Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

Tolba, Mai F.; Azab, Samar S.; Khalifa, Amani E.; Abdel‐Rahman, Sherif Z.; Abdel-Naim, Ashraf B.

doi:10.1002/iub.1189

Cited by 149 publications

(114 citation statements)

References 60 publications

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“…Test sessions were carried out during a 4 week period, with at least 48 hours between sessions as a washout period. The half-lives of the primary bioactives of each of the test extracts were shown to be in the range of 20 minutes to 5.5 hours [28][29][30].…”

Section: Methodsmentioning

confidence: 99%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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Background: Obesity and diabetes are highly prevalent in Western countries. Both of these conditions can be associated with impaired glucose control and hyperglycemia. Studies have identified that antioxidants have the ability to regulate blood glucose levels. However, the effects of specific high-antioxidant food extracts on blood glucose levels have not been well characterized. Thus, this study aimed to measure the effects of selected antioxidant food extracts on postprandial glucose responses in healthy individuals. Methods:Ten healthy individuals were recruited into a randomized, single-blinded study. Participants consumed five different high-antioxidant food extracts (one per session, each >48 hours apart) that were matched for total antioxidant content 10 mins prior to ingestion of 50 g of available carbohydrate from either a glucose load or white bread (with ham) after an overnight fast. Blood glucose levels were measured using capillary sampling every 15 mins for two hours and the incremental area under the glucose curve (IAUC) was also measured. The IAUC values for the test foods were compared to the glucose-only and bread-only controls.Results: Amla berry-, grape seed-rooibos tea-and green tea-extracts as well as propolis tincture were all strong glycemic modulators, significantly decreasing the IAUC by 25-40% compared to the glucose-only or white bread controls (all p < 0.05). Conclusion:Antioxidants are able to modulate postprandial glucose responses in healthy subjects. These results suggest that further research is warranted to determine whether these antioxidant-rich foods are beneficial to people with prediabetes or type 2 diabetes mellitus.

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Section: Methodsmentioning

confidence: 99%

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Chepulis¹,

Al-Aubaidy²,

Page³

2016

FFHD

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“…Caffeic acid phenethyl ester is known to have neuroprotective, hepato-protective, and cardio-protective activities with anti-inflammatory and anti-oxidative effects [11,12,29], and the ILE has become a focus of interest in the treatment of lipophilic drug toxicities [15]. Caffeic acid phenethyl ester and the CAPE+IL have been reported to be effective in attenuating the renal toxicity induced by dichlorvos that is an OP compound [9].…”

Section: Histopathological Evaluationmentioning

confidence: 99%

“…Traditional medicine takes advantage of propolis as a dietary supplement for therapeutic aims. It has neuroprotective, hepatoprotective and cardioprotective activities with anti-inflammatory and anti-oxidative effects [11,12].…”

Section: Introductionmentioning

confidence: 99%

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

Dokuyucu¹,

Bilgili²,

Hanedan³

et al. 2016

Med Pr

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Background: Chlorpyrifos (CPF), insecticide widely used in agriculture, may cause poisonings in the case of humans. As a result, there is a large amount of treatment research underway to focus on the possibility of chlorpyrifos induced poisonings. The aim of this study has been to evaluate the effects of caffeic acid phenethyl ester (CAPE) and intralipid (IL) on hepatotoxicity induced by chlorpyrifos in the case of rats. Material and Methods: The rats in this study were treated with CPF (10 mg/kg body weight (b.w.), orally), CAPE (10 µmol/kg b.w., intraperitoneally), IL (18.6 ml/kg b.w., orally), CPF+CAPE, CPF+IL, and CPF+CAPE+IL. The plasma total oxidant capacity (TOC), total antioxidant capacity (TAC) were measured and the oxidative stress index (OSI) was calculated. Liver histopathology and immunohistochemical staining were performed. Results: Chlorpyrifos statistically significantly decreased the TAC levels in the rats' plasma and increased the apoptosis and the TOC and OSI levels. In the chlorpyrifos induced liver injury, CAPE and CAPE+IL significantly decreased the plasma OSI levels and the apoptosis, and significantly increased the plasma TAC levels. Conclusions: This study revealed that CAPE and CAPE+IL attenuate chlorpyrifos induced liver injuries by decreasing oxidative stress and apoptosis. Med Pr 2016;67(6):743-749

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“…CAPE is known to possess a wide array of pharmacological activities such as antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, neuroprotective, hepatoprotective, cardioprotective and immunostimulant. [16][17][18][19][20][21][22][23] Although numerous preclinical studies demonstrate the effectiveness of CAPE, its therapeutic utility is limited on account of its poor bioavailability which is ascribed to its poor aqueous solubility. 24,25 Most of the documented scientific reports focus on chemical synthesis 26,27,28 and biological evaluation of CAPE or its derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…24,25 Most of the documented scientific reports focus on chemical synthesis 26,27,28 and biological evaluation of CAPE or its derivatives. 29,16 However, a systematic analysis of its crystal structures directed towards improving its physicochemical properties is not known in the literature. A benzene solvate of CAPE is reported, 30 but its structural details were not found in the Cambridge Structural Database (CSD).…”

Section: Introductionmentioning

confidence: 99%

Tracing the Architecture of Caffeic Acid Phenethyl Ester Cocrystals: Studies on Crystal Structure, Solubility, and Bioavailability Implications

Ketkar

Pagire

Goud

et al. 2016

Crystal Growth & Design

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Link to publisher's version: http: //dx.doi.org/ 10.1021/acs.cgd.6b00759 Citation: Ketkar S, Pagire SK, Goud RN et al. (2016) Tracing the architecture of caffeic acid phenethyl ester cocrystals: studies on crystal structure, solubility, and bioavailability implications. Crystal Growth and Design. 16(10): 5710-5716. ABSTRACTCaffeic acid phenethyl ester (CAPE) is a polyphenolic active compound present in popular apiproduct, 'propolis' obtained from beehives. Though it has broad therapeutic capability, the bioavailability of CAPE is limited due to poor solubility. In this study, we report novel cocrystals of CAPE engineered using coformers such as caffeine (CAF), isonicotinamide (INIC), nicotinamide (NIC) with enhanced solubility and bioavailability of CAPE. The cocrystals were prepared by microwave-assisted cocrystallization and characterized using PXRD, DSC and Raman spectroscopy. PXRD and DSC confirm the successful formation and phase purity of CAPE-CAF, CAPE-INIC and CAPE-NIC cocrystals. Raman spectra of CAPE cocrystals complement these results in confirming the formation of novel crystalline phases. CAPE-NIC cocrystal was further subjected to X-ray crystallography to understand its molecular arrangement and hydrogen bonding in the crystal structure. The CAPE-NIC cocrystal structure is found to be stabilized by a rare 1,2-benzenediol-amide heterosynthon. Cocrystallization of CAPE with NIC improved its aqueous solubility and pharmacokinetic profile thereby demonstrating 2.76 folds escalation in bioavailability.

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Caffeic acid phenethyl ester, a promising component of propolis with a plethora of biological activities: A review on its anti‐inflammatory, neuroprotective, hepatoprotective, and cardioprotective effects

Cited by 149 publications

References 60 publications

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts

Attenuating effects of caffeic acid phenethyl ester with intralipid on hepatotoxicity of chlorpyrifos in the case of rats

Tracing the Architecture of Caffeic Acid Phenethyl Ester Cocrystals: Studies on Crystal Structure, Solubility, and Bioavailability Implications

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