Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

Akyol, Sümeyya; Ugurcu, Veli; Altuntaş, Aynur; Hasgül, Rukiye; Çakmak, Özlem; Akyol, Ömer

doi:10.1155/2014/561971

Cited by 44 publications

(29 citation statements)

References 100 publications

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“…The increase in the serum uric acid levels suggests the failure to excrete diatrizoate by the kidneys. Diatrizoate exposure results in excess production of oxygen free radicals and reduction of antioxidant enzyme activity in the rat kidney (14). The generation of free radicals constitutes one of the underlying mechanisms for intoxication (15).…”

Section: Discussionmentioning

confidence: 99%

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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C ontrast agents are often used in diagnostic imaging or interventional procedures in clinical radiology or nuclear medicine for the purpose of providing contrast enhancement in images. Additional contrast improves the accuracy of detecting pathologic abnormalities in the underlying biological system or the outcome of the intervention. Some of the contrast agents, however, expose the patient to toxic side effects. Diatrizoate is one of those radiocontrast agents used for imaging kidney and its related structures. It has a high-osmolality and contains iodine for absorption of X-rays and hence for producing localized hyperintensities in computed tomography images. In patients with kidney dysfunction, as measured by serum creatinine clearance level of less than 60 mL/min, diatrizoate may lead to kidney failure (1). This effect is called contrast-induced nephropathy (CIN) and constitutes one of the most common causes of hospital-acquired renal failures in clinical practice. Therefore, it is important to develop preventive and/or protective strategies for safeguarding the kidney to be exposed to diatrizoate.Diatrizoate induces kidney damage through a combination of renal ischemia and direct toxic effect on renal tubular cells (2). The mechanism of pathogenesis includes factors such as impaired nitric oxide production, blockade of vasodilation and generation of reactive oxygen species, all promoting oxidative stress. For preventing kidney from acquiring CIN, past attempts were focused on interventions against toxicity and oxidative stress. In this regard, pharmaceuticals N-acetylcystein (NAC) and calpain inhibitor-1 were investigated and determined to be effective (3). As alternative to such man-made pharmaceuticals, natural compounds found in folk medicine have also gained popularity as viable options in health care. The natural product propolis has been explored on various fronts and its therapeutic

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Section: Discussionmentioning

confidence: 99%

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

Baykara

Silici

Özçelik³

et al. 2015

Diagn Interv Radiol

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“…Caffeic acid phenethyl ester atau juga dikenal dengan nama Phenethyl caffeate; CAPE atau Capeee merupakan salah satu senyawa aktif dalam propolis yang banyak diteliti dalam dunia pengobatan karena kemampuan antioksidan (Akyol et al, 2014;Ozkan et al, 2014), anti kanker (Ulasli et al, 2013;Chiang et al, 2014;Tseng et al, 2014), juga sebagai imunomodulator (Ansorge, Reinhold dan Lendeckel, 2003). CAPE memiliki rumus kimia C 17 H 16 O 4 , berat molekul 284.30654 g/mol, dan dapat larut dalam air (PubChem, NCBI).…”

Section: Cape (Caffeic Acid Phenethyl Ester)unclassified

PREDIKSI INTERAKSI MOLEKUER CAPE DENGAN IL-2, CD25, IL-10, CTLA-4, IDO, TGFβ, and CCL2 DENGAN SOFTWARE DOCKING MOLEKULER

Kusnul

2019

SAINTEKBU

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The use of herbal medicine as a nutritious ingredient to treat various diseases is still mostly done traditionally based on hereditary information. The development of technology supports the exploration of natural materials as a nutritious material with various scientific evidences. The development of computational and bioinfrmatic technology simulates interactions between various active compounds and target molecules virtually commonly known as molecular docking, a virtual screening based on structure used to predict the interaction of three-dimensional structures of small molecules (compounds) with the target molecular structure. Propolis is a substance produced by bees from resins collected from plants and combined with wax and secretions from bee salivary glands which are rich in various enzymes. In the world of medicine, propolis has been used since time immemorial and until now it has been known that propolis can be a natural medicine with anti-bacterial, anti-tumor, antioxidant and immunomodulatory abilities. Molecular docking between one of the active compounds in propolis, namely caffeic acid phenethyl ester (CAPE) with various target molecules such as IL-2, CD25, IL10, TGFβ, CTLA-4, CCL21, and IDO using the DockingServer software provides information that CAPE has inhibitory activity against IL-2, CD25, IL-10, CTLA-4, IDO, TGFβ, and CCL2 so that it has the potential to be further developed as a candidate for immunomodulatory therapy.

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“…The well-known side effects of cisplatin are nephrotoxicity, neurotoxicity, ototoxicity, electrolyte disturbances, nausea and vomiting, myelotoxicity, and hemolytic anemia. Herein, nephrotoxicity is the most common adverse effect and it is a major issue [24]. High concentrations of cisplatin and its toxic metabolites related to the risk of nephrotoxicity, therefore cisplatin has been used limitedly.…”

Section: Effect Of Fbg In Body and Kidney Weights And Serum Parametersmentioning

confidence: 99%

Renoprotective Effects of Fermented Black Ginseng through Ameliorating Oxidative Stress Associated with Cisplatin-Induced Acute Nephrotoxicity in Mice

Roh¹,

Kwon²,

Seo³

2018

J Nutr Food Sci

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We aimed to evaluate the renal protective capacity of Fermented Black Ginseng (FBG) and its mechanism to reduce the cisplatin-induced nephrotoxicity. Nephrotoxicity was induced by a single intraperitoneal injection of cisplatin (20 mg/kg) and treated with white ginseng (WB) and FBG (200 mg/kg/day, orally) for 4 days before cisplatin treatment. Biochemical results showed that WG and FBG pretreatment significantly reduced the increase of blood urea nitrogen (BUN) and creatinine, and histopathological changes were meaningfully ameliorated. Cisplatin increased the production of reactive oxygen species (ROS) and depletion of Glutathione (GSH) in serum and kidney, whereas, WG or FBG administration markedly down-regulated. Moreover, the expression of nuclear factor-kappaB (NF-κB), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), and interleukin (IL)-6 was markedly suppressed by both WB and FBG. However, FBG pretreatment was more effective than those of WG in COX-2, iNOS, and IL-6 levels. Moreover, FBG treated mice significantly up-regulated the antioxidative enzymes. In HPLC analysis, the increasing ginsenoside contents that include Rg1, Re, Rb1, Rc, Rb3, Rd, Rg3, Rk1, and Rg5 by heat-processing were greater about 5.7 fold when fermentation additionally. Taken together, FBG may be a worthful candidate for the prevention of nephrotoxicity in patients receiving cisplatin.

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Caffeic Acid Phenethyl Ester as a Protective Agent against Nephrotoxicity and/or Oxidative Kidney Damage: A Detailed Systematic Review

Cited by 44 publications

References 100 publications

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

In vivo nephroprotective efficacy of propolis against contrast-induced nephropathy

PREDIKSI INTERAKSI MOLEKUER CAPE DENGAN IL-2, CD25, IL-10, CTLA-4, IDO, TGFβ, and CCL2 DENGAN SOFTWARE DOCKING MOLEKULER

Renoprotective Effects of Fermented Black Ginseng through Ameliorating Oxidative Stress Associated with Cisplatin-Induced Acute Nephrotoxicity in Mice

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