variation in clinical presentation and lack of definitive molecular markers make diagnosis especially challenging. The biology of CTCL remains elusive and clear links between genetic aberrations and epigenetic modifications that would result in clonal T cell expansion have not yet been identified. Nevertheless, in recent years, next generation sequencing (NGS) has enabled a much deeper understanding of the genomic landscape of CTCL by uncovering aberrant genetic pathways and epigenetic dysregulations. Additionally, single cell profiling is rapidly advancing our understanding of patients-specific tumor landscape and its interaction with the surrounding microenvironment. These studies have paved the road for future investigations that will explore the functional relevance of genetic alterations in the progression of disease. The ultimate goal of elucidating the pathogenesis of CTCL is to establish effective therapeutic targets with more durable clinical response and treat relapsing and refractory CTCL.

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C-Type virus-like particles specifically localized in langerhans cells and related cells of skin and lymph nodes of patients with mycosis fungoides and Sezary’s syndrome

Cited by 82 publications

References 25 publications

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

Bacterial Toxins Fuel Disease Progression in Cutaneous T-Cell Lymphoma

The Complex Role of Infectious Agents in Human Cutaneous T-Cell Lymphoma Pathogenesis: From Candidate Etiological Factors to Potential Therapeutics

Update on Biology of Cutaneous T-Cell Lymphoma

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