Ca2+-dependent K+ channels are targets for bradykinin B1 receptor ligands and for lipopolysaccharide in the rat aorta

Farias, Nelson Carvalho; Feres, Teresa; Paiva, Antonio C.M.; Paiva, Therezinha B.

doi:10.1016/j.ejphar.2005.09.047

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Cited by 6 publications

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“…In vascular smooth muscle, large conductance Ca 2+ ‐activated K + (BK Ca ) channel opening is involved in the B 1 ‐mediated relaxation . In the present study, the relaxations to kallidin were practically abolished in 80 mM KPSS‐precontracted strips.…”

Section: Discussionsupporting

confidence: 44%

Neuronal and non-neuronal bradykinin receptors are involved in the contraction and/or relaxation to the pig bladder neck smooth muscle

Ribeiro

Fernandes

Martínez

et al. 2013

Neurourol. Urodynam.

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These results suggest that BK produces contraction of pig bladder neck via smooth muscle B2 receptors coupled to extracellular Ca(2+) entry via VOC and non-VOC channels with a minor role for intracellular Ca(2+) mobilization. Facilitatory neuronal B2 receptors modulating NANC inhibitory neurotransmission and urothelial B1 receptors producing relaxation via the COX-1 pathway and BKCa channel opening are also demonstrated. Neurourol. Urodynam. 33:558-565, 2014. © 2013 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 44%