Cadmium Health Risk Assessment and Anthropogenic Sources of Pollution in Mount-Lebanon Springs

Halwani, Dana A.; Jurdi, Mey; Salem, Fatima K. Abu; Jaffa, Miran A.; Amacha, Nabil; Habib, Rima R.; Dhaini, Hassan R.

doi:10.1007/s12403-019-00301-3

Cited by 24 publications

(8 citation statements)

References 37 publications

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“…In the case of Cd, a well characterized environmental pollutant, its use in the manufacturing industry of paints, batteries and plastics and its presence in phosphate fertilizers is causing serious concern regarding its occurrence and effects in the environment (Halwani et al, 2019; Pan et al, 2010). Yet, although Cd is genotoxic, interferes with DNA repair machinery, shows clastogenic effects, provoke DNA strand breakage and exert oxidative stress (Filipič, 2012; Hartwig, 2018; Sherrer et al, 2018), its mutagenesis mechanism is still undefined (Morales et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

Doria

Waldvogel

Pfenninger

2020

Preprint

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Existing mutagenicity tests for metazoans lack the direct observation of enhanced germline mutation rates after exposure to anthropogenic substances, therefore being inefficient. Cadmium (Cd) is a metal described as a mutagen in mammalian cells and listed as a group 1 carcinogenic and mutagenic substance. But Cd mutagenesis mechanism is not yet clear. Therefore, in the present study, we propose a method coupling short-term mutation accumulation (MA) lines with subsequent whole genome sequencing (WGS) and a dedicated data analysis pipeline to investigate if chronic Cd exposure on Chironomus riparius can alter the rate at which de novo point mutations appear. Results show that Cd exposure did not affect the basal germline mutation rate nor the mutational spectrum in C. riparius, thereby arguing that exposed organisms might experience a range of other toxic effects before any mutagenic effect may occur. We show that it is possible to establish a practical and easily implemented pipeline to rapidly detect germ cell mutagens in a metazoan test organism. Furthermore, our data implicate that it is questionable to transfer mutagenicity assessments based on in vitro methods to complex metazoans.

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Section: Discussionmentioning

confidence: 99%

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

Doria

Waldvogel

Pfenninger

2020

Preprint

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“…Cadmium (Cd) has low permissible limits. It is a highly toxic heavy metal and has the potential to cause adverse health effects (Wu et al 2016;Halwani et al 2020). In our study, the average values for cadmium measurements in Acı Lake were, 0.0001 μg/ L at July 2014, 0.0009 μg/ L at October 2014 and 0.0005 μg/ L at January 2015.…”

Section: Discussionmentioning

confidence: 54%

Acı Göl ve Meke Gölü’ nün (Konya / Türkiye) Bazı Su Kalitesi Özellikleri

Aşıkkutlu

Gümüş

Akköz

2021

Journal of Limnology and Freshwater Fisheries Research

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Living beings need water to sustain their lives. Usage, conservation and management of water supplies are therefore extremely important. Researches on the investigation of the water quality properties of aquatic ecosystems are frequently carried out. The purpose of this study is to determine water quality characteristics of Acı Lake and Meke Lake. The lakes are located in Konya Province, Karapınar District and they are important habitats for birds and other species. In this study, some physical and inorganic parameters were examined in

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“…to contain fecal coliforms (mainly Escherichia coli), pesticides, and heavy metals including Arsenic and Cadmium. [75][76][77] Population growth and Syrian refugees, urbanization, economic crisis, and climate change have increased water demands and wastewater generation in Lebanon. 64 Lebanon's water is polluted and poorly conserved, causing chronic water shortages, a lack of safe and improved water resources, and unconventional water sources.…”

Section: Discussionmentioning

confidence: 99%

Lung Cancer and Risk Factors in Lebanon: Epidemiology, Temporal Trends, and Comparison to Countries From Different Regions in the World

et al. 2023

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Background Lung cancer (Lca) is the leading cause of cancer morbidity and mortality worldwide. This study examines the Lca incidence and trends in Lebanon and compares them to regional and global ones. It also discusses Lca risk factors in Lebanon. Methods Lung cancer data from the Lebanese National Cancer Registry for 2005 to 2016 was obtained. The age-standardized incidence rates (ASRw) and age-specific rates per 100 000 population were calculated. Results Lung cancer ranked second for cancer incidence in Lebanon from 2005-2016. Lung cancer ASRw ranged from 25.3 to 37.1 per 100 000 males and 9.8 to 16.7 per 100 000 females. Males 70-74 and females 75+ had the highest incidence. Lung cancer ASRw in males increased significantly at 3.94% per year from 2005 to 2014 ( P > .05), then decreased non-significantly from 2014 to 2016 ( P < .05). Lung cancer ASRw in females increased significantly at 11.98% per year from 2005 to 2009 ( P > .05), then increased non-significantly from 2009 to 2016 ( P < .05). Males' Lca ASRw in Lebanon was lower than the global average in 2008 and became similar in 2012 (34.1 vs 34.2 per 100 000); However, females' Lca ASRw was almost comparable to the global average in 2008 and exceeded it in 2012 (16.5 vs 13.6, respectively, per 100 000). Males’ and Females’ Lca ASRw in Lebanon were among the highest in the Middle East and North Africa (MENA) region but lower than those estimated for North America, China and Japan, and several European countries. The proportion of Lca cases attributed to smoking among Lebanese males and females was estimated at 75.7% and 66.3% for all age groups, respectively. The proportion of Lca cases attributed to air pollution with PM10 and PM2.5 in Lebanon was estimated at 13.5% for all age groups. Conclusion Lung cancer incidence in Lebanon is among the highest in the MENA region. The leading known modifiable risk factors are tobacco smoking and air pollution.

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Cadmium Health Risk Assessment and Anthropogenic Sources of Pollution in Mount-Lebanon Springs

Cited by 24 publications

References 37 publications

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

Measuring mutagenicity in ecotoxicology: A case study of Cd exposure inChironomus riparius

Acı Göl ve Meke Gölü’ nün (Konya / Türkiye) Bazı Su Kalitesi Özellikleri

Lung Cancer and Risk Factors in Lebanon: Epidemiology, Temporal Trends, and Comparison to Countries From Different Regions in the World

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