Cabazitaxel-loaded MPEG-PCL copolymeric nanoparticles for enhanced colorectal cancer therapy

Chen, Yu; Lu, Yi; Hu, Danrong; Peng, Jinrong; Xiao, Yao; Hao, Ying; Pan, Meng; Yuan, Liping; Qian, Zhiyong

doi:10.1016/j.apmt.2021.101210

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…Improved bioavailability and biocompatibility were reported. Enhanced drug loading capacity, anti-tumor effect and stability were observed [ 136 ]. PCL nanoparticles were employed for the simultaneous delivery of two drugs such as Paclitaxel and IR780, for the treatment of ovarian cancer.…”

Section: Synthetic Biopolymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Sreena

Nathanael

2023

Materials

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Biopolymers are polymers obtained from either renewable or non-renewable sources and are the most suitable candidate for tailor-made nanoparticles owing to their biocompatibility, biodegradability, low toxicity and immunogenicity. Biopolymeric nanoparticles (BPn) can be classified as natural (polysaccharide and protein based) and synthetic on the basis of their origin. They have been gaining wide interest in biomedical applications such as tissue engineering, drug delivery, imaging and cancer therapy. BPn can be synthesized by various fabrication strategies such as emulsification, ionic gelation, nanoprecipitation, electrospray drying and so on. The main aim of the review is to understand the use of nanoparticles obtained from biodegradable biopolymers for various biomedical applications. There are very few reviews highlighting biopolymeric nanoparticles employed for medical applications; this review is an attempt to explore the possibilities of using these materials for various biomedical applications. This review highlights protein based (albumin, gelatin, collagen, silk fibroin); polysaccharide based (chitosan, starch, alginate, dextran) and synthetic (Poly lactic acid, Poly vinyl alcohol, Poly caprolactone) BPn that has recently been used in many applications. The fabrication strategies of different BPn are also being highlighted. The future perspective and the challenges faced in employing biopolymeric nanoparticles are also reviewed.

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Section: Synthetic Biopolymeric Nanoparticlesmentioning

confidence: 99%

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Sreena

Nathanael

2023

Materials

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Recent Advancements of Supramolecules in the Evolution of Cardiovascular Drugs

Kiremit¹,

Tekinay²

2022

Pharmaceutical Applications of Supramolecules

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Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations

Upaganlawar¹,

Polshettiwar

Raut³

et al. 2022

CDM

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Background: Global cancer statistics defines the severity of disease even after significant research worldwide. Problem: Failure of the currently available treatment approaches including surgery, radiation therapy and traditional chemotherapy. Aim: The aim of this review is to discuss the role of phytochemical based nano-formulations for treatment of cancer. Discussion: In the past few decades, phytochemicals have gained popularity for acting as a potential anticancer treatment with low systemic toxicity, especially in terms of cell cycle control and cancer cell killing. Natural resources, with their immense structural variety, serve as a vital source of fresh, therapeutically useful new chemical entities for the treatment of cancer. Vinca alkaloids (VCR), vinblastine, vindesine, vinorelbine, taxanes (PTX), podophyllotoxin and its derivatives (etoposide (ETP), teniposide, camptothecin (CPT) and its derivatives (topotecan, irinotecan), anthracyclines (doxorubicin, daunorubicin, epirubicin, idarubicin, as natural products or their derivatives account for half of all anti-cancer drugs approved worldwide, and they have been developed utilising the knowledge learned from the natural small molecules or macromolecules. Trabectedin, an epothilone derivative, ixabepilone, and temsirolimus, three new anti-cancer medications launched in 2007 were derived from microbial origins. Current therapy regimens require selective drug targeting to enhance efficacy against cancer cells while normal cells remain unharmed. Modified medications and systems for drug delivery based on nanotechnology are in the process of being explored and launched in the industry for enhanced therapy and management of cancer, along with promising outcomes. Many obstacles related to cancer cell drug delivery can be overcome by using nano-particulate drug carriers, including enhancing the stability and solubility of the drug, prolonging half-lives of the drug in the blood, decreasing side effects to undesired organs, and increasing medication concentration at the desired site. The scientific initiatives and studies concerning the use of nanotechnology for some selective compounds derived from plants are discussed in this review article. Conclusion: The present review highlights the phytochemical-based nanoformulations and its strategies in the development of novel systems of drug delivery such as nano-liposomes, functionalized nanoparticles (NPs), and polymer nano-conjugates, SNEDDS (Self nano emulsifying drug delivery system) as this review paper depicts, as well as their rewards over conventional systems of drug delivery, as evidenced by improved biological activity depicted in their in vitro and in vivo anticancer assays.

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Cabazitaxel-loaded MPEG-PCL copolymeric nanoparticles for enhanced colorectal cancer therapy

Cited by 5 publications

References 46 publications

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Biodegradable Biopolymeric Nanoparticles for Biomedical Applications-Challenges and Future Outlook

Recent Advancements of Supramolecules in the Evolution of Cardiovascular Drugs

Effective Cancer Management: Inimitable Role of Phytochemical Based Nano- Formulations

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