CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials

Ferreira, Ana M.; Vikulina, Anna S.; Volodkin, Dmitry

doi:10.1016/j.jconrel.2020.08.061

Cited by 83 publications

(44 citation statements)

References 134 publications

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“…The loading and unloading of bioagents on modified biomolecules can be done to achieve better scaffolds for controlled and programmed drug and protein delivery. Vaterite offers enormous possibilities for the encapsulation and release of bioactives of different nature that may include not only large biomacromolecules but even small anticancer drugs, lipids, antimicrobials and other relevant molecules [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. There is limited study on this aspect where vaterite is formed on the solid surface of biomaterials, and we believe this relatively unexplored field will pave-way for the future fabrication of efficient biomaterials with tailor-made properties and excellent performance for various bio-applications.…”

Section: Discussionmentioning

confidence: 99%

Modification of Surfaces with Vaterite CaCO3 Particles

et al. 2022

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Former studies have demonstrated a strong interest toward the crystallization of CaCO3 polymorphs in solution. Nowadays, CaCO3 crystallization on solid surfaces is extensively being studied using biomolecules as substrates for the control of the growth aiming at various applications of CaCO3. Calcium carbonate exists in an amorphous state, as three anhydrous polymorphs (aragonite, calcite and vaterite), and as two hydrated polymorphs (monohydrocalcite and ikaite). The vaterite polymorph is considered as one of the most attractive forms due to its large surface area, biocompatibility, mesoporous nature, and other features. Based on physical or chemical immobilization approaches, vaterite can be grown directly on solid surfaces using various (bio)molecules, including synthetic polymers, biomacromolecules such as proteins and peptides, carbohydrates, fibers, extracellular matrix components, and even biological cells such as bacteria. Herein, the progress on the modification of solid surfaces by vaterite CaCO3 crystals is reviewed, focusing on main findings and the mechanism of vaterite growth initiated by various substances mentioned above, as well as the discussion of the applications of such modified surfaces.

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Section: Discussionmentioning

confidence: 99%

Modification of Surfaces with Vaterite CaCO3 Particles

et al. 2022

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“…The encapsulation of large sensitive macromolecules is possible due to the ability to form and load vaterite at close-to-physiological conditions [124], thereby maintaining the bioactivity of such materials [88]. Vaterite CaCO 3 also proved itself a diverse material as both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO 3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

“…both a stand-alone drug delivery vehicle [131][132][133][134] and as a material for surface coatings [123] for functional use as an antimicrobial carrier, for instance [135,136]. However, there can be an issue with the aggregation of vaterite CaCO3 crystals, making it difficult to form monodisperse templates without the need of additives, such as polypeptides [137].…”

Section: Capsules Formed From Porous Templatesmentioning

confidence: 99%

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

Vikulina

Campbell

2021

Nanomaterials

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One of the undeniable trends in modern bioengineering and nanotechnology is the use of various biomolecules, primarily of a polymeric nature, for the design and formulation of novel functional materials for controlled and targeted drug delivery, bioimaging and theranostics, tissue engineering, and other bioapplications. Biocompatibility, biodegradability, the possibility of replicating natural cellular microenvironments, and the minimal toxicity typical of biogenic polymers are features that have secured a growing interest in them as the building blocks for biomaterials of the fourth generation. Many recent studies showed the promise of the hard-templating approach for the fabrication of nano- and microparticles utilizing biopolymers. This review covers these studies, bringing together up-to-date knowledge on biopolymer-based multilayer capsules and beads, critically assessing the progress made in this field of research, and outlining the current challenges and perspectives of these architectures. According to the classification of the templates, the review sequentially considers biopolymer structures templated on non-porous particles, porous particles, and crystal drugs. Opportunities for the functionalization of biopolymer-based capsules to tailor them toward specific bioapplications is highlighted in a separate section.

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“…20,21 The pHresponsiveness enables nano-scaled CaCO 3 to become an ideal drug delivery system as well as a theranostic platform responding to tumor microenvironment. 20,[22][23][24] By virtue of the principle of enhancing HIFU by gasdependent cavitation, CaCO 3 also shows potential for HIFU enhancement due to its CO 2 generation capability.…”

Section: Introductionmentioning

confidence: 99%

pH-Responsive Nanoparticles for Enhanced Antitumor Activity by High-Intensity Focused Ultrasound Therapy Combined with Sonodynamic Therapy

Gao¹,

Wang²,

Tan³

et al. 2022

IJN

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Background Therapeutic ultrasound (US) has been extensively explored for its inherent high tissue-penetrating capability and on-demand irradiation without radioactive damage. Although high-intensity focused ultrasound (HIFU) is evolved as such an outstanding US-based approach, its insufficient therapeutic effect and the high-intensity induced potential damage to surrounding normal tissues hindered its development towards practical application. As opposed to high intensity ultrasound, sonodynamic therapy (SDT) is a low intensity US-based method which exhibits certain therapeutic effects against cancer via sonosensitizers-generated reactive oxygen species (ROS) overproduction. Methods Hematoporphyrin monomethyl ether (HMME) loaded CaCO 3 nanoparticles (designated as Ca@H) were synthesized by a gas diffusion method. The pH-responsive performance, in vitro SDT, ex vivo HIFU therapy (HIFUT), photoacoustic (PA) imaging and in vivo HIFUT combined with SDT were investigated thoroughly. Results Ca@H NPs gradually decomposed in acid tumor microenvironment, produced CO 2 and released HMME. Both CO 2 and HMME enhanced photoacoustic (PA) imaging. The generated CO 2 bubbles also enhanced HIFUT by inducing an enlarged ablation area. The tumor ablation efficiency (61.04%) was significantly improved with a combination of HIFU therapy and SDT. Conclusion pH-responsive Ca@H NPs have been successfully constructed for PA imaging-guided/monitored HIFUT combined with SDT. With the assistance of pH-responsive Ca@H NPs, the combination of these two US-based therapies is expected to play a role in the treatment of non-invasive tumor in the future.

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CaCO3 crystals as versatile carriers for controlled delivery of antimicrobials

Cited by 83 publications

References 134 publications

Modification of Surfaces with Vaterite CaCO3 Particles

Modification of Surfaces with Vaterite CaCO3 Particles

Biopolymer-Based Multilayer Capsules and Beads Made via Templating: Advantages, Hurdles and Perspectives

pH-Responsive Nanoparticles for Enhanced Antitumor Activity by High-Intensity Focused Ultrasound Therapy Combined with Sonodynamic Therapy

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