CA 125 secretion by peritoneal mesothelial cells.

Primary Small Intestinal Natural Killer/T Cell Lymphoma Mimicking Tuberculous Peritonitis: Report of a Case and Review of the Literature

“…However, elevated serum CA-125 level has also been reported in nongynecologic tumors and nonmalignant diseases involving the peritoneum, pleura, and pericardium. Zeillemaker et al reported that inflammatory cytokines significantly stimulated the secretion of CA-125 by cultured monolayers of non-activated human mesothelial cells (8). On the basis of the above-mentioned characteristics, elevated levels of CA-125 are indicative of inflammatory, infectious, or neoplastic processes and provide a clue for further investigations.…”

Role of CA125 in the Diagnosis of Acute Appendicitis

“…It is commonly used as a tumor marker for gynecological cancer. However, it secretion from peritoneal epithelium in case of inflammation is demonstrated by in vitro studies (9). According to Basaran (20), the main debate is thatCA125 secretion begins six hours after the onset of inflammation.…”

“…It is mainly used in the diagnosis and post-op follow-up of gynecological tumors. In males, the main source of CA125 is liver cirrhosis (9). Recently, secretion of CA125 from peritoneal cells due to inflammatory stimulus has been shown.…”

A Rare Cause of Antigen Cancer Elevation 125 (CA 125): A Case of Uterine Adenomyosis

“…2 While the diagnosis of adenomyosis is histopathologic, transvaginal ultrasound and MRI can be strongly suggestive. The antigen cancer 125 (CA 125) is currently, apart the ovarian's epithelium cancer, used in the diagnosis of deep endometriosis, and does not appear as a determining element in the diagnosis of adenomyosis.…”