Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Neamatallah, Thikryat

doi:10.1007/s00210-023-02730-z

Cited by 4 publications

(1 citation statement)

References 71 publications

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“…In a comprehensive study of patients diagnosed with gastric ulcers, it was determined that a noteworthy 25% of these cases were attributed to drug-induced ulcers. Notably, NSAIDs, often prescribed for the management of conditions such as arthritis, cardiovascular diseases, colorectal cancer, and Alzheimer's disease prevention, were the predominant agents responsible for ulcer development, with indomethacin emerging as a prominent example [6][7][8][9]. Indomethacin inhibits the activity of cyclooxygenase (COX) by suppressing the synthesis of prostaglandin.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Effect of Deep-Sea Water on the Therapeutic Potential of the Anti-Inflammatory Response in an Indomethacin-Induced Gastric Ulcer Rat Model

Park,

Im,

Kim

2023

IJMS

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Gastric ulcers are often exacerbated by factors such as nonsteroidal anti-inflammatory drugs (NSAIDs) and inflammation, and they have a substantial impact on a significant portion of the population. Notably, indomethacin is recognized as a prominent contributor to ulcers. This study investigated this potential method, with normalization to the anti-inflammatory and antiulcer properties of deep-sea water (DSW)-derived mineral water, using an indomethacin-induced gastric ulcer model in rats. The study involved four groups (n = 6 rats/group): normal control group (CON), indomethacin-only group (IND), indomethacin with trace mineral water group (TM), and indomethacin with high magnesium low sodium water group (HMLS). For three weeks, the CON and IND groups consumed tap water, while the TM and HMLS groups had access to mineral water. Gastric ulcers were induced on the final day using indomethacin, for all groups except the CON group. The results demonstrated that HMLS intake significantly improved gastric mucosal damage, preserved mucin stability, and increased gastric thickness, indicating its potential to prevent and alleviate indomethacin-induced gastric ulcers. Furthermore, HMLS consumption led to the upregulation of key genes associated with inflammation and a reduction in inflammatory cytokines. These findings suggest that DSW-derived mineral water, and particularly its high Mg2+ content, may offer promising health benefits including anti-inflammatory and anti-ulcer properties.

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Section: Introductionmentioning

confidence: 99%

Exploring the Effect of Deep-Sea Water on the Therapeutic Potential of the Anti-Inflammatory Response in an Indomethacin-Induced Gastric Ulcer Rat Model

Park,

Im,

Kim

2023

IJMS

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Apigenin attenuates indomethacin-induced gastric ulcer in rats: emphasis on antioxidant, anti-inflammatory, anti-apoptotic, and TGF-β1 enhancing activities

Alamri

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis

Nasrullah,

Neamtalllah,

Alshibani

et al. 2024

Clin Exp Pharma Physio

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BackgroundColistin (Cst) is one of the antimicrobial peptides and is reserved for use against multi‐drug‐resistant Gram‐negative bacteria. However, the clinical value of Cst is limited by its nephrotoxic adverse effects. Caffeic acid phenethyl ester (CAPE) is a honeybee propolis flavonoid recognised for its diverse pharmacological potential. It has demonstrated d antioxidant and anti‐inflammatory properties, as well as protective effects against chemically induced toxicity in variuos biological systems. This study aimed to investigate the impact of CAPE on nephrotoxicity induced in rats by Cst.MethodsAnimals were randomly divided into five groups. Group 1 served as control, group 2 received CAPE (10 mg/kg) orally, group 3 received Cst IP, group 4 received Cst + CAPE (5 mg/kg) and group 5 received Cst + CAPE (10 mg/kg). All treatments were given daily for 10 consecutive days.ResultsCAPE notably attenuated Cst‐inducednephrotoxicity as shown by reducing urea serum levels, creatinine, cystatin C, urinary protein contents and urinary N‐acetyl‐β‐D‐glucosaminidase (NAG). This was confirmed by histological investigations that indicated amelioration of histopathological changes in the kidney architecture as well as the deposition of collagen in renal tissues. CAPE exhibited antioxidant effects supported by the prevention of rise in Cst‐induced lipid peroxidation and depletion of superoxide dismutase and catalase enzymatic activities. In addition, CAPE inhibited the expression of the inflammatory markers including tumour necrosis factor‐α, nuclear factor kappa B and interleukin‐6. These actions were associated with modulation of messenger ribonucleic acid (mRNA) expression of Bax and Bcl‐2 in favour of anti‐apoptosis. CAPE inhibited Cst‐induced rise in forkhead box O1 (FOXO1) expression and downregulation of nuclear factor erythroid 2–related factor 2 (Nrf2) and Sirtuin 1 (Sirt1) immune‐expression.ConclusionCAPE protects against nephrotoxicity induced by Cst in ratsprimarily through its antioxidant, antiinflammatory and antiapoptotic activities. These pritective effects are mediated via modulation of FOXO1/Nrf2/Sirt1 axis.

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Caffeic acid phenethyl ester attenuates indomethacin-induced gastric ulcer in rats

Cited by 4 publications

References 71 publications

Exploring the Effect of Deep-Sea Water on the Therapeutic Potential of the Anti-Inflammatory Response in an Indomethacin-Induced Gastric Ulcer Rat Model

Exploring the Effect of Deep-Sea Water on the Therapeutic Potential of the Anti-Inflammatory Response in an Indomethacin-Induced Gastric Ulcer Rat Model

Apigenin attenuates indomethacin-induced gastric ulcer in rats: emphasis on antioxidant, anti-inflammatory, anti-apoptotic, and TGF-β1 enhancing activities

Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis

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