Cadmium exposure and DNA damage (genotoxicity): a systematic review and meta-analysis

Nagaraju, Raju; Kalahasthi, Ravibabu; Balachandar, Rakesh; Bagepally, Bhavani Shankara

doi:10.1080/10408444.2023.2173557

Cited by 10 publications

(3 citation statements)

References 75 publications

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“…Furthermore, the identified indicators of early effect are not specific to the exposure to FA, but they can also form following exposure to other toxic and/or carcinogenic substances in workplaces. Several studies demonstrated that DNA damage and other early adverse effects can be determined by the occupational exposure to a large number of inorganic and organic compounds, such as cadmium [68], cytostatic/antineoplastic drugs [69], benzene and other polycyclic aromatic hydrocarbons [70], organochlorides [71], and others.…”

Section: Discussionmentioning

confidence: 99%

Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

Protano,

Antonucci,

De Giorgi

et al. 2024

Sustainability

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The aim of the present review was to identify all the biomarkers used for assessing the internal dose and the related early effects determined by the occupational exposure to formaldehyde. For this purpose, a systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The protocol was registered in PROSPERO (ID: CRD42023416960). An electronic search of Pubmed, Scopus, and Web of Science was performed to collect all the papers concerning the focus of the review and published from the inception of each database until 18 September 2023. Articles were considered eligible if they reported data from observational studies, semi-experimental, and experimental studies on adult workers who were occupationally exposed to formaldehyde, regardless of gender or age. The quality assessment was performed using the adapted Newcastle–Ottawa Quality Assessment Scale. From 1524 articles, 52 were included. Few studies assessed the exposure to formaldehyde in occupational settings through biomarkers, especially by measuring formic acid in urine. The most common approach for evaluating the effects derived from occupational exposure to formaldehyde was the use of the cytogenetic biomarker micronucleus assay in peripheral blood lymphocytes and/or epithelial buccal cells.

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Section: Discussionmentioning

confidence: 99%

Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

Protano,

Antonucci,

De Giorgi

et al. 2024

Sustainability

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“… 211 Cd 2+ can react directly with DNA, such as binding with phosphoric acid and base in DNA, which is very harmful to organism. 212 The release of Cd 2+ ion in the system is an important but not the only factor causing cell damage, and other mechanisms affecting its toxicity need further study.…”

Section: Toxicity Mechanismmentioning

confidence: 99%

A Review of in vivo Toxicity of Quantum Dots in Animal Models

Lin,

Chen

2023

IJN

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Tremendous research efforts have been devoted to nanoparticles for applications in optoelectronics and biomedicine. Over the past decade, quantum dots (QDs) have become one of the fastest growing areas of research in nanotechnology because of outstanding photophysical properties, including narrow and symmetrical emission spectrum, broad fluorescence excitation spectrum, the tenability of the emission wavelength with the particle size and composition, anti-photobleaching ability and stable fluorescence. These characteristics are suitable for optical imaging, drug delivery and other biomedical applications. Research on QDs toxicology has demonstrated QDs affect or damage the biological system to some extent, and this situation is generally caused by the metal ions and some special properties in QDs, which hinders the further application of QDs in the biomedical field. The toxicological mechanism mainly stems from the release of heavy metal ions and generation of reactive oxygen species (ROS). At the same time, the contact reaction with QDs also cause disorders in organelles and changes in gene expression profiles. In this review, we try to present an overview of the toxicity and related toxicity mechanisms of QDs in different target organs. It is believed that the evaluation of toxicity and the synthesis of environmentally friendly QDs are the primary issues to be addressed for future widespread applications. However, considering the many different types and potential modifications, this review on the potential toxicity of QDs is still not clearly elucidated, and further research is needed on this meaningful topic.

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“…For instance, they can interact with various cellular macromolecules, such as DNA, proteins, and membranes. As a result, they induce serious cellular disturbances, including DNA damage [10][11][12], oxidative stress [13][14][15], and proteotoxicity [16,17]. To cope with these challenges, in the course of evolution, cells have developed distinct mechanisms of detoxification and adaptation involving the regulation of specific transporters and enzymes involved in the uptake, sequestration, metabolism, or export of these toxic compounds.…”

Section: Introductionmentioning

confidence: 99%

Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast

Zbieralski,

Staszewski,

Konczak

et al. 2024

IJMS

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In the face of flourishing industrialization and global trade, heavy metal and metalloid contamination of the environment is a growing concern throughout the world. The widespread presence of highly toxic compounds of arsenic, antimony, and cadmium in nature poses a particular threat to human health. Prolonged exposure to these toxins has been associated with severe human diseases, including cancer, diabetes, and neurodegenerative disorders. These toxins are known to induce analogous cellular stresses, such as DNA damage, disturbance of redox homeostasis, and proteotoxicity. To overcome these threats and improve or devise treatment methods, it is crucial to understand the mechanisms of cellular detoxification in metal and metalloid stress. Membrane proteins are key cellular components involved in the uptake, vacuolar/lysosomal sequestration, and efflux of these compounds; thus, deciphering the multilevel regulation of these proteins is of the utmost importance. In this review, we summarize data on the mechanisms of arsenic, antimony, and cadmium detoxification in the context of membrane proteome. We used yeast Saccharomyces cerevisiae as a eukaryotic model to elucidate the complex mechanisms of the production, regulation, and degradation of selected membrane transporters under metal(loid)-induced stress conditions. Additionally, we present data on orthologues membrane proteins involved in metal(loid)-associated diseases in humans.

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Cadmium exposure and DNA damage (genotoxicity): a systematic review and meta-analysis

Cited by 10 publications

References 75 publications

Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

Exposure and Early Effect Biomarkers for Risk Assessment of Occupational Exposure to Formaldehyde: A Systematic Review

A Review of in vivo Toxicity of Quantum Dots in Animal Models

Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast

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