C60 fullerene reduces the level of fluctuations in the force response of muscle gastrocnemius in chronically alcoholized rats

Motuziuk, Oleksandr; Nozdrenko, Dmytro; Prylutska, Svitlana; Bogutska, Kateryna; Mishchenko, I. V.; Абрамчук, Ольга Миколаївна; Khrapatyi, Sergii; Ritter, Uwe; Prylutskyy, Yu. І.

doi:10.1007/s13204-023-02874-7

Cited by 1 publication

(1 citation statement)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is known that biocompatible and bioavailable C 60 fullerene nanoparticles can efficiently capture and inactivate ROSs in in vivo and in vitro systems [13,14]. Recently it was demonstrated that applying water-soluble C 60 fullerenes during chronic alcoholization of rats reduces the level of fluctuations of force muscle response (the so-called "tremor") [15] and protects muscle tissue from damage caused by oxidative stress [16].…”

Section: Introductionmentioning

confidence: 99%

C60 Fullerene Reduces the Level of Liver Damage in Chronic Alcohol Intoxication of Rats

Motuziuk,

Nozdrenko,

Prylutska

et al. 2024

Molecules

Self Cite

View full text Add to dashboard Cite

The liver is the main organ responsible for the metabolism of ethanol, which suffers significantly as a result of tissue damage due to oxidative stress. It is known that C60 fullerenes are able to efficiently capture and inactivate reactive oxygen species in in vivo and in vitro systems. Therefore, the purpose of this study is to determine whether water-soluble C60 fullerene reduces the level of pathological process development in the liver of rats induced by chronic alcohol intoxication for 3, 6, and 9 months, depending on the daily dose (oral administration; 0.5, 1, and 2 mg/kg) of C60 fullerene throughout the experiment. In this context, the morphology of the C60 fullerene nanoparticles in aqueous solution was studied using atomic force microscopy. Such biochemical parameters of experimental animal blood as ALT (alanine aminotransferase), AST (aspartate aminotransferase), GGT (gamma-glutamyl transferase) and ALP (alkaline phosphatase) enzyme activities, CDT (carbohydrate-deficient transferrin) level, values of pro-antioxidant balance indicators (concentrations of H2O2 (hydrogen peroxide) and GSH (reduced glutathione), activities of CAT (catalase), SOD (superoxide dismutase) and GPx (selenium-dependent glutathione peroxidase)), and pathohistological and morphometric features of liver damage were analyzed. The most significant positive change in the studied biochemical parameters (up to 29 ± 2% relative to the control), as markers of liver damage, was recorded at the combined administration of alcohol (40% ethanol in drinking water) and water-soluble C60 fullerenes in the optimal dose of 1 mg/kg, which was confirmed by small histopathological changes in the liver of rats. The obtained results prove the prospective use of C60 fullerenes as powerful antioxidants for the mitigation of pathological conditions of the liver arising under prolonged alcohol intoxication.

show abstract