C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration

Ebisch, I.M.W.; Heerde, Waander L. van; Thomas, Chris M.G.; Put, Nathalie van der; Wong, Wai Yee; Steegers‐Theunissen, R.P.M.

doi:10.1016/s0015-0282(03)02157-5

Cited by 117 publications

(91 citation statements)

References 18 publications

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“…The MTHFR C677T polymorphism was reported to be associated with male infertility in the German [42], Indian [26,18,17,38], Korean [23], Chinese [19] and Italian populations [41]. In contrast, Stuppia et al [28] and Ebisch et al [21] did not find any statistically significance of C677T variation in infertile men from Italy and the Netherlands. These apparently contradictory data from studies on different populations suggest that the role of C677T insusceptibility to male infertility might depend on ethno geographic factors [19].…”

Section: Discussionmentioning

confidence: 90%

“…A large number of molecular epidemiological studies have been conducted to evaluate the role of the three folate-related enzyme gene (MTHFR, MTR and MTRR) polymorphisms in male infertility [11,13,[15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. However, the association between polymorphism and the risk of male infertility is still controversial.…”

Section: Introductionmentioning

confidence: 99%

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Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

et al. 2015

J Assist Reprod Genet

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Purpose This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folaterelated enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population. Methods The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males. Results We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility. Conclusions There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

et al. 2015

J Assist Reprod Genet

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“…Zinc plays an important role in prostate, epididymal and testicular functions [2]. Zinc has been reported to influence the process of spermatogenesis [3], controls sperm motility [4], stabilizes sperm membrane [5], preserves the ability of sperm nuclear chromatin to undergo decondensation and modulates sperm functions [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus×Bos taurus) bulls

et al. 2006

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-An experiment was conducted on 16 crossbred bulls (about 2 years of age, 316.2 ± 0.77 kg average body weight), divided into groups I, II, III and IV to study the effect of different levels of Zn supplementation from inorganic and organic sources on semen quality. The animals in the first 3 groups were supplemented with 0, 35 and 70 ppm Zn from Zn sulfate, respectively and the animals in-group IV were supplemented with 35 ppm Zn as Zn propionate. Semen collection and evaluation was done in the first month (to assess semen quality at the start of the experiment) and 7th, 8th and 9th month of experimental feeding to evaluate the effect of supplemental Zn on semen attributes. We gave 6 months for Zn feeding, so that 3 sperm cycles of spermatogenesis had passed and the collected semen reflected the complete effect of Zn supplementation. Six ejaculates from each bull were collected and evaluated for semen quantitative (ejaculate volume, sperm concentration and sperm number per ejaculate) and qualitative characteristics (semen pH, mass motility, individual motility, sperm livability percent and abnormal sperm percent, percent intact acrosome, bovine cervical mucus penetration test, hypo-osmotic sperm swelling test) and activity of seminal plasma enzymes i.e., alkaline phosphatase, acid phosphatase, GOT and GPT. Testosterone level in the blood serum of crossbred bulls was also estimated. Mean values of semen quantitative and qualitative characteristics at the start of the experiment were statistically non significant (P > 0.05) in all the crossbred cattle bulls, however, there were statistically significant differences among the bulls of different groups after 6 months of zinc supplementation. Mean ejaculate volume (mL) was 2.37, 4.70, 5.86 and 6.38, respectively in groups I to IV, indicating a statistically significant (P < 0.05) higher semen volume in Zn-supplemented groups as compared to the control group of bulls. Similarly, sperm concentration (million.mL −1 ), live sperm (%) and motility (%) were significantly (P < 0.01) higher in Zn-supplemented groups as compared to the control group. The results of BCMPT and HOSST revealed a significant improvement in sperm functional ability in all the groups supplemented with Zn as compared to the control group. The activity of alkaline and acid phosphatase in seminal plasma was significantly (P < 0.05) higher in the Zn-supplemented groups, whereas GOT and GPT activities in seminal plasma were significantly (P < 0.05) lower in the Zn propionate supplemented group as compared to the control group. Testosterone concentration (ng.mL −1 ) in blood serum was significantly higher in animals of groups III and IV, as compared to control group. It may be concluded that Zn supplementation either in the inorganic or organic form in the diet of crossbred bulls improved the qualitative and quantitative attributes of semen; however, the number of sperm per ejaculate, mass motility and semen fertility test like bovine cervical mucus penetration was significantly higher in bulls gi...

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“…The C677T polymorphism in the gene encoding for methylenetetrahydrofolate reductase, which is one of the key enzymes in the folate metabolism, was studied in 113 fertile and 77 sub-fertile males, and it was shown that the positive effect of folic acid and zinc sulphate supplementation on sperm concentration was seen only in subjects without the T-variant (CC homozygotes) [55]. However, in this study, the polymorphism itself was not a risk factor for male sub-fertility.…”

Section: Fertility and Semen Qualitymentioning

confidence: 61%

Gene-environment interaction and male reproductive function

Axelsson¹,

Bonde²,

Giwercman³

et al. 2010

Asian J Androl

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As genetic factors can hardly explain the changes taking place during short time spans, environmental and lifestyle-related factors have been suggested as the causes of time-related deterioration of male reproductive function. However, considering the strong heterogeneity of male fecundity between and within populations, genetic variants might be important determinants of the individual susceptibility to the adverse effects of environment or lifestyle. Although the possible mechanisms of such interplay in relation to the reproductive system are largely unknown, some recent studies have indicated that specific genotypes may confer a larger risk of male reproductive disorders following certain exposures. This paper presents a critical review of animal and human evidence on how genes may modify environmental effects on male reproductive function. Some examples have been found that support this mechanism, but the number of studies is still limited. This type of interaction studies may improve our understanding of normal physiology and help us to identify the risk factors to male reproductive malfunction. We also shortly discuss other aspects of gene-environment interaction specifically associated with the issue of reproduction, namely environmental and lifestyle factors as the cause of sperm DNA damage. It remains to be investigated to what extent such genetic changes, by natural conception or through the use of assisted reproductive techniques, are transmitted to the next generation, thereby causing increased morbidity in the offspring.

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C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration

Cited by 117 publications

References 18 publications

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

Effect of different levels and sources of zinc supplementation on quantitative and qualitative semen attributes and serum testosterone level in crossbred cattle (Bos indicus×Bos taurus) bulls

Gene-environment interaction and male reproductive function

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