Cabergoline treatment in men with psychogenic erectile dysfunction: a randomized, double-blind, placebo-controlled study

Nickel, Marius; Moleda, D; Loew, Thomas H.; Rother, Wolfhardt K.; Gil, Francisco

doi:10.1038/sj.ijir.3901483

Cited by 19 publications

(17 citation statements)

References 11 publications

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“…The dopamine agonist cabergoline has been shown to augment plasma prolactin levels and was studied for its utility in treating psychogenic erectile dysfunction (ED) (50, 51). In one study, patients were treated with cabergoline 0.5 mg for 4 months in a randomized, double-blinded, placebo-controlled trial with 25 patients in the active arm and 25 in the placebo arm.…”

Section: Management Strategies (Figure 2)mentioning

confidence: 99%

Delayed orgasm and anorgasmia

Jenkins

Mulhall

2015

Fertility and Sterility

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Delayed orgasm/anorgasmia defined as the persistent or recurrent difficulty, delay in, or absence of attaining orgasm after sufficient sexual stimulation, which causes personal distress. Delayed orgasm and anorgasmia are associated with significant sexual dissatisfaction. A focused medical history can shed light on the potential etiologies; which include: medications, penile sensation loss, endocrinopathies, penile hyperstimulation and psychological etiologies, amongst others. Unfortunately, there are no excellent pharmacotherapies for delayed orgasm/anorgasmia, and treatment revolves largely around addressing potential causative factors and psychotherapy.

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Section: Management Strategies (Figure 2)mentioning

confidence: 99%

Delayed orgasm and anorgasmia

Jenkins

Mulhall

2015

Fertility and Sterility

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“…Dopamine agonists-Dopamine agonists have been reported to improve sexual function [159] on the basis of research showing that sexual motivation is modulated by a number of central nervous system neurotransmitter and receptor changes induced, in part, by the action of sex steroids and by the central neurotransmitter dopamine. Dopamine neurotransmitter systems may play a critical intermediary role in the central regulation of sexual arousal and excitation, mood, and incentive-related sexual behavior, particularly in the motivational responses to conditioned external stimuli [160][161][162][163][164].…”

Section: 44mentioning

confidence: 99%

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

2007

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Objectives-Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology. Methods-A literature review was performed utilizing the US National Library of Medicine's PubMed database.Results-On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgendependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction. Conclusions-The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns.

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“…Other emerging treatments include the use of pelvis floor exercise [86] and the novel use of agents such as cabergoline [87] for psychogenic ED.…”

Section: Future Developmentsmentioning

confidence: 99%

Erectile Dysfunction

Wylie¹

2008

Advances in Psychosomatic Medicine

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Erectile dysfunction is a common problem affecting sexual function in men. Approximately one in 10 men over the age of 40 is affected by this condition and the incidence is age related. Erectile dysfunction is a sentinel marker for several reversible conditions including peripheral and coronary vascular disease, hypertension and diabetes mellitus. Endothelial dysfunction is a common factor between the disease states. Concurrent conditions such as depression, late-onset hypogonadism, Peyronie's disease and lower urinary tract symptoms may significantly worsen erectile function, other sexual and relationship issues and penis dysmorphophobia. A focused physical examination and baseline laboratory investigations are mandatory. Management consists of initiating modifiable lifestyle changes, psychological and psychosexual/couples interventions and pharmacological and other interventions. In combination and with treatment of concurrent comorbid states, these interventions will often bring about successful resolution of symptoms and avoid the need for surgical interventions.

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Cabergoline treatment in men with psychogenic erectile dysfunction: a randomized, double-blind, placebo-controlled study

Cited by 19 publications

References 11 publications

Delayed orgasm and anorgasmia

Delayed orgasm and anorgasmia

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

Erectile Dysfunction

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