Caffeic acid phenethyl ester ameliorates cerebral infarction in rats subjected to focal cerebral ischemia

The Effects of Caffeic Acid Phenethyl Ester on Inflammatory Cytokines after Acute Spinal Cord Injury

“…[17] The protective effects of CAPE have been practiced in various studies dealing with cerebral ischemia-reperfusion injury, spinal cord ischemia-reperfusion injury, Parkinson's disease, hypoxic ischemic brain damage in newborns, multiple sclerosis, convulsions, brain tumors, toxic effects of therapeutic agent in anticancer therapies, and hepatic encephalopathy. [3][4][5][6][7][8][9][10][11] There are only five studies in the literature evaluating the effects of CAPE in the spinal cord. [5,8,11,18,19] Two of these studies have been performed to evaluate the protective effects of CAPE against experimental allergic encephalomyelitisinduced oxidative stress, and in methotrexate administered rats.…”

“…Protective effects of CAPE in the nervous system have been reported in cerebral ischemic reperfusion injury, ischemic damage of the spinal cord, Parkinson's disease, convulsions, multiple sclerosis, brain tumors, hepatic encephalopathy, and against toxic effects of therapeutic agents in anticancer therapy. [3][4][5][6][7][8][9][10][11] Moreover, studies evaluating its protective effect in spinal cord ischemia-reperfusion models and hemi-transection model have been reported; however, there is no study investigating the acute effects of CAPE in traumatic acute spinal cord injury in clip compression model. Therefore, this study was conducted to evaluate the early anti-cytotoxic effects of CAPE in acute spinal cord injury.…”

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

“…Ester derivatives of caffeic acid also exhibit various biological activities [20]. For example, caffeic acid phenylethyl ester (CAPE), an antioxidant component of propolis, protects against glutamate-induced neurotoxicity [21] and cerebral ischemia [22]. Although DC was previously identified in the root of Sohora subprostrata [23], its biological activity was never demonstrated.…”

Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

“…As a potent antioxidant [4,5] , caffeic acid exerts anti-inflammatory effects [6] . One of caffeic acid derivatives, caffeic acid phenethyl ester (CAPE), suppressed cerebral lipid peroxidation [7] and reduced brain infarct [8] after cerebral ischemia in rats. In contrast, caffeic acid is an inhibitor of 5-lipoxygenase (5-LOX) [9,10] and can inhibit the biosynthesis of pro-inflammatory leukotrienes.…”