Cadherin‐mediated adhesion takes control

Abstract

The formation of a centralised apical membrane initiation site (AMIS) is a key event in epithelial cell polarisation. A recent study by Liang et al demonstrates that AMIS localisation relies on cadherinmediated cell adhesion.

Research progress on the regulatory mechanism of integrin‐mediated mechanical stress in cells involved in bone metabolism

“…Unlike integrins, which mediate cell‐to‐ECM adhesion, cadherins mainly mediate cell‐to‐cell adhesion. Cadherins are a class of Ca 2+ −dependent adhesion molecules and are divided into the following subtypes: E‐cadherin, N‐cadherin and P‐cadherin 136 . Cadherins can combine with β‐catenin to form a cadherin‐catenin complex 137 .…”

“…[122][123][124][125] −dependent adhesion molecules and are divided into the following subtypes: E-cadherin, N-cadherin and P-cadherin. 136 Cadherins can combine with β-catenin to form a cadherin-catenin complex. 137 As a sensitive mechanosensor, this complex regulates intracellular signalling pathways by linking the intracellular cytoskeleton, 138…”

CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia

“…In this article, we image, process, and analyze whole Madin-Darby canine kidney (MDCK) 3D epithelial cell cultures. 39 Despite their simplicity, these cysts have previously been used as a suitable model system to study the establishment of cell polarity and cell junctions, 3 , 40 , 41 , 42 , 43 epithelial morphogenesis and physiology, 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 and tumor progression, 52 , 53 , 54 , 55 and for exploring the constraints on epithelial tissue morphogenesis. 56 MDCK cysts have provided valuable insights into the study of more complex systems, helping us to understand self-organization in organoids, embryoids, and the early stages of mammal development.…”

CartoCell, a high-content pipeline for 3D image analysis, unveils cell morphology patterns in epithelia

“…In this article, we image, process, and analyze whole Madin-Darby Canine Kidney (MDCK) 3D epithelial cell cultures. Despite their simplicity, these cysts have previously been used as a suitable model system to study the establishment of cell polarity and cell junctions (Bryant & Mostov, 2008; Dukes et al, 2011; Martín-Belmonte et al, 2008; Vidal-Quadras et al, 2017; Yonemura, 2014), epithelial morphogenesis and physiology (Alfonso-Pérez et al, 2022; Guo et al, 2008; Herranz & Martín-Belmonte, 2022; Imai et al, 2015; O’Brien et al, 2002; Wells et al, 2013; Yu et al, 2007), tumor progression (Fessenden et al, 2018; Sakurai et al, 2012; Schmeichel & Bissell, 2003; L. Yan et al, 2021), and for exploring the constraints on epithelial tissue morphogenesis (Beck et al, 2022). MDCK cysts have provided a lot of useful information to study more complex systems helping to understand the self-organization in organoids, embryoids and the early stages of mammal development (Beck et al, 2022; Carleton et al, 2022; Metzger et al, 2018).…”