Caenorhabditis elegans as a model for exploring the efficacy of synthesized organoruthenium complexes for aging and Alzheimer's disease a neurodegenerative disorder: A systematic approach

Organoruthenium(II) Complexes Ameliorates Oxidative Stress and Impedes the Age Associated Deterioration in Caenorhabditis elegans through JNK-1/DAF-16 Signalling

“…Inside the nucleus, DAF-16 can either activates or represses the transcription of plethora of genes participated in cellular stress response, metabolism, autophagy, dauer formation, xenobiotic detoxification and protein homeostasis 44 , 45 . Furthermore, in our previous study, we found that organoruthenium(II) complexes promotes the DAF-16 nuclear accumulation and augments the expression downstream effector target SOD-3 in C. elegans 46 . Apart from the longevity promotion, DAF-16 also implicated with the progression of age related neurodegenerative disease including HD.…”

“…The antioxidative activities of ligands, starting precursor and complexes were determined by in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical quenching experiment using UV-Vis spectrophotometer (UV-1800, Shimadzu, Japan) as described in our previous study 46 . The scavenging potential (IC 50 - inhibition concentration) was calculated using the following formula: …”

East Indian sandalwood (Santalum album L.) oil confers neuroprotection and geroprotection inCaenorhabditis elegans viaactivating SKN-1/Nrf2 signaling pathway

“…The toxicity was assessed by the endpoint of the percentage of survived animals with three independent experiments, each performed in triplicates. 35 Reproduction was assessed by counting the eggs and offsprings produced by each worm from treated and untreated groups. Growth of the worms was assessed by body size, about 30 randomly-selected day-5 worms per treatment were subjected to analysis for body length measurement using Optika IsView image analyzing system (Optika, Italy).…”

New organoruthenium metallates containing ferrocenecarboxalidine thiosemicarbazones and their nucleic acid/albumin binding and in vitro cytotoxicity

“…Complexes 1-4 exhibited a band at 281-285 nm corresponding to an intraligand transition (n-π * ) and band at 319-345 nm corresponding to ligand to metal charge transfer transition (LMCT). [26] The molar conductivities for the complexes (10 −3 M) in methanol were measured as 104…”