Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats

Albukhari, Ashwag; Gashlan, Hana M.; El-Beshbishy, Hesham A.; Nagy, Ayman A.; Abdel-Naim, Ashraf B.

doi:10.1016/j.fct.2009.04.021

Cited by 64 publications

(63 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the current study, treatment of rats with TAM resulted in a threefold increase in TNF-a level. In accordance with our results, it was reported that TAM administration resulted in a significant increase in TNF-a levels in rats (Albukhari et al, 2009;El-Beshbishy et al, 2010). Pretreatment with allicin significantly inhibited the rise in the TNF-a levels.…”

Section: Discussionsupporting

confidence: 82%

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Suddеk

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Tamoxifen (TAM) is widely used for treatment of hormone-dependent breast cancer; however, it may be accompanied with hepatic injury. Allicin is the most abundant thiosulfinate molecule from garlic with the potential to provide beneficial effects on various diseases. Objective: To elucidate the effect of commercially available allicin on both antitumor activity and liver injury of TAM. Materials and methods: The cytotoxicity of TAM and/or allicin was evaluated in vitro using cultured Ehrlich ascites carcinoma (EAC) cells and in vivo against murine tumor (solid) model of EAC. TAM induced liver injury in rats by intraperitoneally (i.p.) injection at a dose of 45 mg/kg, for 7 successive days.Results: TAM at a dose of 3 mM (IC 50 ) significantly decreased percent survival of EAC to 52%. TAM combination with allicin (5 or 10 mM) showed a significant cytotoxic effect compared with the TAM-treated group as manifested by a decrease in percent survival of EAC to 35% and 29%, respectively. Allicin (10 mg/kg, orally) enhanced the efficacy of TAM (1 mg/kg, i.p.) in mice as manifested by a significant increase in solid tumor growth inhibition by 82% compared with 70% in the TAM group. In rats, TAM intoxication resulted in a significant decline in SOD, GSH, and total protein with significant elevation in TBARS, ALT and AST, ALP, LDH, total bilirubin, gGT, and TNF-a levels. These changes are abrogated by allicin treatment. Discussion and conclusion: The results suggest the beneficial role of allicin as an adjuvant to TAM in cancer treatment by alleviating liver injury.

show abstract

Section: Discussionsupporting

confidence: 82%

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Suddеk

2014

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…While, JA extract treatment in the combination group significantly decreased the TAM-induced elevation in TNF-α level by 42.86% ( Figure 3D). Our results showed that treatment of rats with TAM significantly elevated hepatic lipid peroxidation expressed as TBARS which was supported by Albukhari et al findings [28].…”

Section: Effec On Tnfsupporting

confidence: 81%

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

Jamie¹,

Alshami²,

Maliabari³

et al. 2017

Med Aromat Plants

View full text Add to dashboard Cite

Objective: Leaves methanol extract of Jacaranda acutifolia Humb. and Bonpl. (JA) family Bignoniaceae was subjected to phytochemical investigation as well as antioxidant, hepatoprotective, cytotoxic and antihyperglycemic activities evaluation.Key findings: Eight compounds were identified: luteolin-7-O-β-D-glucuronide, luteolin-7-O-β-D-glucoside, aesculetin, luteolin, verbascoside, luteolin-7-O-β-D-glucuronide methyl ester, apigenin-7-O-β-D-glucuronide methyl ester and apigenin. JA revealed a potent antioxidant activity in vitro superior to vitamin E (DPPH assay; EC 50 of 0.43 mg/mL). A potential cytotoxic activity was produced against hepatocellular (HepG2) and cervical (HeLa) carcinoma cells with IC 50 of 6.05 and 16.7 µg, respectively. Treatment with JA extract inhibited the rise in alanine aminotransferase and aspartate aminotransferase by 33.6% and 36.8% respectively, reduced thiobarbituric acid by 35.7% and decreased the tamoxifen-induced elevation in tumor necrosis factor alpha (TNF-α) level by 42.86%. JA extract elicited a significant decrease in fasting blood glucose by -59.26%. Conclusions:Jacaranda acutifolia could be a natural source for antioxidant, hepatoprotective supplements and could provide a basis for a potential cytotoxic agent. The compounds isolated are responsible at least in part for the observed effects.

show abstract

“…It was previously shown the presence of lipoperoxidation in the pathogenesis of TAM-induced liver toxicity (Albukhari et al, 2009). In addition, protein carbonylation is one of the reactions set into motion as a consequence of the formation of oxygen radicals in cells and tissues (Grattagliano et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…With respect to antioxidant defense, it has been described that TAM alters the endogenous antioxidant glutathione (Albukhari et al, 2009). We have found that α-tocopherol a major exogenous antioxidant that acts as a "scavenger" capturing the reactive oxygenic species, was also decreased in the liver and at plasmatic level after TAM treatment, probably as a consequence of its consumption in the situation of enhanced oxidative stres.…”

Section: Discussionmentioning

confidence: 99%

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Codoñer‐Franch

Betoret

López-Jaén

et al. 2013

International Journal of Food Sciences and Nutrition

View full text Add to dashboard Cite

Codoñer Franch, P.; Betoret Valls, ME.; López Jaén, AB.; Betoret Valls, N.; Fito Maupoey, P.; Valls Bellés, MV. (2013). Dried apple enriched with mandarin juice counteracts tamoxifen induced oxidative stress in rats. International Journal of Food Sciences and Nutrition. 64(7): 815-821. doi:10.3109/09637486.2013.798267. Dried apple enriched with mandarin juice by vacuum impregnation counteracts the liver oxidative effect of tamoxifen in rats. AbstractWe have investigated the effects of a product made of apple dehydrated enriched by vacuum impregnation of mandarin juice in decreasing oxidative stress biomarkers in rat induced liver injury by tamoxifen. A experimental design was undertaken in six groups of animals. One group fed a standard diet. Two groups were supplemented with 0.745 g/d of apples snacks/day either impregnated or not with mandarin juice during 28 days. Three groups of rats were treated with tamoxifen 1.54 mg/kg/day during 21 days; of these, one group was supplemented with the apple snacks and the other with the apple snacks impregnated with mandarin juice. Plasma aminotransferases were determined as index of hepatocellular damage and interleukin-6 as measure of inflammation. Plasma and liver carbonyl groups, indicative of protein oxidation, and α-tocopherol as evaluation of antioxidant defense were measured. The modified base 8-hydroxydexyguanosine as indicative of DNA damage was determined in liver. Tamoxifen induced an increase in aminotranferases and both plasma and liver markers of oxidative stress and DNA damage that decrease significantly after apple snack consumption; in most of cases they even reach normal values as those achieved previous to induce the injury with tamoxifen. The effect of the mandarin juice incorporated to the structure of apple mainly accounts for increasing levels of α-tocopherol in plasma and liver. The present study shown the potential protective action of the products made of dehydrated apple either impregnated or not with mandarin juice by vacuum impregnation for counteracting the chemically induced liver injury in rats.

show abstract

Caffeic acid phenethyl ester protects against tamoxifen-induced hepatotoxicity in rats

Cited by 64 publications

References 56 publications

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Allicin enhances chemotherapeutic response and ameliorates tamoxifen-induced liver injury in experimental animals

Hepatoprotective, Antihyperglycemic and Cytotoxic Activities of Jacaranda acutifolia Leaf Extract

Dried apple enriched with mandarin juice counteracts tamoxifen-induced oxidative stress in rats

Contact Info

Product

Resources

About