Caffeic acid phenethyl ester changes the indices of oxidative stress in serum of rats with renal ischaemia–reperfusion injury

Abstract

Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischaemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant properties. To investigate whether treatment with either CAPE or alpha-tocopherol modifies the levels of the endogenous indices of oxidant stress, we examined their effects on an in vivo model of renal ischaemia-reperfusion injury in rats. CAPE at 10 micromol kg(-1) or alpha-tocopherol at 10 mg kg(-1) was administered intraperitoneally before reperfusion. Acute administration of both CAPE and alpha-tocopherol altered the indices of oxidative stress differently in renal ischaemia-reperfusion injury.

Levosimendan attenuates ischemia/reperfusion injury of the heart better than ischemic preconditioning during moderate hypothermia

“…Thus, it is able to serve as a reliable marker of oxidative stress (OS). [20] In this study, the MDA levels were clearly decreased in group 6 compared with groups 4 and 5, suggesting that levosimendan alone is effective in the prevention of lipid peroxidation. However, better results occur when it is used in combination with hypothermia.…”

Prevention of renal ischemia/reperfusion‐induced injury in rats by leflunomide

“…After reperfusion and reoxygenation, the imbalance between restoration of oxygen supply and mitochondrial respiratory function results in the massive generation of superoxide anion in mitochondria. 49,50 Under these conditions, the defensive system, which is known as antioxidant or antioxidant enzymes, cannot prevent the escape of ROS especially in mitochondria, and their effects on other intracellular sites. This cascade of events is known as reperfusion injury.…”

“…This cascade of events is known as reperfusion injury. 50 Nitric oxide is recognized as an important mediator of physiological and pathological processes of renal I/R injury. Inducible nitric oxide synthase (iNOS) is expressed in several segments of the renal tubule as well as in the glomerulus and interlobar and arcuate arteries of the normal rat kidney.…”

Protective role of caffeic acid phenethyl ester on serum cholinesterase inhibition by acute exposure to diazinon in rats

“…The second group of rats (Group II, n = 10) was orally given a sublethal dose of 200 mg/kg body weight (bw) of diazinon (12) in corn oil, which was prepared by dissolving a required amount of Basudin in a solution of 60 mg/mL diazinon in corn oil. The third group of rats (Group III, n = 10) were intraperitoneally (ip) given 2.84 mg (10 µmol)/kg bw of CAPE 1 day prior to administration of 200 mg/kg bw of diazinon, dissolved in corn-oil and orally applied via orogastric tube (13). The fourth group of rats (Group IV, n = 10) were ip injected with 2.84 mg (10 µmol)/kg bw of CAPE 30 min administration of 200 mg/kg bw of diazinon, dissolved in corn oil and administered via orogastric tube.…”