C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1)

Assadollahi, Vahideh; Gholami, Mohammadreza; Zendedel, Abolfazl

doi:10.4149/bll_2015_026

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…It can be clearly seen that cinnamaldehyde was the major components in both Soxhlet and water extract which contributed to 74.14% and 71.69% of total constituents, respectively. This result is parallel with many previous studies [6,7,[12][13][14]. These studies showed that cinnamaldehyde is the major component in C. zeylanicum which contribute from 60% to 80% of total components.…”

Section: Gas Chromatography/ Mass Spectrometry (Gcms) Analysissupporting

confidence: 91%

The Investigation of Cytotoxic Effect of Cinnamomum Zeylanicum Extracts on Human Breast Cancer Cell Line (Mcf-7)

Wahab¹,

Adzmi²

2017

Sci. herit. j.

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Cinnamon is one of the oldest herbal medicine that has been historically known to possess has anticancer property. In this study, the cytotoxicity of the cinnamon extracts towards human breast cancer cell line (MCF-7) was investigated. Cinnamomum zeylanicum was extracted using Soxhlet and water extraction methods, producing 7.06% and 2.54% of yield respectively. The extracts were analysed using Gas Chromatography/ Mass Spectrometry (GCMS) and it was found that cinnamaldehyde is the major constituents which contribute more than 70% of the major constituents. The cytotoxicity of C. zeylanicum extract against MCF-7 was determined through colorimetric MTT assay at 24 and 48 hours of incubation periods. The IC50 values of Soxhlet extract were 58 µg/ml and 140 µg/ml while the IC50 values of water extract were 9 mg/ml and 4.8 mg/ml, at 24 and 48 hours treatment respectively. In conclusion, C. zeylanicum extracts has been confirmed to have cytotoxic effect towards MCF-7 cell line in different concentrations at two different incubation periods.

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Section: Gas Chromatography/ Mass Spectrometry (Gcms) Analysissupporting

confidence: 91%

The Investigation of Cytotoxic Effect of Cinnamomum Zeylanicum Extracts on Human Breast Cancer Cell Line (Mcf-7)

Wahab¹,

Adzmi²

2017

Sci. herit. j.

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“…In another study, 2′-hydroxycinnamicaldehyde, a compound found in cinnamon, was a potent anticancer agent as a result of direct targeting of the Pim-1 kinase [ 244 ]. In addition, cinnamon aqueous extract induced apoptosis in the human myelocytic leukemia cell line (myeloid) [ 245 ].…”

Section: Other Spicesmentioning

confidence: 99%

Spices for Prevention and Treatment of Cancers

et al. 2016

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Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin. The main mechanisms of action include inducing apoptosis, inhibiting proliferation, migration and invasion of tumors, and sensitizing tumors to radiotherapy and chemotherapy. This review summarized recent studies on some spices for prevention and treatment of cancers, and special attention was paid to bioactive components and mechanisms of action.

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“…Cinnamon polyphenols was found to exert neuroprotective effects in glial cells by the regulation of Bcl-2 family members and enhancing the expression of protein coding gene SIRT1 during oxidative stress [10] , [11] . In 2015, Assadollahi et al [12] investigated the effects of Cinnamon zeylanicum aqueous extract on the human myelocytic leukemia cell line. The authors concluded that supplemented Cinnamon zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line.…”

Section: Introductionmentioning

confidence: 99%

Effects of aqueous cinnamon extract on chemically-induced carcinoma of hamster cheek pouch mucosa

Ezzat

AbuElkhair

Mourad

et al. 2017

Biochemistry and Biophysics Reports

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This study aimed to investigate the effects of aqueous cinnamon extract (ACE) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch (HCP) mucosa. Sixty male Syrian hamsters were randomly divided into six equal groups. The hamsters of groups I, II and III received no treatment, DMBA and ACE respectively, for 16 weeks. Groups IV and V were handled as group II and concomitantly treated with ACE for the same period and additionally group V received ACE for other 16 weeks after the stoppage of DMBA application. Group VI hamsters were handled as group III and additionally received DMBA for other 16 weeks after the stoppage of ACE supplementation. Hamsters of each group were euthanized according to the experimental schedule. The buccal pouches were and prepared for H&E stain, PAS reagent, CD3 and PDGF immunohistochemical reactivity. All groups showed dysplastic changes with varying degrees except groups I and III. Deep invasive carcinomas were recorded in 90% of the samples of group II, 60% of group IV, 50% of group V and 40% of group VI. From the previous results, it can be concluded that ACE has the potentiality preventing oral cancer initiation better than inhibiting oral cancer progression.

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C. zeylanicum aqueous extract induced apoptosis in the human myelocytic leukemia cell line (THP-1)

Cited by 8 publications

References 18 publications

The Investigation of Cytotoxic Effect of Cinnamomum Zeylanicum Extracts on Human Breast Cancer Cell Line (Mcf-7)

The Investigation of Cytotoxic Effect of Cinnamomum Zeylanicum Extracts on Human Breast Cancer Cell Line (Mcf-7)

Spices for Prevention and Treatment of Cancers

Effects of aqueous cinnamon extract on chemically-induced carcinoma of hamster cheek pouch mucosa

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