Caerulomycin A inhibits Th2 cell activity: a possible role in the management of asthma

Abstract

We have recently demonstrated that Caerulomycin A induces regulatory T cells differentiation by suppressing Th1 cells activity. The role of regulatory T cells is well established in suppressing the function of Th2 cells. Th2 cells are known to inflict the induction of the activation of asthma. Consequently, in the present study, we monitored the influence of Caerulomycin A in inhibiting the activity of Th2 cells and its impact in recuperating asthma symptoms. Interestingly, we observed that Caerulomycin A significantly suppressed the differentiation of Th2 cells, as evidenced by downregulation in the GATA-3 expression. Further, decline in the levels of IL-4, IL-5 and IL-13 cytokines and IgE was noted in the animals suffering from asthma. Furthermore, we noticed substantial suppression in the inflammatory response and number of eosinophils in the lungs. In essence, this study signifies an important therapeutic role of Caerulomycin A in asthma.

Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes

“…Stained sections were analyzed under a light microscope (Axio Imager M1; Carl Zeiss, Oberkochen, Germany). The degree of lung inflammation and goblet cell hyperplasia was scored on a subjective scale of 0 to 4 as previously described [18]. Briefly, to score the inflammatory cell infiltration in the intraluminal, alveolar, peribronchial, and perivascular regions, cell counts were performed blind based on five point grading system for the following features: 0: normal, 1: few cells, 2: a ring of inflammatory cells 1 cell layer deep; 3: a ring of inflammatory cells 2-4 cells deep, 4: a ring of inflammatory cells of > 4 cells deep.…”

Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation

“…MQ22, and Streptomyces californicus . Caerulomycin A, possessing 4- O -methyl and 6- E -aldoxime groups, is known to act as an antibiotic [ 15 ], anti-asthma agent [ 20 ], and immunosuppressive agent [ 21 ]. Caerulomycin C, which has 3,4-di- O -methyl and 6- E -aldoxime groups, showed similar antibiotic activity [ 16 ].…”

Antimicrobial activities of novel bipyridine compounds produced by a new strain of Saccharothrix isolated from Saharan soil

“…The broad antifungal activity of caerulomycin A has been extensively reported (Chatterjee et al, 1984, Ambavane et al, 2014). Other studies have suggested the important role of caerulomycin A in the regulation of immune homeostasis (Gurram et al, 2014, Kujur et al, 2015). Product 3 (caerulomycin F) presented the same activity spectrum as the two new cyanogrisides, while product 5 (caerulomycinonitrile) has the lowest activity.…”

“…At the time of writing, 9 cyanogrisides and 13 caerulomycins have been isolated and characterized. These compounds have been shown to have antibacterial, antifungal, antiparasitic and antitumor activities (Funk and Divekar, 1959, Chatterjee et al, 1984, Ambavane et al, 2014, Kujur et al, 2015).…”