Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic stable heart failure patients

Castillo-Martı́nez, Lilia; Colin-Ramírez, Eloisa; Orea-Tejeda, Arturo; Islas, Dulce Gabriela González; Rodríguez-García, Wendy Daniella; Díaz, Cira Santillán; Rodríguez, Alexis; Durán, Marisela Vázquez; Davies, Candace Keirns

doi:10.1016/j.nut.2011.11.024

Cited by 52 publications

(35 citation statements)

References 23 publications

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“…ed that the cachectic state is an independent risk factor for mortality in different chronic diseases including cancer [18], chronic heart failure [5], chronic obstructive pulmonary disease [32] or rheumatoid arthritis [20]. In summary, results of our study document the presence of ZAG in the brain of Krabbe's disease patients and suggest that this protein penetrates the brain through the blood-brain barrier.…”

supporting

confidence: 52%

Crosstalk in human brain between globoid cell leucodystrophy and zinc-alpha-2-glycoprotein (ZAG), a biomarker of lipid catabolism

Maślińska

Laure‐Kamionowska²,

Maśliński³

2013

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A b s t r a c t Zinc-alpha-2-glycoprotein (ZAG) is a protein identified as a lipid-mobilizing factor participating in a lipid catabolism. In spite of intensive studies conducted during last five decades, the role of this protein in processes of neurodegeneration remains unclear. The aim of our study was to examine the presence of ZAG protein in the brain of patients with Krabbe's disease, which is considered as a psychosine lipidosis caused by a mutation of a known gene. We found intracellular and extracellular localization of ZAG in the brain of Krabbe's disease patients but in the brain of control age-matched patients, ZAG was not detected. Distribution of ZAG in the brain suggests that the influx of ZAG into the brain involved a blood-brain barrier mechanism and adenoreceptors localized on astrocytes and some neurons.

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supporting

confidence: 52%

Crosstalk in human brain between globoid cell leucodystrophy and zinc-alpha-2-glycoprotein (ZAG), a biomarker of lipid catabolism

Maślińska

Laure‐Kamionowska²,

Maśliński³

2013

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“…Nowadays, BIVA is a widely used technique in medicine as a valid tool in the assessment of different physiological states and clinical conditions in which euhydration is frequently altered, such as renal disease [41], critically ill patients [42], pulmonary disease [43], heart failure [44], gastrointestinal disease [45], and pregnancy and postpartum [46]. Its properties are especially interesting for hydration assessments in both the training process and competitive sporting events [16, 47].…”

Section: Discussionmentioning

confidence: 99%

Bioelectrical impedance vector analysis (BIVA) for measuring the hydration status in young elite synchronized swimmers

et al. 2017

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PurposeThe assessment of body hydration is a complex process, and no measurement is valid for all situations. Bioelectrical impedance vector analysis (BIVA) has emerged as a relatively novel technique for assessing hydration status in sports. We applied BIVA a) to determine hydration changes evoked by an intense synchronized swimming (SS) training session; b) to characterize the sample of young elite swimmers in relation with a nonathletic reference population; and c) to generate its 50%, 75% and 95% percentiles of the bioelectrical variables.MethodsForty-nine elite SS female swimmers of two age categories, comen (Co: 13.9 ± 0.9 years, n = 34) and junior (Jr: 16.3 ± 0.6 years, n = 15), performed a long, high intensity training session. Body mass (BM) and bioelectrical variables (R, resistance; Xc, reactance; PA, phase angle; and Z, impedance module) were assessed pre- and post-training. BIVA was used to characterize 1) the distribution pattern of the bioelectrical vector (BIA vector) for both age groups, and 2) pre- to post-training BIA vector migration. Bioelectrical variables were also correlated with BM change values.ResultsMost swimmers were mostly located outside the 75% and some beyond the 95% percentile of the bioelectrical tolerance ellipses of the general population. The BIA vector showed statistically significant differences in both Co (T2 = 134.7, p = 0.0001) and Jr (T2 = 126.2, p < 0.001). Both groups were also bioelectrically different (T2 = 17.6, p < 0.001). After the training session, a decrease in BM (p = 0.0001) and an increase in BIA variables (p = 0.01) was observed. BIVA also showed a significant pre-post vector migration both in Co (T2 = 82.1; p < 0.001) and Jr (T2 = 41.8; p < 0.001). No correlations were observed between BM changes and bioelectrical variables.ConclusionsBIVA showed specific bioelectrical characteristics in young elite SS athletes. Considering the decrease in BM and the migration of the BIA vector, we conclude that the homeostatic hydration status of these young elite female swimmers was affected by the execution of intense training sessions. From a methodological perspective, BIVA appears to be sensitive enough to detect subtle hydration changes, but further research is needed to ensure its validity and reliability. Moreover, these findings highlight the importance of ensuring adequate fluid intake during training in young SS athletes.

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“…Hypoalbuminemia is an important medical issue associated with malnutrition and cardiac cachexia [25], eventually leading to poor prognosis. The prevalence of hypoalbuminemia was reported to be increased with age in patients with CHF [26].…”

Section: The Impact Of Kidney Dysfunction On Hypoalbuminemia In Patiementioning

confidence: 99%

Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure

et al. 2015

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Cachexia assessed by bioimpedance vector analysis as a prognostic indicator in chronic stable heart failure patients

Cited by 52 publications

References 23 publications

Crosstalk in human brain between globoid cell leucodystrophy and zinc-alpha-2-glycoprotein (ZAG), a biomarker of lipid catabolism

Crosstalk in human brain between globoid cell leucodystrophy and zinc-alpha-2-glycoprotein (ZAG), a biomarker of lipid catabolism

Bioelectrical impedance vector analysis (BIVA) for measuring the hydration status in young elite synchronized swimmers

Comorbid renal tubular damage and hypoalbuminemia exacerbate cardiac prognosis in patients with chronic heart failure

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