Caesarean-Section and Neonatal Gut Microbiome: Short and Long Term Effects and New Targets for Early Prevention

Giannattasio, Antonietta; Guarino, Alfredo

doi:10.1159/000491812

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…This aberrant colonization has been generally linked to absent or limited exposure to maternal microbiota due to shortened labor or cesarean birth [43], exposure to broad-spectrum antibiotics [44], delays in enteral feeding, use of formula feeding [45], and finally to horizontal transmission of bacteria selected in the NICUs’ inhospitable environment. [46]…”

Section: Neonatal Dysbiosis and Consequences For The Premature Infmentioning

confidence: 99%

Dysbiosis and Prematurity: Is There a Role for Probiotics?

et al. 2019

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Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

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Section: Neonatal Dysbiosis and Consequences For The Premature Infmentioning

confidence: 99%

Dysbiosis and Prematurity: Is There a Role for Probiotics?

et al. 2019

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“…Caesarean section (CS) has been associated with increased risk of CIDs of the offspring, possibly as a consequence of increased host susceptibility for CIDs mediated by alterations in the microbial exposure, and a delayed establishment of the gut microbiota that may impair the maturation of the mucosal immune system. 21 In contrast to planned CS (elective CS), acute CS will often be performed after initiation of the labour, where an open birth canal might potentially give access to the vaginal microbial community. Studies have addressed the risk of developing IBD, [22][23][24][25][26][27] DM, [27][28][29][30] CD, [31][32][33] and RA.…”

Section: Introductionmentioning

confidence: 99%

<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Andersen¹,

Möller²,

Jensen³

et al. 2020

CLEP

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Background: Chronic inflammatory diseases in childhood and early adult life share aetiological factors operating from birth and onwards. In this study, we use data from the national Danish health registers to evaluate the risk of developing four common, immune-mediated hospital-diagnosed childhood chronic inflammatory diseases. Methods: A national population-based registry study. Data from the Danish Medical Birth Registry and the Danish National Patient Registry from January 1973 to March 2016 were linked at a personal level to evaluate any potential associations between caesarean section and development of Inflammatory bowel diseases, rheumatoid arthritis, coeliac disease and diabetes mellitus among the offspring. A model adjusted for parental age at birth, decade of birth, gender of child, and parents' chronic inflammatory disease status was used. Results: This register-based national cohort study of 2672708 children with information on delivery mode found an increased risk of diabetes, arthritis, coeliac disease, and inflammatory bowel disease for both girls and boys after caesarean section compared with vaginal delivery. The higher risk was present at least 40 years after delivery. In a subgroup analysis, both acute and elective caesarean section was associated with an increased risk of developing a chronic inflammatory disease. Conclusions: Being born by caesarean section leads to increased host susceptibility for chronic inflammatory diseases that last for decades. This finding should be further addressed in future studies with the aim to support the development of new strategies for prevention, treatment, and maybe even cure.

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“…Cesárea: El parto por cesárea predispone a una ECN avanzada según un análisis retrospectivo de 1428 recién nacidos prematuros en una UCIN de nivel III (p = 0,001) (Ongun & et al, 2020). Esto se justifica ya que, durante una cesárea, los factores ambientales (equipo quirúrgico y departo, el aire, otros bebés y trabajadores de la salud) parecen influir más en el microbioma de los bebés nacidos por cesárea a diferencia de los bebés nacidos por parto vaginal (Giannattasio & Guarino, 2018).…”

Section: A Factores De Riesgo Perinatales Y Del Partounclassified

Enterocolitis Necrosante neonatal: Factores de riesgo y medidas de prevención

Muso Guagchinga,

Philco Toaza

2023

Pentaciencias

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La Enterocolitis Necrosante Neonatal (ECN) es una emergencia gastrointestinal grave, que afecta principalmente a los recién nacidos prematuros, su fisiopatología es multifactorial y la gravedad se puede clasificar mediante el sistema de estadificación de Bell. Se realizó una revisión bibliográfica basada en artículos científicos originales, metaanálisis y revisiones sistemáticas obtenidas de diferentes bases de datos y se analizaron los resultados de 66 artículos científicos. Se determinó que el principal factor de riesgo para ECN es la prematuridad, el mismo que influye en los demás factores de riesgo. Los factores de riesgo se clasificaron en maternos y prenatales, perinatales y del parto y factores de riesgos neonatales tempranos y postnatales. Dentro de las medidas de prevención contra la ECN se hallaron a la alimentación con leche materna, la implementación de un protocolo de alimentación estandarizado, la suplementación con probióticos y la restricción del uso de antibióticos. La prematuridad influye en el desarrollo de ECN por ende es importante que se tomen medidas preventivas para evitar partos prematuros. Por otro lado, la lactancia materna es la estrategia más costo-efectiva contra la ECN por lo que se sugiere un mayor apoyo a la lactancia materna y la instauración de bancos de leche humana.

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Caesarean-Section and Neonatal Gut Microbiome: Short and Long Term Effects and New Targets for Early Prevention

Cited by 4 publications

References 27 publications

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Dysbiosis and Prematurity: Is There a Role for Probiotics?

<p>Caesarean Delivery and Risk of Chronic Inflammatory Diseases (Inflammatory Bowel Disease, Rheumatoid Arthritis, Coeliac Disease, and Diabetes Mellitus): A Population Based Registry Study of 2,699,479 Births in Denmark During 1973–2016</p>

Enterocolitis Necrosante neonatal: Factores de riesgo y medidas de prevención

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