Ca2+ accumulations in dendrites of neocortical pyramidal neurons: An apical band and evidence for two functional compartments

Yuste, Rafael; Gutnick, Michael J.; Saar, Drorit; Delaney, Kerry R.; Tank, David W.

doi:10.1016/0896-6273(94)90457-x

Cited by 282 publications

(192 citation statements)

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“…On the bases of the experimental findings that focal application of Na ϩ (TTX), or Ca 2ϩ channel (Cd 2ϩ or Ni 2ϩ ) blockers onto apical dendrites attenuates distally evoked synaptic potentials, inward cationic currents via Na ϩ , as well as low-and high-voltage-activated Ca 2ϩ channels have been implicated in "amplifying" the propagating distal synaptic signals en route to the soma (Markram and Sakmann 1994;Yuste et al 1994; Magee and Johnston 1995b;Schwindt and Crill 1995;Stuart and Sakmann 1995; Lipowsky et al 1996;Seamans et al 1997) (Figure 3). …”

Section: Apical Dendritic Compartment Of Deep Layer Pyramidal Corticamentioning

confidence: 99%

“…Combined pharmacological, electrophysiological, and Ca 2ϩ imaging studies have shown that high-and lowvoltage-activated Ca 2ϩ channels distribute widely, but heterogeneously, throughout the soma and the apical dendrites of pyramidal neurons (Brown et al 1993; Kim and Connors 1993;Mills et al 1994;Yuste et al 1994;Markram et al 1995;Schiller et al 1995;Miura et al 1997). These soma-dendritic Ca 2ϩ channels include T-, L-, P/Q, and N-types (Hillman et al 1991;Ye and Akaike 1993;Markram and Sakmann 1994; Johnston 1995a, 1995b; Kavalali et al 1997a).…”

Section: Apical Dendritic Compartment Of Deep Layer Pyramidal Corticamentioning

confidence: 99%

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Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

Yang

Seamans

Gorelova

1999

Neuropsychopharmacology

164

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This review covers some recent findings of the electrophysiological mechanisms through which mesocortical dopamine modulates prefrontal cortical neurons. Dopamine has been shown to modulate several ionic conductances located along the soma-dendritic axis of prefrontal cortical pyramidal neurons. These ionic currents include high-voltage-activated calcium currents and slowly inactivating NaReceived May 12, 1998; revised May 27, 1998; accepted May 29, 1998. 162 C.R. Yang et al. N EUROPSYCHOPHARMACOLOGY 1999 -VOL . 21 , NO Schizophrenia strikes one in one hundred people worldwide, regardless of cultural or racial origins. As the illness progresses and if it remains unattended, patients are frequently trapped in psychological, social, and economic devastation (Gottesman 1991;Jablensky 1995). Currently, our incomplete understanding of the neurobiological bases of schizophrenia suggests that defects in the genetic controls of brain development in such limbic regions (including temporal lobe structures such as hippocampus and the amygdala) as well as the prefrontal cortex (PFC) lead to cell loss or deformation, cytoarchitectural disorganization, and abnormal innervation in these brain regions (Roberts and Bruton 1990;Stevens 1992; Bogerts 1993;Shapiro 1993; Akbarian et al. 1993 Akbarian et al. , 1996Ross and Pearlson 1996;Weinberger 1996; Karayiorgou and Gogos 1997; Lewis 1997;Selemon et al. 1995Selemon et al. , 1998.Some results from recent imaging studies of brains from living schizophrenics have suggested that there are defective functional communications between the interconnected cortical (PFC and cingulate cortex) and limbic subcortical structures (thalamus, striatum, and temporal lobe limbic structures)(see reviews of Liddle 1996; Pfefferbaum and Marsh 1995; Andreasen 1997; Heckers et al. 1998). Findings from these studies suggest that in schizophrenics, abnormal recruitment of several interconnected cortical and subcortical structures may underlie such symptom clusters as psychomotor poverty, thought disorganization, and reality distortion (Liddle et al. 1992; Liddle 1996; Fletcher 1998; Heckers et al. 1998).As noted in Figure 1, the PFC receives converging limbic, association cortical, and mesocortical dopamine inputs. These inputs interact in the PFC and are involved functionally in high-level cognitive processes (Fuster 1995). Among the many brain regions that PFC output innervates, two important subcortical regions are emphasized in this review. These are the nucleus accumbens (where mesoaccumbens dopamine neurons terminate) and the ventral tegmental area (VTA, where the midbrain dopamine neurons reside) Groenewegen et al. 1990; Berendse et al. 1992a Berendse et al. , 1992bSesack and Pickel 1992;Gorelova and Yang 1997b). Several of the interconnected limbic, cortical, and subcortical structures known to be affected in schizophrenia are targets of the ascending midbrain dopamine systems that normally provide functional modulation of neurotransmission (Björklund and Lindvall 1984;Mogenson et ...

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Section: Apical Dendritic Compartment Of Deep Layer Pyramidal Corticamentioning

confidence: 99%

Section: Apical Dendritic Compartment Of Deep Layer Pyramidal Corticamentioning

confidence: 99%

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

Yang

Seamans

Gorelova

1999

Neuropsychopharmacology

164

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“…1 A, B, 4B). We never detected fast transient TTX-sensitive Na ϩ currents in voltage clamp even when all other voltage-activated currents were blocked to make the neuron electrotonically more compact (data not shown) (Yuste et al, 1994;Kloppenburg et al, 2000). Voltage steps to between Ϫ55 and Ϫ25 mV from a holding potential of Ϫ80 mV revealed a sustained inward current identified as a voltage-activated Ca 2ϩ current (Fig.…”

Section: Type II Lnsmentioning

confidence: 99%

Calcium Current Diversity in Physiologically Different Local Interneuron Types of the Antennal Lobe

Husch¹,

Paehler²,

Fusca³

et al. 2009

J. Neurosci.

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Behavioral and physiological studies show that neuronal interactions among the glomeruli in the insect antennal lobe (AL) take place during the processing of odor information. These interactions are mediated by a complex network of inhibitory and excitatory local interneurons (LNs) that restructure the olfactory representation in the AL, thereby regulating the tuning profile of projection neurons. In Periplaneta americana, we characterized two LN types with distinctive physiological properties: (1) type I LNs that generated Na ϩ -driven action potentials on odor stimulation and exhibited GABA-like immunoreactivity (GLIR) and (2) type II LNs, in which odor stimulation evoked depolarizations, but no Na ϩ -driven action potentials (APs). Type II LNs did not express voltage-dependent transient Na ϩ currents and accordingly would not trigger transmitter release by Na ϩ -driven APs. Ninety percent of type II LNs did not exhibit GLIR. The distinct intrinsic firing properties were reflected in functional parameters of their voltage-activated Ca 2ϩ currents (I Ca ). Consistent with graded synaptic release, we found a shift in the voltage for half-maximal activation of I Ca to more hyperpolarized membrane potentials in the type II LNs. These marked physiological differences between the two LN types imply consequences for their computational capacity, synaptic output kinetics, and thus their function in the olfactory circuit.

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“…Spatial factors may affect the gain increase and its modulation by G sAHP . Na ϩ and Ca 2ϩ spikes generated in apical dendrites (Kim and Connors, 1993;Reuveni et al, 1993;Yuste et al, 1994;Schiller et al, 1997;Stuart et al, 1997;Schwindt and Crill, 1999;Larkum et al, 1999) might cause noise to increase gain in some pyramidal neurons. Noisy current injected into the distal apical dendrite of layer 5 pyramidal cells increases gain for 4 stimulus fluctuation to fire, and its gain increases with noise amplitude.…”

Section: Mechanisms Of Noise Effectsmentioning

confidence: 99%

Diversity of Gain Modulation by Noise in Neocortical Neurons: Regulation by the Slow Afterhyperpolarization Conductance

Higgs¹,

Slee²,

Spain³

2006

J. Neurosci.

118

154

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Neuronal firing is known to depend on the variance of synaptic input as well as the mean input current. Several studies suggest that input variance, or "noise," has a divisive effect, reducing the slope or gain of the firing frequency-current ( f-I) relationship. We measured the effects of current noise on f-I relationships in pyramidal neurons and fast-spiking (FS) interneurons in slices of rat sensorimotor cortex. In most pyramidal neurons, noise had a multiplicative effect on the steady-state f-I relationship, increasing gain. In contrast, noise reduced gain in FS interneurons. Gain enhancement in pyramidal neurons increased with stimulus duration and was correlated with the amplitude of the slow afterhyperpolarization (sAHP), a major mechanism of spike-frequency adaptation. The 5-HT 2 receptor agonist ␣-methyl-5-HT reduced the sAHP and eliminated gain increases, whereas augmenting the sAHP conductance by spike-triggered dynamic-current clamp enhanced the gain increase. These results indicate that the effects of noise differ fundamentally between classes of neocortical neurons, depending on specific biophysical properties including the sAHP conductance. Thus, noise from background synaptic input may enhance network excitability by increasing gain in pyramidal neurons with large sAHPs and reducing gain in inhibitory FS interneurons.

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Ca2+ accumulations in dendrites of neocortical pyramidal neurons: An apical band and evidence for two functional compartments

Cited by 282 publications

References 50 publications

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

Developing a Neuronal Model for the Pathophysiology of Schizophrenia Based on the Nature of Electrophysiological Actions of Dopamine in the Prefrontal Cortex

Calcium Current Diversity in Physiologically Different Local Interneuron Types of the Antennal Lobe

Diversity of Gain Modulation by Noise in Neocortical Neurons: Regulation by the Slow Afterhyperpolarization Conductance

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