Cadherin-6 gene regulatory patterns in the postnatal mouse brain

Inoue, Yukiko; Asami, Junko; Inoue, Tohru

doi:10.1016/j.mcn.2008.05.020

Cited by 25 publications

(23 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is proposed to both scavenge ROS and contribute to the regeneration of other antioxidants such as vitamin E, ascorbate and coenzyme Q 10 . In one study, the antioxidant effect of LA in patients with chronic wounds receiving hyperbaric oxygen (HBO) therapy was assessed in 20 patients [31] .…”

Section: Vitamin Dmentioning

confidence: 99%

“…Inflammatory cells produce ROS as a defense against invading pathogens. The respiratory burst produced by neutrophils and other leukocytes such as macrophages and monocytes creates large quantities of ROS mainly through the enzyme complex NADPH oxidase [10] . These ROS include the superoxide anion and the dismutated, nonradical product hydrogen peroxide.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

220

144

View full text Add to dashboard Cite

Many facets of wound healing under redox control require a delicate balance between oxidative stress and antioxidants. While the normal physiology of wound healing depends on low levels of reactive oxygen species and oxidative stress, an overexposure to oxidative stress leads to impaired wound healing. Antioxidants are postulated to help control wound oxidative stress and thereby accelerate wound healing. Many antioxidants are available over the counter or by prescription, but only one, Medihoney®, has been specifically FDA approved for wound healing. Here we review the existing evidence for the use of antioxidants for wound healing, with a review of the pertinent animal and clinical studies. Natural products and naturally derived antioxidants are becoming more popular, and we specifically review the evidence for the use of naturally derived antioxidants in wound healing. Antioxidant therapy for wound healing is promising, but only few animal studies and even fewer clinical studies are available. Because only few products have undergone FDA approval, the consumer is advised to scrutinize them for purity and contaminants prior to use, and this may require direct contact with the companies that sell them. As a field of science, the use of antioxidants for wound healing is in its infancy, and future studies will better elucidate the role of antioxidants in wound healing.

show abstract

Section: Vitamin Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Fitzmaurice

Sivamani

Isseroff

2011

Skin Pharmacol Physiol

220

144

View full text Add to dashboard Cite

show abstract

“…Notch-dependent, DAPT-sensitive regulation of Cdh6 mRNA and protein was observed in mK4 cells ( Figure S3B, S3C, S5B, and S5C). To map the functional kidney-specific Cdh6 enhancer in vivo, we examined transgenic embryos harboring overlapping, LacZ-containing bacterial artificial chromosomes (BAC) fragments covering the Cdh6 locus (Inoue et al, 2008a;Inoue et al, 2008bInoue et al, , 2009. LacZ expression was detected in the developing kidney ( Figure 5D) only when the BAC contained the enhancer identified by Notch SpDamID (segment "K", Figure 5D) but not when it was absent.…”

Section: Spdamid Identifies Notch-dependent Enhancers At the Nrarp Anmentioning

confidence: 99%

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

Hass¹,

Liow²,

Rothenberg³

et al. 2016

Molecular Cell

Self Cite

View full text Add to dashboard Cite

SUMMARYWe developed Split DamID (SpDamID), a protein complementation version of DamID, to mark genomic DNA bound in vivo by interacting or juxtapositioned transcription factors. Inactive halves of DAM (DNA Adenine Methyltransferase) were fused to protein pairs to be queried Interaction or proximity enabled DAM reconstitution and methylation of adenine in GATC.Inducible SpDamID was used to analyze Notch-mediated transcriptional activation. We demonstrate that Notch complexes label RBP sites broadly across the genome, and show that a subset of these complexes that recruit MAML and p300 undergo changes in chromatin accessibility in response to Notch signaling. SpDamID differentiates between monomeric and dimeric binding thereby allowing for identification of half-site motifs used by Notch dimers. Motif enrichment of Notch enhancers coupled with SpDamID reveals co-targeting of regulatory sequences by Notch and Runx1. SpDamID represents a sensitive and powerful tool that enables dynamic analysis of combinatorial protein-DNA transactions at a genome-wide level. ACCESSION NUMBER

show abstract

“…In the previous studies, we have focused on mouse cadherin-6 (Cdh6), one of classic cadherin subclasses whose expression demarcates subsets of cortical layers and/or areas (Suzuki et al, 1997;Inoue et al, 1998), and we found out that a 58 kbp long 3 prime territory to mouse Cdh6 gene (Segment X in Inoue et al, 2008a) is required for its mRNA expression along the cortical layer IV-barrel neurons in the primary somatosensory area (S1) at postnatal day 7 (P7; Inoue et al, 2008b;our unpublished data). In the present study, we sought to further narrow down the responsible territory for the expression by systematically deleting genomic regions from the reporter modified BAC clone that can recapitulate Cdh6 expression in S1-barrel layer IV neurons at P7.…”

Section: Cdh6 Gene Expression Along Cortical Layer IV Neurons In the mentioning

confidence: 99%

“…We succeeded in finding out that different genomic territories, located as far as 100-kbp upstream or downstream from the transcription start-site, is required for Cdh6 expression at the defined time and place (Inoue et al, 2008a;Inoue et al, 2008b). Here, we extend the enhancer screening and reveal that a 6-kbp sized 3 prime intergenic region is critical in order to yield Cdh6 expression along the somatosensory barrel, a distinct cytoarchitecture of the mouse cerebral cortex, at around postnatal day 7 (P7).…”

Section: Introductionmentioning

confidence: 99%

Bacterial Artificial Chromosome-Based Experimental Strategies in the Field of Developmental Neuroscience

Terakawa¹,

Inoue²,

Asami³

et al. 2011

Bacterial Artificial Chromosomes

Self Cite

View full text Add to dashboard Cite

Cadherin-6 gene regulatory patterns in the postnatal mouse brain

Cited by 25 publications

References 29 publications

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

Antioxidant Therapies for Wound Healing: A Clinical Guide to Currently Commercially Available Products

SpDamID: Marking DNA Bound by Protein Complexes Identifies Notch-Dimer Responsive Enhancers

Bacterial Artificial Chromosome-Based Experimental Strategies in the Field of Developmental Neuroscience

Contact Info

Product

Resources

About