C677T methylenetetrahydrofolate reductase polymorphism, folate and homocysteine levels and the risk of colorectal cancer

Öksüz, Murat; Ergün, Yılmaz

doi:10.5455/annalsmedres.2020.07.765

Cited by 1 publication

(1 citation statement)

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“…Due to the coexistence of those medical conditions and hyperhomocysteinemia, particularly in older people, Hcy has been named by the medical profession as the cholesterol of the 21st century [ 33 ]. Recently, homocysteine has been investigated during COVID-19, chronic kidney disease, oncogenesis and infertility, emphasizing an interest in this biomarker within the medical and scientific community [ 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

Homocysteine—Potential Novel Diagnostic Indicator of Health and Disease in Horses

Gołyński

Metyk

Ciszewska

et al. 2023

Animals

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Homocysteine is an endogenous, non-protein sulfuric amino acid, an intermediate metabolite formed by the methionine transmethylation reaction. Its elevated serum concentration in humans, hyperhomocysteinemia, is a sensitive indicator and a risk factor for coagulation disorders, cardiovascular diseases and dementia. However, the role of homocysteine in veterinary species has not been unequivocally established. Although some research has been conducted in dogs, cats, cattle and pigs, relatively few studies on homocysteine have been conducted in horses. So far, it has been established in this species that homocysteine has an atherogenic effect, plays a role in early embryo mortality and is responsible for the induction of oxidative stress. These preliminary findings support establishing a reference range in a normal population of horses, including horses in training and merit further investigations into the role of this amino acid in health and disease in this species.

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