Cadmium-induced splenic lymphocytes anoikis is not mitigated by activating Nrf2-mediated antioxidative defense response

Guan, Tian-Qi; Qiu, Bai-Hao; Nurmamedov, Hakberdi; Talukder, Milton; Lv, Mei-Wei; Li, Jinlong

doi:10.1016/j.jinorgbio.2022.111882

Cited by 16 publications

(11 citation statements)

References 75 publications

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“…It is known that Cd is a vital contaminant in the environment and can severely damage several organs, including the cerebrum; 24 thus it is important to seek drug candidates or antagonists. 56 A relevant study has shown that RES is a neuroprotective agent that plays a certain role in the treatment of various neurodegenerative diseases, and its neuroprotective potential rests with entry and bioavailability in the cerebrum. Therefore, it is speculated that RES might antagonize Cd-induced cerebrum toxicity.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Zhang

et al. 2023

J Sci Food Agric

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BACKGROUND Cadmium (Cd), known as a vital contaminant in the environment, penetrates the blood–brain barrier and accumulates in the cerebrum. Acute toxicosis of Cd, which leads to lethal cerebral edema, intracellular accumulation and cellular dysfunction, remains to be illuminated with regard to the exact molecular mechanism of cerebral toxicity. Resveratrol (RES), present in the edible portions of numerous plants, is a simply acquirable and correspondingly less toxic natural compound with neuroprotective potential, which provides some theoretical bases for antagonizing Cd‐induced cerebral toxicity. RESULTS This work was executed to research the protective effects of RES against Cd‐induced toxicity in chicken cerebrum. Markedly, these lesions were increased in the Cd group, which also exhibited a thinner cortex, reduced granule cells, vacuolar degeneration, and an enlarged medullary space in the cerebrum. Furthermore, Cd induced CYP450 enzyme metabolism disorders by disrupting the nuclear xenobiotic receptor response (NXRs), enabling the cerebrum to reduce the ability to metabolize exogenous substances, eventually leading to Cd accumulation. Meanwhile, accumulated Cd promoted oxidative damage and synergistically promoted the damage to neurons and glial cells. CONCLUSION RES initiated NXRs (especially for aromatic receptor and pregnancy alkane X receptor), decreasing the expression of CYP450 genes, changing the content of CYP450, maintaining CYP450 enzyme normal activities, and exerting antagonistic action against the Cd‐induced abnormal response of nuclear receptors. These results suggest that the cerebrum toxicity caused by Cd was reduced by pretreatment with RES. © 2023 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Zhang

et al. 2023

J Sci Food Agric

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“…Cadmium (Cd) is an environmental heavy metal that is one of the dangerous materials to food, water, soil, and animals 20 . Cd causes damage to various physiological and biochemical activities of organs or tissue in animals, such as hepatotoxicity, nephrotoxicity, cardiotoxicity, and pulmonotoxi 21–25 . Cd from industrial contaminant can accumulate in the lung to impair resolution, but repeated inflammation causing chronic obstructive pulmonary disease (COPD) 26 .…”

Section: Introductionmentioning

confidence: 99%

“…20 Cd causes damage to various physiological and biochemical activities of organs or tissue in animals, such as hepatotoxicity, nephrotoxicity, cardiotoxicity, and pulmonotoxi. [21][22][23][24][25] Cd from industrial contaminant can accumulate in the lung to impair resolution, but repeated inflammation causing chronic obstructive pulmonary disease (COPD). 26 However, as a consideration of the Cd transformation process in the environmental and biological mediums, more studies focusing on its relatively high exposure dose are limited.…”

Section: Introductionmentioning

confidence: 99%

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Tong

Guo

et al. 2023

Environmental Toxicology

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Cadmium (Cd) is an environmental heavy metal, and its accumulation is harmful to animal and human health. The cytotoxicity of Cd includes oxidative stress, apoptosis, and mitochondrial histopathological changes. Furthermore, polystyrene (PS) is a kind of microplastic piece derived from biotic and abiotic weathering courses, and has toxicity in various aspects. However, the potential mechanism of action of Cd co-treated with PS is still poorly unclear. The objective of this study was to investigate the effects of PS on Cd-induced histopathological injury of mitochondria in the lung of mice. In this study, the results have showed that Cd could induce the activity of oxidative enzymes of the lung cells in mice, increasing the content of partial microelement and the phosphorylation of inflammatory factor NF-κB p65. Cd further destroys the integrity of mitochondria by increasing the expression of apoptotic protein and blocking the autophagy. In addition, PS solely group aggravated the lung damage in mice, especially mitochondrial toxicity, and played a synergistic effect with Cd in lung injury. However, how PS can augment mitochondrial damage and synergism with Cd in lung of mice requiring further exploration. Therefore, PS was able to exacerbate Cd-induced mitochondrial damage to the lung in mice by blocking autophagy, and was associated with the apoptosis.

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“…It is commonly found in metal smelters, battery plants, and agricultural fertilizers, which significantly contribute to air, drinking water, and farmland pollution. Hence, preferential Cd absorption by some edibles, daily diet, and tainted water also constitute a substantial risk factor for Cd poisoning . Recent research has revealed that Cd contamination is ubiquitous, especially in hepatocytes .…”

Section: Introductionmentioning

confidence: 99%

“…Hence, preferential Cd absorption by some edibles, daily diet, and tainted water also constitute a substantial risk factor for Cd poisoning. 2 Recent research has revealed that Cd contamination is ubiquitous, especially in hepatocytes. 3 Once ingested, Cd can have a number of harmful effects on the body, including hepatotoxicity, nephrotoxicity, bone toxicity, and carcinogenicity.…”

Section: Introductionmentioning

confidence: 99%

Nano-Selenium Antagonized Cadmium-Induced Liver Fibrosis in Chicken

Sun

Zhao

et al. 2022

J. Agric. Food Chem.

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Cadmium is a global ecological toxic pollutant; in animals, hepatotoxic fibrosis is caused by bioaccumulation of Cd through food chains. We determined the path of nano-Se antagonism in Cd-induced hepatocyte pyroptosis by targeting the APJ-AMPK-PGC1α pathway, using an in vivo model of hepatotoxicity. All 1-day-old chicks were treated with Cd (140 mg/kg BW/day) and/or nano-Se (0.3 or 0.6 mg/kg BW/day) for 90 days. The result showed that Cd (1.55 ± 0.148) activated NLRP3 inflammasome 49.903% as compared to the Con group (1.034 ± 0.008) to release the inflammasome as a result of hepatocyte pyroptosis (2.824 ± 0.057). Compared with the Con group (1.010 ± 0.021), Kupffer cells were 219.109% more to activate astrocytes through the APJ-AMPK-PGC1α pathway, resulting in 185.149% more hepatic fibrosis. However, the fibrosis degree of the H-Se + Cd group (1.252 ± 0.056) was 56.5278% (p < 0.001) lower than that of the Cd group (2.880 ± 0.124). Therefore, this study established that pyroptotic hepatocytes and Kupffer cells could be targeted for nano-Se antagonizing Cd toxicity, which reveals a potential new approach targeting astrocytes for the treatment of liver fibrosis triggered by Cd pollution.

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Cadmium-induced splenic lymphocytes anoikis is not mitigated by activating Nrf2-mediated antioxidative defense response

Cited by 16 publications

References 75 publications

Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Resveratrol protects against cadmium‐induced cerebrum toxicity through modifications of the cytochrome P450 enzyme system in microsomes

Polystyrene exacerbates cadmium‐induced mitochondrial damage to lung by blocking autophagy in mice

Nano-Selenium Antagonized Cadmium-Induced Liver Fibrosis in Chicken

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