CAF-1 promotes efficient PrimPol recruitment to nascent DNA for single-stranded DNA gap formation
Joshua Straka,
Jude B Khatib,
Lindsey Pale
et al.
Abstract:Suppression of single-stranded DNA (ssDNA) gap accumulation at replication forks has emerged as a potential determinant of chemosensitivity in homologous recombination (HR)-deficient tumors, as ssDNA gaps are transformed into cytotoxic double-stranded DNA breaks. We have previously shown that the histone chaperone CAF-1’s nucleosome deposition function is vital to preventing degradation of stalled replication forks correlating with HR-deficient cells’ response to genotoxic drugs. Here we report that the CAF-1–… Show more
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